FZD2
| Uvojiti receptor 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | FZD2; Fz2; fz-2; fzE2; hFz2 | ||||||||||
| Vanjski ID | OMIM: 600667 MGI: 1888513 HomoloGene: 20377 IUPHAR: FZD2 GeneCards: FZD2 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2535 | 57265 | |||||||||
| Ensembl | ENSG00000180340 | ENSMUSG00000050288 | |||||||||
| UniProt | Q14332 | Q9JIP6 | |||||||||
| RefSeq (mRNA) | NM_001466.3 | NM_020510.2 | |||||||||
| RefSeq (protein) | NP_001457.1 | NP_065256.1 | |||||||||
| Lokacija (UCSC) |
Chr 17: 42.63 - 42.64 Mb |
Chr 11: 102.47 - 102.47 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Uvojiti-2 je protein koji je kod ljudi kodiran FZD2 genom.[1][2][3]
Članovi familije 'uvojitih' proteina su 7-transmembranski receptori za Wnt signalne proteine. Izražavanje FZD2 gena je razvojno regulisano, sa visokim nivoima izraženim u bubrezima i plučima fetusa, i u crevima i jajnicima odraslih osoba.[3]
Reference[уреди | уреди извор]
- ^ Zhao Z, Lee CC, Baldini A, Caskey CT (1995). „A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1”. Genomics. 27 (2): 370—3. PMID 7558010. doi:10.1006/geno.1995.1060.
- ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (1998). „Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7”. Biochem Biophys Res Commun. 252 (1): 117—22. PMID 9813155. doi:10.1006/bbrc.1998.9607.
- ^ а б „Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)”.
Literatura[уреди | уреди извор]
- Wang Y; Macke JP; Abella BS; et al. (1996). „A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.”. J. Biol. Chem. 271 (8): 4468—76. PMID 8626800. doi:10.1074/jbc.271.8.4468.
- Finch PW; He X; Kelley MJ; et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770—5. PMC 21233
. PMID 9192640. doi:10.1073/pnas.94.13.6770. - Tanaka S; Akiyoshi T; Mori M; et al. (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164—9. PMC 21479 . PMID 9707618. doi:10.1073/pnas.95.17.10164.
- Hering H, Sheng M (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.”. FEBS Lett. 521 (1–3): 185—9. PMID 12067714. doi:10.1016/S0014-5793(02)02831-4.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Oishi I; Suzuki H; Onishi N; et al. (2004). „The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway”. Genes Cells. 8 (7): 645—54. PMID 12839624. doi:10.1046/j.1365-2443.2003.00662.x.
- Omoto S; Hayashi T; Kitahara K; et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81—90. PMID 15370539. doi:10.1080/13816810490514270.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Vidi još[уреди | уреди извор]
Spoljašnje veze[уреди | уреди извор]
- „Frizzled Receptors: FZD2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.