Hloramfenikol

Hloramfenikol
Klinički podaci
Prodajno ime	Ak-chlor, Ak-Chlor Ophthalmic Ointment, Ak-Chlor Ophthalmic Solution, Alficetyn
Drugs.com	Monografija
Način primene	Oftalmički, intramuskularno
Identifikatori
CAS broj	56-75-7
ATC kod	D06AX02 (WHO), S03AA08
PubChem	CID 298
DrugBank	DB00446
ChemSpider	5744
KEGG	C00918
ChEBI	CHEBI:17698
ChEMBL	CHEMBL130

Hloramfenikol je organsko jedinjenje, koje sadrži 11 atoma ugljenika i ima molekulsku masu od 323,129 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	5
Broj donora vodonika	3
Broj rotacionih veza	6
Particioni koeficijent^[8] (ALogP)	1,0
Rastvorljivost^[9] (logS, log(mol/L))	-4,1
Polarna površina^[10] (PSA, Å²)	115,4

Reference

^ Bhutta, Z. A.; Niazi, S. K.; Suria, A. (1992). „Chloramphenicol clearance in typhoid fever: Implications for therapy”. Indian Journal of Pediatrics. 59 (2): 213—9. PMID 1398851. S2CID 13369284. doi:10.1007/BF02759987.
^ Wali, S. S.; MacFarlane, J. T.; Weir, W. R.; Cleland, P. G.; Ball, P. A.; Hassan-King, M.; Whittle, H. C.; Greenwood, B. M. (1979). „Single injection treatment of meningococcal meningitis. 2. Long-acting chloramphenicol”. Transactions of the Royal Society of Tropical Medicine and Hygiene. 73 (6): 698—702. PMID 538813. doi:10.1016/0035-9203(79)90024-5.
^ Puddicombe, J. B.; Wali, S. S.; Greenwood, B. M. (1984). „A field trial of a single intramuscular injection of long-acting chloramphenicol in the treatment of meningococcal meningitis”. Transactions of the Royal Society of Tropical Medicine and Hygiene. 78 (3): 399—403. PMID 6464136. doi:10.1016/0035-9203(84)90132-9.
^ Pécoul, B.; Varaine, F.; Keita, M.; Soga, G.; Djibo, A.; Soula, G.; Abdou, A.; Etienne, J.; Rey, M. (1991-10-05). „Long-acting chloramphenicol versus intravenous ampicillin for treatment of bacterial meningitis”. Lancet (London, England). 338 (8771): 862—6. PMID 1681224. S2CID 31211632. doi:10.1016/0140-6736(91)91511-r.
^ Nathan, N.; Borel, T.; Djibo, A.; Evans, D.; Djibo, S.; Corty, J. F.; Guillerm, M.; Alberti, K. P.; Pinoges, L.; Guerin, P. J.; Legros, D. (2005). „Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: A randomised non-inferiority study”. Lancet (London, England). 366 (9482): 308—13. PMID 16039333. S2CID 20885088. doi:10.1016/S0140-6736(05)66792-X.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Chloramphenicol Архивирано на веб-сајту Wayback Machine (11. август 2020)

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[1] Bhutta, Z. A.; Niazi, S. K.; Suria, A. (1992). „Chloramphenicol clearance in typhoid fever: Implications for therapy”. Indian Journal of Pediatrics. 59 (2): 213—9. PMID 1398851. S2CID 13369284. doi:10.1007/BF02759987.

[2] Wali, S. S.; MacFarlane, J. T.; Weir, W. R.; Cleland, P. G.; Ball, P. A.; Hassan-King, M.; Whittle, H. C.; Greenwood, B. M. (1979). „Single injection treatment of meningococcal meningitis. 2. Long-acting chloramphenicol”. Transactions of the Royal Society of Tropical Medicine and Hygiene. 73 (6): 698—702. PMID 538813. doi:10.1016/0035-9203(79)90024-5.

[3] Puddicombe, J. B.; Wali, S. S.; Greenwood, B. M. (1984). „A field trial of a single intramuscular injection of long-acting chloramphenicol in the treatment of meningococcal meningitis”. Transactions of the Royal Society of Tropical Medicine and Hygiene. 78 (3): 399—403. PMID 6464136. doi:10.1016/0035-9203(84)90132-9.

[4] Pécoul, B.; Varaine, F.; Keita, M.; Soga, G.; Djibo, A.; Soula, G.; Abdou, A.; Etienne, J.; Rey, M. (1991-10-05). „Long-acting chloramphenicol versus intravenous ampicillin for treatment of bacterial meningitis”. Lancet (London, England). 338 (8771): 862—6. PMID 1681224. S2CID 31211632. doi:10.1016/0140-6736(91)91511-r.

[5] Nathan, N.; Borel, T.; Djibo, A.; Evans, D.; Djibo, S.; Corty, J. F.; Guillerm, M.; Alberti, K. P.; Pinoges, L.; Guerin, P. J.; Legros, D. (2005). „Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: A randomised non-inferiority study”. Lancet (London, England). 366 (9482): 308—13. PMID 16039333. S2CID 20885088. doi:10.1016/S0140-6736(05)66792-X.

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[9] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[10] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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