Fluklorolon acetonid

Fluklorolon acetonid
Klinički podaci
Drugs.com	acetonide.html Monografija
Identifikatori
CAS broj	3693-39-8
ATC kod	D07AC02 (WHO)
PubChem	CID 20054914
UNII	MG258KTA37
Hemijski podaci
Formula	C24H29Cl2FO5
Molarna masa	487,388
	SMILES CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(Cl)[C@@H](Cl)C[C@]3(C)[C@@]2(O1)C(=O)CO; ;
	InChI InChI=1S/C24H29Cl2FO5/c1-20(2)31-19-9-13-14-8-16(27)15-7-12(29)5-6-21(15,3)23(14,26)17(25)10-22(13,4)24(19,32-20)18(30)11-28/h5-7,13-14,16-17,19,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1; Key:NJNWEGFJCGYWQT-VSXGLTOVSA-N ;

Fluklorolon acetonid (INN, ili flukloronid, USAN, s prodajnim imenima Cutanit, Topicon) kortikosteroid je za topikalnu primenu na koži.^[1]

Slobodni fluklorolon, bez acetonida (C₂₁H₂₅Cl₂FO₅, PubChem 60900)

Osobine

Fluklorolon acetonid je organsko jedinjenje, koje sadrži 24 atoma ugljenika i ima molekulsku masu od 487,388 Da.

Osobina	Vrednost
Broj akceptora vodonika	5
Broj donora vodonika	1
Broj rotacionih veza	2
Particioni koeficijent^[2] (ALogP)	2,5
Rastvorljivost^[3] (logS, log(mol/L))	-6,7
Polarna površina^[4] (PSA, Å²)	72,8

Reference

^ Cunliffe, W. J. (1976). . „Long-term treatment with 0-01% fluclorolone acetonide in children”. British Medical Journal. 1 (6010): 627. PMC 1639042 . PMID 1252855. doi:10.1136/bmj.1.6010.627.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci.. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). . „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem.. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Fluclorolone acetonide

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Cunliffe, W. J. (1976). . „Long-term treatment with 0-01% fluclorolone acetonide in children”. British Medical Journal. 1 (6010): 627. PMC 1639042 . PMID 1252855. doi:10.1136/bmj.1.6010.627.

[2] Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.

[3] Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci.. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[4] Ertl P.; Rohde B.; Selzer P. (2000). . „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem.. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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