PFKL
| Fosfofruktokinaza, jetra | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | PFKL; ATP-PFK; PFK-B; PFK-L | ||||||||||
| Vanjski ID | OMIM: 171860 MGI: 97547 HomoloGene: 55668 GeneCards: PFKL Gene | ||||||||||
| EC broj | 2.7.1.11 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5211 | 18641 | |||||||||
| Ensembl | ENSG00000141959 | ENSMUSG00000020277 | |||||||||
| UniProt | P17858 | P12382 | |||||||||
| RefSeq (mRNA) | NM_001002021 | NM_008826 | |||||||||
| RefSeq (protein) | NP_001002021 | NP_032852 | |||||||||
| Lokacija (UCSC) |
Chr 21: 45.72 - 45.75 Mb |
Chr 10: 77.99 - 78.01 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
6-Fosfofruktokinaza, jetreni tip je enzim koji je kod ljudi kodiran PFKL genom.[1]
Fosfofruktokinaza (PFK) je tetramerni enzim koji katalizuje ključni korak u glikolizi, konverziju D-fruktoze 6-fosfata do D-fruktoze 1,6-bisfosfata. Zasebni genei kodiraju mišićnu podjedinicu (M) i jetrenu podjedinicu (L). PFK iz mišića je homotetramer M podjedinica, PFK iz jetre je homotetramer L-jedinica, dok se PFK iz trombocita može sastojati od bilo koje tetramerne kombinacije M i L podjedinica. Protein kodiran ovim genom je L podjedinica. Dve transkriptne varijante koje kodiraju različite izoforme su poznate.[1]
Reference[уреди | уреди извор]
Literatura[уреди | уреди извор]
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