CXCL7

Из Википедије, слободне енциклопедије
Pro-trombocit bazični protein (hemokin (C-X-C motiv) ligand 7)

PDB prikaz baziran na 1f9p.
Dostupne strukture
1f9p, 1nap, 1tvx
Identifikatori
Simboli PPBP; PBP; B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
Vanjski ID OMIM121010 MGI1888712 HomoloGene48122 GeneCards: PPBP Gene
Pregled RNK izražavanja
PBB GE PPBP 214146 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5473 57349
Ensembl ENSG00000163736 ENSMUSG00000029372
UniProt P02775 n/a
RefSeq (mRNA) NM_002704 NM_023785
RefSeq (protein) NP_002695 NP_076274
Lokacija (UCSC) Chr 4:
75.07 - 75.07 Mb
Chr 5:
91.84 - 91.85 Mb
PubMed pretraga [1] [2]

CXCL7, hemokin (C-X-C motiv) ligand 7, je ljudski gen[1] koji kodira istoimeni protein. CXCL7 je mali citokin iz CXC hemokin familije. On je izoforma beta-tromboglobulina ili protrombocit bazični protein (PPBP).[2][3]

CXCL7 protein se oslobađa u velikim količinama iz trombocita nakon njihove aktivacije.[4] On stimuliše razne procese uključujući mitogenezu, sintezu ekstracelularnog matriksa, metabolizam glukoze i sintezu plazminogen aktivatora.[5][6]

Reference[уреди]

  1. ^ „Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)“. 
  2. ^ Hristov M, Zernecke A, Bidzhekov K, et al. (March 2007). „Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury“. Circ. Res. 100 (4): 590–7. DOI:10.1161/01.RES.0000259043.42571.68. PMID 17272812. 
  3. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ed. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  4. ^ Majumdar S, Gonder D, Koutsis B, Poncz M (1991). „Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4“. J Biol Chem 266 (9): 5785–9. PMID 1826003. 
  5. ^ Castor C, Miller J, Walz D (1983). „Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor“. Proc Natl Acad Sci USA 80 (3): 765–9. DOI:10.1073/pnas.80.3.765. PMC 393460. PMID 6572368. 
  6. ^ Castor C, Furlong A, Carter-Su C (1985). „Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III“. Biochemistry 24 (7): 1762–7. DOI:10.1021/bi00328a029. PMID 4005226. 

Literatura[уреди]

Spoljašnje veze[уреди]