Kardiotrofin 1

Kardiotrofin-1 (CT-1) je citokin. On je srčani hipertrofni faktor sa 21.5 kDa, i član IL-6 citokinske familije. CT-1 je povezan sa patofiziologijom srčanih bolesti^[1], kao što su hipertenzija, miokardijalna infarkcija, valvularna srčana mana, and kongestivna srčana slabost. Ovaj protein deluje putem interakcije sa glikoproteinom 130 (gp130)/leukemijskim inhibitornim faktorom receptor beta (LIFR) heterodimera. Dodatno, CT-1 aktivira fosfatidilinozitol 3-kinazu (PI-3 kinaza) u srčanim mišićima i pojačava DNK-vezivanje transkripcionog faktora NF-κB. CT-1 je visoko izražen u srcu, skeletalnim mišićima^[2], prostati i jajnicima, i u manjoj meri u plućima, bubrezima, pankreasu, timusu, testisima i tankim crevima.^[3]^[4]^[5]

Literatura [уреди]

^ Ronald W. Oppenheim, Stefan Wiese, David Prevette, Mark Armanini, Siwei Wang, Lucien J. Houenou, Bettina Holtmann, Rudolf Götz, Diane Pennica, and Michael Sendtner (2001). „Cardiotrophin-1, a Muscle-Derived Cytokine, Is Required for the Survival of Subpopulations of Developing Motoneurons“. The Journal of Neuroscience 2 (4): 283-29.
^ Tian Li, Larisa M. Wiggins, and Christopher S. von Bartheld (2010). „Insulin-like Growth Factor-1 and Cardiotrophin 1 Increase Strength and Mass of Extraocular Muscle in Juvenile Chicken“. Investigative Ophthalmology and Visual Science 51: 2479-2486. DOI:10.1167/iovs.09-4414.
^ „Cardiotrophin-1 (CT-1)“
^ Freed DH, Moon MC, Borowiec AM, Jones SC, Zahradka P, Dixon IM. (2003). „Cardiotrophin-1: expression in experimental myocardial infarction and potential role in post-MI wound healing“. Mol Cell Biochem 254 (1-2): 247-56. PMID 14674704.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ed. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.