MCM2
| Komponenta 2 kompleksa minihromozomskog održavanja | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | MCM2; BM28; CCNL1; CDCL1; D3S3194; MITOTIN; cdc19 | ||||||||||
| Vanjski ID | OMIM: 116945 MGI: 105380 HomoloGene: 3325 GeneCards: MCM2 Gene | ||||||||||
| EC broj | 3.6.4.12 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4171 | 17216 | |||||||||
| Ensembl | ENSG00000073111 | ENSMUSG00000002870 | |||||||||
| UniProt | P49736 | P97310 | |||||||||
| Ref. Sekv. (iRNK) | NM_004526 | NM_008564 | |||||||||
| Ref. Sekv. (protein) | NP_004517 | NP_032590 | |||||||||
| Lokacija (UCSC) |
Chr 3: 127.32 - 127.34 Mb |
Chr 6: 88.88 - 88.9 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Faktor licenciranje DNK replikacije MCM2 je protein koji je kod ljudi kodiran MCM2 genom.
Protein kodiran ovim genom je jedan od visoko konzerviranjih proteina održavanja mini-hromozoma (MCM) koji učestvuju u inicijaciji replikacije eukariotskog genoma. Heksamerni proteinski kompleks formiran od MCM proteina je ključna komponenta prereplikacionog kompleksa. On učestvuje u formiranju replikacionih viljuški i regrutaciji drugih srodnih proteina replikacije DNK[1][2].
Reference[uredi | uredi izvor]
- ^ Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (jul 1991). „Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle”. Biochem Biophys Res Commun. 177 (1): 395—400. PMID 1710453. doi:10.1016/0006-291X(91)91996-P.
- ^ Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (januar 1994). „The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21”. Cytogenet Cell Genet. 65 (4): 276—7. PMID 8258304. doi:10.1159/000133647.
Literatura[uredi | uredi izvor]
- Nomura N; Miyajima N; Sazuka T; et al. (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.”. DNA Res. 1 (1): 27—35. PMID 7584026. doi:10.1093/dnares/1.1.27.
- Nomura N; Miyajima N; Sazuka T; et al. (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).”. DNA Res. 1 (1): 47—56. PMID 7584028. doi:10.1093/dnares/1.1.47.
- Nakatsuru S, Sudo K, Nakamura Y (1995). „Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication.”. Cytogenet. Cell Genet. 68 (3–4): 226—30. PMID 7842741. doi:10.1159/000133918.
- Todorov IT; Pepperkok R; Philipova RN; et al. (1994). „A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division”. J. Cell. Sci. 107 (1): 253—65. PMID 8175912.
- Ishimi Y; Ichinose S; Omori A; et al. (1996). „Binding of human minichromosome maintenance proteins with histone H3”. J. Biol. Chem. 271 (39): 24115—22. PMID 8798650. doi:10.1074/jbc.271.39.24115.
- Fujita M; Yamada C; Tsurumi T; et al. (1998). „Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase”. J. Biol. Chem. 273 (27): 17095—101. PMID 9642275. doi:10.1074/jbc.273.27.17095.
- Jiang W, McDonald D, Hope TJ, Hunter T (1999). „Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication”. EMBO J. 18 (20): 5703—13. PMC 1171637
. PMID 10523313. doi:10.1093/emboj/18.20.5703. - You Z, Komamura Y, Ishimi Y (2000). „Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity”. Mol. Cell. Biol. 19 (12): 8003—15. PMC 84885 . PMID 10567526.
- Ishimi Y; Komamura-Kohno Y; You Z; et al. (2000). „Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2”. J. Biol. Chem. 275 (21): 16235—41. PMID 10748114. doi:10.1074/jbc.M909040199.
- Masai H; Matsui E; You Z; et al. (2000). „Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks”. J. Biol. Chem. 275 (37): 29042—52. PMID 10846177. doi:10.1074/jbc.M002713200.
- Izumi M; Yanagi K; Mizuno T; et al. (2001). „The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase”. Nucleic Acids Res. 28 (23): 4769—77. PMC 115166 . PMID 11095689. doi:10.1093/nar/28.23.4769.
- Burke TW, Cook JG, Asano M, Nevins JR (2001). „Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1”. J. Biol. Chem. 276 (18): 15397—408. PMID 11278932. doi:10.1074/jbc.M011556200.
- Tan DF; Huberman JA; Hyland A; et al. (2002). „MCM2--a promising marker for premalignant lesions of the lung: a cohort study”. BMC Cancer. 1: 6. PMC 35283 . PMID 11472637. doi:10.1186/1471-2407-1-6.
- Ishimi Y, Komamura-Kohno Y, Arai K, Masai H (2001). „Biochemical activities associated with mouse Mcm2 protein”. J. Biol. Chem. 276 (46): 42744—52. PMID 11568184. doi:10.1074/jbc.M106861200.
- Wohlschlegel JA; Dhar SK; Prokhorova TA; et al. (2002). „Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45”. Mol. Cell. 9 (2): 233—40. PMID 11864598. doi:10.1016/S1097-2765(02)00456-2.
- Kodani I; Shomori K; Osaki M; et al. (2002). „Expression of minichromosome maintenance 2 (MCM2), Ki-67, and cell-cycle-related molecules, and apoptosis in the normal-dysplasia-carcinoma sequence of the oral mucosa”. Pathobiology. 69 (3): 150—8. PMID 11872961. doi:10.1159/000048770.
- Edwards MC; Tutter AV; Cvetic C; et al. (2002). „MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts”. J. Biol. Chem. 277 (36): 33049—57. PMID 12087101. doi:10.1074/jbc.M204438200.
- Osaki M; Osaki M; Yamashita H; et al. (2003). „Expression of minichromosome maintenance-2 in human malignant fibrous histiocytomas: Correlations with Ki-67 and P53 expression, and apoptosis”. Int. J. Mol. Med. 10 (2): 161—8. PMID 12119552. doi:10.3892/ijmm.10.2.161.
