Pleuromutilin

Pleuromutilin
Nazivi
	IUPAC naziv (4R,5S,6S,8R,9aR,10R)-6-Etenil-5-hidroksi-4,6,9,10-tetrametil-1-oksodekahidro-3a,9-propanociklopenta[8]anulen-8-il hidroksiacetat
Identifikacija
CAS broj	125-65-5 ;
3D model (Jmol)	interaktivna slika;
ECHA InfoCard	100.004.316
PubChem C ID	31326;
	SMILES CC12C(C)CCC3(CCC(=O)C23)C(C)C(O)C(C)(C=C)CC1OC(=O)CO; ; ; ; ; ;
Svojstva
Hemijska formula	C22H34O5
Molarna masa	378,502 g/mol
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Pleuromutilin i njegovi derivati su antibakterijski lekovi koji inhiviraju proteinsku sintezu u bakterijama putem vezivanja za peptidil transferaznu komponentu 50S podjedinicu ribozomas.^[3]^[4]

Ova klasa antibiotika obuhvata retapamulin (odobren za topičku primenu kod ljudi), valnemulin i tiamulin (odobren za upotrebu na životinjama) i lekove koji se istražuju azamulin i BC-3781.

Reference[uredi | uredi izvor]

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. uredi
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Long, Katherine S (april 2006). „Interaction of Pleuromutilin Derivatives with the Ribosomal Peptidyl Transferase Center” (PDF). Antimicrobial Agents and Chemotherapy. 50 (4): 1458—1462. PMC 1426994 . PMID 16569865. doi:10.1128/AAC.50.4.1458-1462.2006. Arhivirano iz originala (PDF) 11. 06. 2011. g. Pristupljeno 17. 11. 2013. |first2= zahteva |last2= u Authors list (pomoć); |first3= zahteva |last3= u Authors list (pomoć); |first4= zahteva |last4= u Authors list (pomoć)
^ Lolk, L.; Pøhlsgaard, J.; Jepsen, A. S.; Hansen, L. H.; Nielsen, H.; Steffansen, S. I.; Sparving, L.; Nielsen, A. B.; Vester, B.; Nielsen, P. (2008). „A Click Chemistry Approach to Pleuromutilin Conjugates with Nucleosides or Acyclic Nucleoside Derivatives and Their Binding to the Bacterial Ribosome”. Journal of Medicinal Chemistry. 51 (16): 4957—4967. PMID 18680270. doi:10.1021/jm800261u.

Spoljašnje veze[uredi | uredi izvor]

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. uredi

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[3] Long, Katherine S (april 2006). „Interaction of Pleuromutilin Derivatives with the Ribosomal Peptidyl Transferase Center” (PDF). Antimicrobial Agents and Chemotherapy. 50 (4): 1458—1462. PMC 1426994 . PMID 16569865. doi:10.1128/AAC.50.4.1458-1462.2006. Arhivirano iz originala (PDF) 11. 06. 2011. g. Pristupljeno 17. 11. 2013. |first2= zahteva |last2= u Authors list (pomoć); |first3= zahteva |last3= u Authors list (pomoć); |first4= zahteva |last4= u Authors list (pomoć)

[4] Lolk, L.; Pøhlsgaard, J.; Jepsen, A. S.; Hansen, L. H.; Nielsen, H.; Steffansen, S. I.; Sparving, L.; Nielsen, A. B.; Vester, B.; Nielsen, P. (2008). „A Click Chemistry Approach to Pleuromutilin Conjugates with Nucleosides or Acyclic Nucleoside Derivatives and Their Binding to the Bacterial Ribosome”. Journal of Medicinal Chemistry. 51 (16): 4957—4967. PMID 18680270. doi:10.1021/jm800261u.

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