Oreksinski receptor 1
| Hipokretinski (oreksinski) receptor 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | HCRTR1; OX1R | ||||||||||
| Vanjski ID | OMIM: 602392 MGI: 2385650 HomoloGene: 37492 IUPHAR: OX1 GeneCards: HCRTR1 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 3061 | 230777 | |||||||||
| Ensembl | ENSG00000121764 | ENSMUSG00000028778 | |||||||||
| UniProt | O43613 | Q0VDP5 | |||||||||
| RefSeq (mRNA) | NM_001525 | XM_983697 | |||||||||
| RefSeq (protein) | NP_001516 | XP_988791 | |||||||||
| Lokacija (UCSC) |
Chr 1: 31.86 - 31.87 Mb |
Chr 4: 129.63 - 129.64 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Oreksinski receptor tip 1 (OX1R, OX1, ili hipokretinski receptor tip 1), je protein koji je kod ljudi kodiran HCRTR1 genom.[1]
Funkcija[уреди | уреди извор]
OX1 je G-protein spregnuti receptor koji je izražen u hipotalamusu i učestvuje u regulaciji ishrane. OX1 selektivno vezuje neuropeptid oreksin-A. On je 64% identičan sa OX2.[1]
Ligandi[уреди | уреди извор]
Agonisti[уреди | уреди извор]
Antagonisti[уреди | уреди извор]
- Almoreksant - neselektivni OX1/2 antagonist
- SB-334,867 - selektivni OX1 antagonist
- SB-408,124 - selektivni OX1 antagonist
- SB-649,868 - neselektivni OX1/2 antagonist
Vidi još[уреди | уреди извор]
Literatura[уреди | уреди извор]
Dodatna literatura[уреди | уреди извор]
- Flier JS, Maratos-Flier E (1998). „Obesity and the hypothalamus: novel peptides for new pathways.”. Cell. 92 (4): 437—40. PMID 9491885. doi:10.1016/S0092-8674(00)80937-X.
- Willie JT, Chemelli RM, Sinton CM, Yanagisawa M (2001). „To eat or to sleep? Orexin in the regulation of feeding and wakefulness.”. Annu. Rev. Neurosci. 24: 429—58. PMID 11283317. doi:10.1146/annurev.neuro.24.1.429.
- Hungs M, Mignot E (2001). „Hypocretin/orexin, sleep and narcolepsy.”. Bioessays. 23 (5): 397—408. PMID 11340621. doi:10.1002/bies.1058.
- de Lecea L; Kilduff TS; Peyron C; et al. (1998). „The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.”. Proc. Natl. Acad. Sci. U.S.A. 95 (1): 322—7. PMC 18213
. PMID 9419374. doi:10.1073/pnas.95.1.322. - Sakurai T; Amemiya A; Ishii M; et al. (1998). „Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.” (PDF). Cell. 92 (4): 573—85. PMID 9491897. doi:10.1016/S0092-8674(00)80949-6. Архивирано из оригинала (PDF) 11. 07. 2011. г. Приступљено 22. 04. 2011.
- Sakurai T; Amemiya A; Ishii M; et al. (1998). „Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.”. Cell. 92 (5): 697. PMID 9527442. doi:10.1016/S0092-8674(02)09256-5.
- Peyron C; Faraco J; Rogers W; et al. (2000). „A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.”. Nat. Med. 6 (9): 991—7. PMID 10973318. doi:10.1038/79690.
- Blanco M; López M; GarcIa-Caballero T; et al. (2001). „Cellular localization of orexin receptors in human pituitary.”. J. Clin. Endocrinol. Metab. 86 (7): 3444—7. PMID 11443222. doi:10.1210/jc.86.7.3444.
- Olafsdóttir BR; Rye DB; Scammell TE; et al. (2002). „Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.”. Neurology. 57 (10): 1896—9. PMID 11723285.
- Wieland HA; Söll RM; Doods HN; et al. (2002). „The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor.”. Eur. J. Biochem. 269 (4): 1128—35. PMID 11856342. doi:10.1046/j.0014-2956.2001.02739.x.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Hilairet S; Bouaboula M; Carrière D; et al. (2003). „Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716.”. J. Biol. Chem. 278 (26): 23731—7. PMID 12690115. doi:10.1074/jbc.M212369200.
- Karteris E, Chen J, Randeva HS (2004). „Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system.”. J. Clin. Endocrinol. Metab. 89 (4): 1957—62. PMID 15070969. doi:10.1210/jc.2003-031778.
- Holmqvist T; Johansson L; Ostman M; et al. (2005). „OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms.”. J. Biol. Chem. 280 (8): 6570—9. PMID 15611118. doi:10.1074/jbc.M407397200.
- Spinazzi R; Rucinski M; Neri G; et al. (2005). „Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells.”. J. Clin. Endocrinol. Metab. 90 (6): 3544—9. PMID 15797953. doi:10.1210/jc.2004-2385.
- Meerabux J; Iwayama Y; Sakurai T; et al. (2005). „Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects.”. Biol. Psychiatry. 58 (5): 401—7. PMID 15978554. doi:10.1016/j.biopsych.2005.04.015.
- Ziolkowska A; Spinazzi R; Albertin G; et al. (2006). „Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor.”. J. Steroid Biochem. Mol. Biol. 96 (5): 423—9. PMID 16157481. doi:10.1016/j.jsbmb.2005.05.003.
Spoljašnje veze[уреди | уреди извор]
- „Orexin Receptors: OX1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 06. 02. 2016. г.