Glaucin

Из Википедије, слободне енциклопедије
Glaucin
Glaucine.svg
IUPAC ime
(S)-5,6,6a,7-tetrahidro-1,2,9,10-tetrametoksi-6-metil-4H-dibenzo[de,g]hinolin
Klinički podaci
Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 475-81-0 ДаY
5630-11-5
ATC kod none
PubChem CID 16754
ChemSpider 15883 НеН
UNII NU19306XA7 ДаY
ChEMBL CHEMBL228082 ДаY
NIAID ChemDB 011385
Hemijski podaci
Formula C21H25NO4
Molarna masa 355,428 g/mol
  (verify)

Glaucin je alkaloid prisutan u nekoliko različitih vrsta biljki kao što su Glaucium flavum[1], Glaucium oxylobum,[2] Croton lechleri[3] i Corydalis yanhusuo.[4] On ima bronhodilatatorske i antiinflamatorne efekte, usled delovanja kao PDE4 inhibitor i blokator kalcijumovog kanala,[5] i koristi se kao antitusik u nekim zemljama.[6] Glaucin može da ima nuspojave poput sedacije, umora, i halucinogena dejstva karakterisana burnim vizuelnim prikazima,[7][8] i od nedavno je zabeležena njegova upotreba kao droge.[9]

Reference[уреди]

  1. G.B. Lapa; O.P. Sheichenko; A.G. Serezhechkin & O.N. Tolkachev (2004). „HPLC Determination of Glaucine in Yellow Horn Poppy Grass (Glaucium flavum Crantz)”. Pharmaceutical Chemistry Journal. 38 (1): 441—442. ISSN 0091-150X. doi:10.1023/B:PHAC.0000048907.58847.c6. Приступљено 14. 6. 2009. »S-(+)-Glaucine (C21H25NO4) is the main alkaloid component in the grass of yellow horn poppy (Glaucium luteum L., syn. Glaucium flavum Crantz) of the Papaveraceae family« 
  2. -{Morteza-Semnani K, Amin G, Shidfar MR, Hadizadeh H, Shafiee A. Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum. Fitoterapia. 2003 Jul;74(5):493-6. PMID 12837370
  3. Milanowski DJ, Winter RE, Elvin-Lewis MP, Lewis WH. Geographic distribution of three alkaloid chemotypes of Croton lechleri. Journal of Natural Products. 2002 Jun;65(6):814-9. PMID 12088421
  4. Xu XH, Yu GD, Wang ZT. Resource investigation and quality evaluation on wild Corydalis yanhusuo. (Chinese). Zhongguo Zhong Yao Za Zhi. 2004 May;29(5):399-401. PMID 15706885
  5. Cortijo J, Villagrasa V, Pons R, Berto L, Martí-Cabrera M, Martinez-Losa M, Domenech T, Beleta J, Morcillo EJ. Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes. British Journal of Pharmacology. 1999 Aug;127(7):1641-51. PMID 10455321
  6. Rühle KH, Criscuolo D, Dieterich HA, Köhler D, Riedel G. Objective evaluation of dextromethorphan and glaucine as antitussive agents. British Journal of Clinical Pharmacology. 1984 May;17(5):521-4. PMID 6375709
  7. Rovinskiĭ VI. A case of hallucinogen-like action of glaucine. (Russian). Klinicheskaia Meditsina (Mosk). 1989 Sep;67(9):107-8. PMID 2586025
  8. Rovinskiĭ VI. Acute glaucine syndrome in the physician's practice: the clinical picture and potential danger. (Russian). Klinicheskaia Meditsina (Mosk). 2006;84(11):68-70. PMID 17243616
  9. Dargan PI, Button J, Hawkins L, Archer JR, Ovaska H, Lidder S, Ramsey J, Holt DW, Wood DM. Detection of the pharmaceutical agent glaucine as a recreational drug. European Journal of Clinical Pharmacology. 2008 May;64(5):553-4. PMID 18204834

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