Klobenpropit

Из Википедије, слободне енциклопедије
Klobenpropit
(IUPAC) ime
N'-[(4-hlorofenil)metil]-1-[3-(3H-imidazol-4-il)propilsulfanil]formamidin
Klinički podaci
Identifikatori
CAS broj 145231-45-4
ATC kod nije dodeljen
PubChem[1][2] 2790
ChemSpider[3] 2688
ChEMBL[4] CHEMBL14690
Hemijski podaci
Formula C14H17ClN4S 
Mol. masa 308,83 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Klobenpropit je histaminski antagonist H3 receptora.[5] On ima neuroprotektivno dejstvo, koje ostvaruje putem stimulacije otpuštanja gama-aminobuterne kiseline u mozgu.[6]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining“. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ^ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. ^ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). „The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes“. Eur. J. Pharmacol. 567 (3): 206–10. DOI:10.1016/j.ejphar.2007.04.032. PMID 17537431. 
  6. ^ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European Journal of Pharmacology. 2007 Jun 1;563(1-3):117-23. PMID 17350613

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