ORC3
| Kompleks prepoznavanja mesta početka (ORC) podjedinica 3 N-terminus | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| Simbol | ORC3_N | ||||||||
| Pfam | PF07034 | ||||||||
| InterPro | IPR010748 | ||||||||
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| Kompleks prepoznavanja mesta početka, podjedinica 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | ORC3; LAT; LATHEO; ORC3L | ||||||||||
| Vanjski ID | OMIM: 604972 MGI: 1354944 HomoloGene: 8225 GeneCards: ORC3 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 23595 | 50793 | |||||||||
| Ensembl | ENSG00000135336 | ENSMUSG00000040044 | |||||||||
| UniProt | Q9UBD5 | Q9JK30 | |||||||||
| Ref. Sekv. (iRNK) | NM_001197259 | NM_001159563 | |||||||||
| Ref. Sekv. (protein) | NP_001184188 | NP_001153035 | |||||||||
| Lokacija (UCSC) |
Chr 6: 88.3 - 88.38 Mb |
Chr 4: 34.57 - 34.61 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Kompleks prepoznavanja mesta početka 3 je protein koji je kod ljudi kodiran ORC3 (ORC3L) genom.[1][2][3]
Kompleks prepoznavanja mesta početka (ORC) je visoko konzervisani proteinski kompleks sa šest podjedinica koji je esencijalan za inicijaciju replikacije DNK kod eukariotskih ćelija. Istraživanja na kvascu su pokazala da se ORC specifično vezuje za mesto početka replikacije i da služi kao platforma za konstrukciju prereplikacionog kompleksa, koji sadrži dodatne inicijaciona faktore kao što su Cdc6 i mcm proteini. Protein kodiran ovim genom je podjedinica kompleksa prepoznavanja mesta početka. Studije sličnog gena kod muve Drosophila sugerišu da verovatno učestvuje u neuronskoj proliferaciji i olfaktornoj memoriji. Alternativno splajsovane transkriptne varijante kodiraju distinktne izoforme.[3]
Interakcije[uredi | uredi izvor]
ORC3 formira interakcije sa ORC2,[2][4][5][6][7] MCM7,[4] ORC4,[2][5][7] ORC5,[2][4][5][7] MCM4[4] i ORC6.[4][7]
Reference[uredi | uredi izvor]
- ^ Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (januar 1999). „The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p”. J Biol Chem. 273 (49): 32421—9. PMID 9829972. doi:10.1074/jbc.273.49.32421.
- ^ a b v g Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (jul 1999). „latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant”. Neuron. 23 (1): 45—54. PMID 10402192. doi:10.1016/S0896-6273(00)80752-7.
- ^ a b „Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)”.
- ^ a b v g d Kneissl, Margot; Pütter Vera; et al. (март 2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. England. 327 (1): 111—28. ISSN 0022-2836. PMID 12614612. doi:10.1016/S0022-2836(03)00079-2.
- ^ а б в Dhar, S K; Delmolino L; Dutta A (август 2001). „Architecture of the human origin recognition complex”. J. Biol. Chem. United States. 276 (31): 29067—71. ISSN 0021-9258. PMID 11395502. doi:10.1074/jbc.M103078200.
- ^ Matsuoka, Shuhei; Ballif Bryan A; et al. (maj 2007). „ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage”. Science. United States. 316 (5828): 1160—6. PMID 17525332. doi:10.1126/science.1140321.
- ^ a b v g Vashee, S; Simancek P; et al. (јул 2001). „Assembly of the human origin recognition complex”. J. Biol. Chem. United States. 276 (28): 26666—73. ISSN 0021-9258. PMID 11323433. doi:10.1074/jbc.M102493200.
Литература[uredi | uredi izvor]
- Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171—4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene. 200 (1–2): 149—56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Springer J; Nanda I; Hoehn K; et al. (2000). „Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex”. Cytogenet. Cell Genet. 87 (3–4): 245—51. PMID 10702681. doi:10.1159/000015435.
- Thome KC; Dhar SK; Quintana DG; et al. (2001). „Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins”. J. Biol. Chem. 275 (45): 35233—41. PMID 10954718. doi:10.1074/jbc.M005765200.
- Wiemann S; Weil B; Wellenreuther R; et al. (2001). „Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs”. Genome Res. 11 (3): 422—35. PMC 311072
. PMID 11230166. doi:10.1101/gr.GR1547R. - Vashee S, Simancek P, Challberg MD, Kelly TJ (2001). „Assembly of the human origin recognition complex”. J. Biol. Chem. 276 (28): 26666—73. PMID 11323433. doi:10.1074/jbc.M102493200.
- Dhar SK, Delmolino L, Dutta A (2001). „Architecture of the human origin recognition complex”. J. Biol. Chem. 276 (31): 29067—71. PMID 11395502. doi:10.1074/jbc.M103078200.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Kneissl M, Pütter V, Szalay AA, Grummt F (2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. 327 (1): 111—28. PMID 12614612. doi:10.1016/S0022-2836(03)00079-2.
- Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
- Ramachandran N; Hainsworth E; Bhullar B; et al. (2004). „Self-assembling protein microarrays”. Science. 305 (5680): 86—90. PMID 15232106. doi:10.1126/science.1097639.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Sibani S, Price GB, Zannis-Hadjopoulos M (2005). „Ku80 binds to human replication origins prior to the assembly of the ORC complex”. Biochemistry. 44 (21): 7885—96. PMID 15910003. doi:10.1021/bi047327n.
- Matsuoka S; Ballif BA; Smogorzewska A; et al. (2007). „ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage”. Science. 316 (5828): 1160—6. PMID 17525332. doi:10.1126/science.1140321.
