Inhibitor GABA transaminaze
Inhibitor GABA transaminaze je enzimski inhibitor koji deluje na GABA transaminazu.[1]
Primeri inhibitora GABA transaminaze su Valproinska kiselina,[2] vigabatrin,[3][4] feniletilidenhidrazin, etanolamin-O-sulfat (EOS), i L-cikloserin.[5]
Pojedini članovi ove klase se koriste kao antikonvulsanti. Postoji izvesna evidencija da Melissa officinalis i rozmarinska kiselina koju sadrži, inhibiraju GABA transaminaze.
Reference[уреди | уреди извор]
- ^ Ciesielski, L.; Simler, S.; Gensburger, C.; Mandel, P.; Taillandier, G.; Benoit-Guyod, J. L.; Boucherle, A.; Cohen-Addad, C.; Lajzerowicz, J. (1979). „GABA Transaminase Inhibitors”. GABA—Biochemistry and CNS Functions. Advances in Experimental Medicine and Biology. 123. стр. 21—41. ISBN 978-1-4899-5201-1. PMID 390993. doi:10.1007/978-1-4899-5199-1_2.
- ^ Bruni, J.; Wilder, B. J. (1979). „Valproic acid. Review of a new antiepileptic drug”. Archives of Neurology. 36 (7): 393—398. PMID 110294. doi:10.1001/archneur.1979.00500430023002.
- ^ Wang QP, Jammoul F, Duboc A, et al. (април 2008). „Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina”. Eur. J. Neurosci. 27 (8): 2177—87. PMC 2933832
. PMID 18412635. doi:10.1111/j.1460-9568.2008.06175.x.
- ^ Gibson, J. P.; Yarrington, J. T.; Loudy, D. E.; Gerbig, C. G.; Hurst, G. H.; Newberne, J. W. (1990). „Chronic toxicity studies with vigabatrin, a GABA-transaminase inhibitor”. Toxicologic Pathology. 18 (2): 225—238. PMID 2399411. doi:10.1177/019262339001800201 .
- ^ Polc, P.; Pieri, L.; Bonetti, E. P.; Scherschlicht, R.; Moehler, H.; Kettler, R.; Burkard, W.; Haefely, W. (1986). „L-cycloserine: Behavioural and biochemical effects after single and repeated administration to mice, rats and cats”. Neuropharmacology. 25 (4): 411—418. PMID 3012401. S2CID 462885. doi:10.1016/0028-3908(86)90236-4.
