Hinoprotein glukoza dehidrogenaza

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Hinoprotein glukoza dehidrogenaza
Identifikatori
EC broj1.1.5.2
CAS broj81669-60-5
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBsum

Hinoprotein glukoza dehidrogenaza (EC 1.1.5.2, membranska glukozna dehidrogenaza, mGDH, glukozna dehidrogenaza (PQQ-zavisna), glukozna dehidrogenaza (pirolohinolin-hinon), hinoproteinska D-glukozna dehidrogenaza) je enzim sa sistematskim imenom D-glukoza:ubihinon oksidoreduktaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju

D-glukoza + ubihinon D-glukono-1,5-lakton + ubihinol

Ovaj integralni membranski protein sadrži PQQ kao prostetičku grupu. On takođe sadrži vezan ubihinon i Mg2+ ili Ca2+. Elektronski akceptor je membranski ubihinon.

Reference[уреди]

  1. ^ Yamada, M., Sumi, K., Matsushita, K., Adachi, O. and Yamada, Y. (1993). „Topological analysis of quinoprotein glucose-dehydrogenase in Escherichia coli and its ubiquinone-binding site”. J. Biol. Chem. 268: 12812—12817. PMID 8509415. 
  2. ^ Dewanti, A.R. & Duine, J.A. (1998). „Reconstitution of membrane-integrated quinoprotein glucose dehydrogenase apoenzyme with PQQ and the holoenzyme's mechanism of action”. Biochemistry. 37: 6810—6818. PMID 9578566. 
  3. ^ Duine, J.A., Frank, J. and Van Zeeland, J.K. (1979). „Glucose dehydrogenase from Acinetobacter calcoaceticus: a 'quinoprotein'”. FEBS Lett. 108: 443—446. PMID 520586. 
  4. ^ Ameyama, M., Matsushita, K., Ohno, Y., Shinagawa, E. and Adachi, O. (1981). „Existence of a novel prosthetic group, PQQ, in membrane-bound, electron transport chain-linked, primary dehydrogenases of oxidative bacteria”. FEBS Lett. 130: 179—183. PMID 6793395. 
  5. ^ Cozier, G.E. & Anthony, C. (1995). „Structure of the quinoprotein glucose dehydrogenase of Escherichia coli modelled on that of methanol dehydrogenase from Methylobacterium extorquens”. Biochem. J. 312: 679—685. PMID 8554505. 
  6. ^ Cozier, G.E., Salleh, R.A. and Anthony, C. (1999). „Characterization of the membrane quinoprotein glucose dehydrogenase from Escherichia coli and characterization of a site-directed mutant in which histidine-262 has been changed to tyrosine”. Biochem. J. 340: 639—647. PMID 10359647. 
  7. ^ Elias, M.D., Tanaka, M., Sakai, M., Toyama, H., Matsushita, K., Adachi, O. and Yamada, M. (2001). „C-terminal periplasmic domain of Escherichia coli quinoprotein glucose dehydrogenase transfers electrons to ubiquinone”. J. Biol. Chem. 276: 48356—48361. PMID 11604400. 
  8. ^ James, P.L. & Anthony, C. (2003). „The metal ion in the active site of the membrane glucose dehydrogenase of Escherichia coli”. Biochim. Biophys. Acta. 1647: 200—205. PMID 12686133. 
  9. ^ Elias, M.D., Nakamura, S., Migita, C.T., Miyoshi, H., Toyama, H., Matsushita, K., Adachi, O. and Yamada, M. (2004). „Occurrence of a bound ubiquinone and its function in Escherichia coli membrane-bound quinoprotein glucose dehydrogenase”. J. Biol. Chem. 279: 3078—3083. PMID 14612441. 
  10. ^ Mustafa, G., Ishikawa, Y., Kobayashi, K., Migita, C.T., Elias, M.D., Nakamura, S., Tagawa, S. and Yamada, M. (2008). „Amino acid residues interacting with both the bound quinone and coenzyme, pyrroloquinoline quinone, in Escherichia coli membrane-bound glucose dehydrogenase”. J. Biol. Chem. 283: 22215—22221. PMID 18550551. 

Literatura[уреди]

Spoljašnje veze[уреди]