Nantenin

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Nantenin
Nantenine.png
IUPAC ime
(S)-1,2-Dimetoksi-6-metil-5,6,6a,7-tetrahidro-4H-benzo[de][1,3]benzodioksolo[5,6-g]quinolin
Identifikatori
CAS broj 2565-01-7 ДаY
ATC kod none
PubChem CID 197001
ChEMBL CHEMBL467094 ДаY
Hemijski podaci
Formula C20H21NO4
Molarna masa 339,385 g/mol
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Nantenin je alkaloid nađen u biljci Nandina domestica[1] kao i u nekim Corydalis vrstama.[2] On je antagonist α1 adrenergičkog receptroa[3] i 5-HT2A serotoninskog receptora,[4] i blokira bihevioralne i fiziološke efekte MDMA kod životinja.[5]

Reference[уреди]

  1. Shoji N, Umeyama A, Takemoto T, Ohizumi Y (1984). „Serotonergic receptor antagonist from Nandina domestica Thunberg”. Journal of Pharmaceutical Sciences. 73 (4): 568—70. PMID 6726648. doi:10.1002/jps.2600730435. 
  2. Kiryakov HG, Iskrenova E, Daskalova E, Kuzmanov B, Evstatieva L (1982). „Alkaloids of Corydalis slivenensis”. Planta Medica. 44 (3): 168—70. PMID 17402105. doi:10.1055/s-2007-971432. 
  3. Indra B, Matsunaga K, Hoshino O, Suzuki M, Ogasawara H, Ohizumi Y (2002). „Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity”. European Journal of Pharmacology. 437 (3): 173—8. PMID 11890906. doi:10.1016/S0014-2999(02)01303-1. 
  4. Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW (2009). „(+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners”. Bioorganic & Medicinal Chemistry Letters. 19 (9): 2530—2. PMC 2677726Слободан приступ. PMID 19328689. doi:10.1016/j.bmcl.2009.03.048. 
  5. Fantegrossi WE, Kiessel CL, Leach PT, Van Martin C, Karabenick RL, Chen X, Ohizumi Y, Ullrich T, Rice KC, Woods JH (2004). „Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice”. Psychopharmacology. 173 (3-4): 270—7. PMID 14740148. doi:10.1007/s00213-003-1741-2. 

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