2,3-Bisfosfoglicerinska kiselina

2,3-Bisfosfoglicerinska kiselina
Nazivi
	IUPAC naziv 2,3-Bisfosfoglicerat
	Drugi nazivi 2,3-Difosfoglicerna kiselina; 2,3-Difosfoglicerat; 2,3-Bisfosfoglicerat
Identifikacija
CAS broj	138-81-8 ;
3D model (Jmol)	interaktivna slika;
Abrevijacija	2,3-BPG; 2,3-DPG; 23BPG
ChEBI	CHEBI:17720 ;
ChemSpider	161681 ; 60 (Racemat);
PubChem C ID	61;
	SMILES O=P(O)(OC(C(=O)O)COP(=O)(O)O)O; ; ; ; ; ;
Svojstva
Hemijska formula	C3H8O10P2
Molarna masa	266,03 g·mol−1
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

2,3-Bisfosfoglicerinska kiselina (2,3-Bisfosfoglicerat, 2,3-BPG, 2,3-difosfoglicerat, 2,3-DPG) je trougljenični izomer glikolitičkog intermediera 1,3-bisfosfoglicerinska kiselina (1,3-BPG). 2,3-BPG je prisutna u ljudskim crvenim krvnim zrncima (RBC; eritrocitima) na nivou od približno 5 mmol/L. Ona se vezuje sa velikim afinitetom za dezoksigenisani hemoglobin (e.g. kad su crvena krvna zrnca blizo plučnog tkiva).

Funkcija 2,3-bisfosfoglicerinske kiseline je otkrivena 1967.^[3]

Reference

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Benesch, R.; Benesch, R. E. (1967). „The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin”. Biochem Biophys Res Commun. 26 (2): 162—7. PMID 6030262. doi:10.1016/0006-291X(67)90228-8.

Literatura

Berg, J.M.; Tymockzko, J.L.; Stryer, L. (1995). Biochemistry (5th изд.). W.H. Freeman and Co, New York. ISBN 978-0-7167-4684-3.
„Online medical dictionary”. Архивирано из оригинала 10. 09. 2006. г.
David L. Nelson; Michael M. Cox (2005). Principles of Biochemistry (IV изд.). New York: W. H. Freeman. ISBN 0-7167-4339-6.
Muller-esterl, W. (2008). Biochemistry: Fundamentals Of Medicine And The Science Of Life (2nd изд.). Reverté. ISBN 978-84-291-7393-2.
Bernadette F. Rodak (2003). Hematology. Clinical principles and applications (2nd изд.). Philadelphia: Elsevier Science. ISBN 978-950-06-1876-2.
González-Cinca N, Pérez de la Ossa P, Carreras J, Climent F."Effects of thyroid hormone and hypoxia on 2,3-bisphosphoglycerate, bisphosphoglycerate synthase and phosphoglycerate mutase in rabbit erythroblasts and reticulocytes in vivo". Unitat de Bioquímica, Departament de Ciéncies Fisiològiques I, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain, 2004.
Nielsen AL, Andersen EM, Jørgensen LG, Jensen HA. "Oxygen and 2,3 biphosphoglycerate (2,3-BPG) during haemodialysis". Department of Nephrology, Hvidovre University Hospital, Denmark, 1998.
"Anales de la Real Academia Nacional de Medicina (cuaderno cuarto)". ISSN 0034-0634

Spoljašnje veze

„A live model of the effect of changing 2,3 BPG on the oxyhaemoglobin saturation curve”. Архивирано из оригинала 31. 08. 2010. г.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[Benesch1967-3] Benesch, R.; Benesch, R. E. (1967). „The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin”. Biochem Biophys Res Commun. 26 (2): 162—7. PMID 6030262. doi:10.1016/0006-291X(67)90228-8.

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