HMG-CoA reduktaza

3-hidroksi-3-metilglutaril-CoA reduktaza
PDB prikaz baziran na 1dq8.
Dostupne strukture
1DQ8, 1DQ9, 1DQA, 1HW8, 1HW9, 1HWI, 1HWJ, 1HWK, 1HWL, 2Q1L, 2Q6B, 2Q6C, 2R4F, 3BGL, 3CCT, 3CCW, 3CCZ, 3CD0, 3CD5, 3CD7, 3CDA, 3CDB
Identifikatori
Simboli	HMGCR; LDLCQ3
Vanjski ID	OMIM: 142910 MGI: 96159 HomoloGene: 30994 GeneCards: HMGCR Gene
EC broj	1.1.1.34
Ontologija gena Molekularna funkcija • aktivnost hidroksimetilglutaril-CoA reduktaze (NADPH) • aktivnost hidroksimetilglutaril-CoA reduktaze • aktivnost proteinske homodimerizacije • vezivanje koenzima • NADPH vezivanje Celularna komponenta • peroksizomalna membrana • endoplazmatični retikulum • membrana endoplazmatičnog retikuluma • integralno sa membranom Biološki proces • proces holesterolne biosinteze • starenje • respons na nutrijent • proces izoprenoidne biosinteze
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	3156	15357
Ensembl	ENSG00000113161	ENSMUSG00000021670
UniProt	P04035	E9PVG9
RefSeq (mRNA)	NM_000859.2	NM_008255.2
RefSeq (protein)	NP_000850.1	NP_032281.2
Lokacija (UCSC)	Chr 5: 74.63 - 74.66 Mb	Chr 13: 96.65 - 96.67 Mb
PubMed pretraga	[1]	[2]

HMG-CoA reduktaza
EC broj	{{{EC_number}}}
Ontologija gena	AmiGO / EGO

hydroxymethylglutaryl-CoA reduktaza
Identifikatori
EC broj	1.1.1.88
CAS broj	37250-24-1
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Ontologija gena	AmiGO / EGO
Pretraga PMC članci PubMed članci NCBI proteini

HMG-CoA reduktaza (3-hidroksi-3-metil-glutaril-CoA reduktaza, HMGCR) je enzim (EC 1.1.1.88) koji ograničava brzinu mevalonatnog puta, metaboličkog puta koji proizvodi holesterol i druge izoprenoide. Normalno je u ćelijama sisara ovaj enzim supresovan holesterolom koji potiče iz internalizacije i degradacije lipoproteina niske gustine (LDL) putem LDL receptora, kao i oksidovanim vrstama holesterola. Kompetitivni inhibitori reduktaze indukuju izražavanje LDL receptora u jeri, čime se povećava katabolizam LDL-a u plazmi, te se snižava koncentracija holesterola u plazmi, što je važna odrednica ateroskleroze.

Ovaj enzim je biološka meta široko dostupnih lekova za snižavanje nivoa holesterola, kolektivno poznatih kao statini. HMG-CoA reduktaza ze vezana za membranu endoplazmatičnog retikuluma, i dugo se mislilo da ima sedam transmembranskih domena, sa aktivnim mestom lociranim na njenom dugačkom karboksilnom domenu u citozolu. Nedavni nalazi su pokazali da sadrži osam transmembranskih domena.

Literatura

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Vidi još

• Oksidoreduktaza

Spoljašnje veze

• Cholesterol Synthesis Архивирано на сајту Wayback Machine (4. јул 2017) - has some good regulatory details
• Proteopedia HMG-CoA_Reductase - the HMG-CoA Reductase Structure in Interactive 3D