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Rolofilin

S Vikipedije, slobodne enciklopedije
Rolofilin
IUPAC ime
8-(Heksahidro-2,5-metanopentalen-3a(1H)-il)-3,7-dihidro-1,3-dipropil-1H-purin-2,6-dion
Pravni status
Pravni status
Identifikatori
CAS broj136199-02-5 DaY
ATC kodC03BD (WHO)
PubChemCID 64627
ChemSpider58188
UNII7805S5HIHX DaY
Hemijski podaci
FormulaC20H28N4O2
Molarna masa356,46 g/mol

Rolofilin (KW-3902) je eksperimentalni diuretik koji deluje kao selektivni antagonist adenozinskog A1 receptora.[1][2]

Reference

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  1. ^ Givertz MM, Massie BM, Fields TK, Pearson LL, Dittrich HC (2007). „The effects of KW-3902, an adenosine A1-receptor antagonist,on diuresis and renal function in patients with acute decompensated heart failure and renal impairment or diuretic resistance”. J. Am. Coll. Cardiol. 50 (16): 1551—60. PMID 17936154. doi:10.1016/j.jacc.2007.07.019. 
  2. ^ Cotter G, Dittrich HC, Weatherley BD, Bloomfield DM, O'Connor CM, Metra M, Massie BM (2008). „The PROTECT pilot study: a randomized, placebo-controlled, dose-finding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal impairment”. Journal of Cardiac Failure. 14 (8): 631—40. PMID 18926433. doi:10.1016/j.cardfail.2008.08.010. 

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