TRNK-dihidrouridin 20 sintaza (NAD(P)+)
| TRNA-dihidrouridin 20 sintaza [NAD(P)+] | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.91 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
tRNK-dihidrouridin 20 sintaza [NAD(P)+] (EC 1.3.1.91, Dus2p, tRNK-dihidrouridinska sintaza 2) je enzim sa sistematskim imenom tRNK-5,6-dihidrouracil20:NAD(P)+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5,6-dihidrouracil 20 u tRNK + NAD(P)+ uracil 20 u tRNK + NAD(P)H + H+
Ovaj enzim je flavoenzim. On specifično modifikuje uracil 20 u tRNK.
Reference
[уреди | уреди извор]- ^ Xing, F., Hiley, S.L., Hughes, T.R. and Phizicky, E.M. (2004). „The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs”. J. Biol. Chem. 279: 17850—17860. PMID 14970222.
- ^ Xing, F., Martzen, M.R. and Phizicky, E.M. (2002). „A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA”. RNA. 8: 370—381. PMID 12003496.
- ^ Rider, L.W., Ottosen, M.B., Gattis, S.G. and Palfey, B.A. (2009). „Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction”. J. Biol. Chem. 284: 10324—10333. PMID 19139092.
- ^ Kato, T., Daigo, Y., Hayama, S., Ishikawa, N., Yamabuki, T., Ito, T., Miyamoto, M., Kondo, S. and Nakamura, Y. (2005). „A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis”. Cancer Res. 65: 5638—5646. PMID 15994936.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- TRNA-dihydrouridine20+synthase+(NAD(P)+) на US National Library of Medicine Medical Subject Headings (MeSH)
