A-349,821

Из Википедије, слободне енциклопедије
A-349,821
(IUPAC) ime
(4'-[3-(2R,5R-dimetilpirolidin-1-il)propoksi]bifenil-4-il)morfolin-4-ilmetanon
Klinički podaci
Identifikatori
CAS broj 372513-99-0
ATC kod nije dodeljen
PubChem[1][2] 9954017
ChemSpider[3] 8129627
ChEMBL[4] CHEMBL179702 YesY
Hemijski podaci
Formula C26H34N2O3 
Mol. masa 422,558
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

A-349,821 je potentan i selektivan antagonist histaminskog H3 receptora[5] (a verovatno i inverzni agonist).[6] Pokazano je da ima nootropno dejstvo u životinjskim studijama.[7] Ovo jedinjenje se koristi u laboratorijskim istraživanjima.

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining“. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ^ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. ^ Faghih, R; Dwight, W; Pan, JB; Fox, GB; Krueger, KM; Esbenshade, TA; McVey, JM; Marsh, K et al. (2003). „Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists“. Bioorganic & Medicinal Chemistry Letters 13 (7): 1325–8. DOI:10.1016/S0960-894X(03)00118-5. PMID 12657274. 
  6. ^ Witte, DG; Yao, BB; Miller, TR; Carr, TL; Cassar, S; Sharma, R; Faghih, R; Surber, BW et al. (2006). „Detection of multiple H3 receptor affinity states utilizing 3HA-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand“. British Journal of Pharmacology 148 (5): 657–70. DOI:10.1038/sj.bjp.0706752. PMC 1751875. PMID 16715122. 
  7. ^ Esbenshade, TA; Fox, GB; Krueger, KM; Baranowski, JL; Miller, TR; Kang, CH; Denny, LI; Witte, DG et al. (2004). „Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist“. Biochemical pharmacology 68 (5): 933–45. DOI:10.1016/j.bcp.2004.05.048. PMID 15294456. 

Vidi još[уреди]