Opioid

Из Википедије, слободне енциклопедије

Opioid je hemijsko jedinjenje koje se vezuje za opioidne receptore, koji se nalaze prvenstveno u centralnom nervnom sistemu i gastrointestinalnom traktu. Ovi receptori u tim organima posreduju blagotvorne kao i sporedne efekte opioida.[1][2]

[Analgetik|Analgetski]] efekti opioida dolaze os umanjenog percepcije bola, umanjene reakcije na bol kao i povećane tolerancije bola. Nepoželjni efekti opioida su sedacija, respiratorna depresija, i konstipacija. Opioidi mogu da uzrokuju umanjenje kašlja. Fizička zavisnost može da se razvije tokom njihove administracije, koja dovodi do sindroma povlačenja kod naglog prekida upotrebe. Opioidi mogu da proizvedu osećanje euforije.


Vidi još[уреди]

Literatura[уреди]

  1. ^ Chevlen E (February 2003). „Opioids: a review“. Curr Pain Headache Rep 7 (1): 15–23. PMID 12525266. 
  2. ^ Pasternak GW (January 2010). „Molecular insights into mu opioid pharmacology: From the clinic to the bench“. Clin J Pain 26 Suppl 10: S3–9. DOI:10.1097/AJP.0b013e3181c49d2e. PMID 20026962. 

Dodatna literatura[уреди]

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