Mirtazapin

Из Википедије, слободне енциклопедије
Mirtazapin
(IUPAC) ime
(±)-2-metil-1,2,3,4,10,14b-heksahidropirazino[2,1-a]pirido[2,3-c][2]benzazepin
Klinički podaci
Robne marke Remeron, Avanza, Zispin
AHFS/Drugs.com Monografija
MedlinePlus a697009
Identifikatori
CAS broj 61337-67-5
ATC kod N06AX11
PubChem[1][2] 4205
DrugBank DB00370
ChemSpider[3] 4060
UNII A051Q2099Q YesY
KEGG[4] D00563 YesY
ChEBI CHEBI:6950 YesY
ChEMBL[5] CHEMBL654 YesY
Hemijski podaci
Formula C17H19N3 
Mol. masa 265,35 g/mol
SMILES eMolekuli & PubHem
Sinonimi 6-Azamianserin, Org 3770
Fizički podaci
Gustina 1,22 g/cm³
Tačka topljenja 114–116 °C (237–241 °F)
Tačka ključanja 432 °C (810 °F)
Rastvorljivost u voda Rastvoran u metanolu i hloroformu mg/mL (20 °C)
Farmakokinetički podaci
Bioraspoloživost 50%[6]
Vezivanje za proteine plazme 85%[6]
Metabolizam Hepatički (CYP1A2, CYP2D6, i CYP3A4)[7][6]
Poluvreme eliminacije 20–40 sata[6]
Izlučivanje Urin (75%)[6]
Izmet (15%)[6]
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Rx-only
Način primene Oralno

Mirtazapin (Remeron, Avanza, Zispin) je noradrenergički i specifični serotonergički antidepresiv (NaSSA) koji je razvila kompanija Organon International u Sjedinjenim Državama 1990. godine. On se prvenstveno koristi za lečenje depresije. On isto takao nalazi primenu kao anksiolitik, hipnotik, antiemetik i stimulant apetita. On je strukturno sličan sa mianserinom, i klasifikuje se kao tetraciklični antidepresant (TeCA).

Medicinska upotreba[уреди]

Mirtazapin se prvenstveno koristi za tretiranje kliničke depresije i drugih poremećaja raspoloženja.[8][9]

On isto tako može da bude koristan u tretiranju sledećih oboljenja, mada nije odobren za te primene:

Reference[уреди]

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  15. ^ Carli V, Sarchiapone M, Camardese G, Romano L, DeRisio S (July 2002). „Mirtazapine in the treatment of panic disorder“. Arch. Gen. Psychiatry 59 (7): 661–2. DOI:10.1001/archpsyc.59.7.661. PMID 12090820. 
  16. ^ Hrdlicka M, Beranova I, Zamecnikova R, Urbanek T (April 2008). „Mirtazapine in the treatment of adolescent anorexia nervosa. Case-control study“. European Child & Adolescent Psychiatry 17 (3): 187–9. DOI:10.1007/s00787-007-0670-8. PMID 18357426. 
  17. ^ Hartmann PM (January 1999). „Mirtazapine: a newer antidepressant“. Am Fam Physician 59 (1): 159–61. PMID 9917581. 
  18. ^ Jindal RD (2009). „Insomnia in patients with depression: some pathophysiological and treatment considerations“. CNS Drugs 23 (4): 309–29. PMID 19374460. 
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  21. ^ Kast RE, Foley KF (July 2007). „Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects“. Eur J Cancer Care (Engl) 16 (4): 351–4. DOI:10.1111/j.1365-2354.2006.00760.x. PMID 17587360. 
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Literatura[уреди]

  • Stimmel GL, Dopheide JA, Stahl SM (1997). „Mirtazapine: an antidepressant with noradrenergic and specific serotonergic effects“. Pharmacotherapy 17 (1): 10–21. PMID 9017762. 
  • Anttila SA, Leinonen EV (2001). „A review of the pharmacological and clinical profile of mirtazapine“. CNS Drug Rev 7 (3): 249–64. DOI:10.1111/j.1527-3458.2001.tb00198.x. PMID 11607047. 

Spoljašnje veze[уреди]