Neurotenzinski receptor 1

Из Википедије, слободне енциклопедије
Neurotenzinski receptor 1
Identifikatori
Simboli NTSR1; NTR
Vanjski ID OMIM162651 MGI97386 HomoloGene68261 IUPHAR: NTS1 GeneCards: NTSR1 Gene
Pregled RNK izražavanja
PBB GE NTSR1 207360 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 4923 18216
Ensembl ENSG00000101188 ENSMUSG00000027568
UniProt P30989 Q9QZQ2
RefSeq (mRNA) NM_002531 XM_989244
RefSeq (protein) NP_002522 XP_994338
Lokacija (UCSC) Chr 20:
60.81 - 60.86 Mb
Chr 2:
180.43 - 180.47 Mb
PubMed pretraga [1] [2]

Neurotenzinski receptor tip 1 je protein koji je kod ljudi kodiran NTSR1 genom.[1][2]

Neurotenzinski receptor 1 pripada velikoj familiji G-protein spregnutih receptora. NTSR1 posreduje višestruke funkcije neurotenzina, kao što je hipotenzija, hiperglicemija, hipotermija, antinocicepcija, i regulacija intestinalne motilnosti i sekrecije.[2]

Vidi još[уреди]

Literatura[уреди]

  1. ^ Laurent P, Clerc P, Mattei MG, Forgez P, Dumont X, Ferrara P, Caput D, Rostene W (Oct 1994). „Chromosomal localization of mouse and human neurotensin receptor genes“. Mamm Genome 5 (5): 303–6. DOI:10.1007/BF00389545. PMID 8075503. 
  2. ^ а б „Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)“. 

Dodatna literatura[уреди]

  • Vincent JP (1996). „Neurotensin receptors: binding properties, transduction pathways, and structure.“. Cell. Mol. Neurobiol. 15 (5): 501–12. DOI:10.1007/BF02071313. PMID 8719037. 
  • Vincent JP, Mazella J, Kitabgi P (1999). „Neurotensin and neurotensin receptors.“. Trends Pharmacol. Sci. 20 (7): 302–9. DOI:10.1016/S0165-6147(99)01357-7. PMID 10390649. 
  • Vita N, Laurent P, Lefort S, et al. (1993). „Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor.“. FEBS Lett. 317 (1-2): 139–42. DOI:10.1016/0014-5793(93)81509-X. PMID 8381365. 
  • Le F, Groshan K, Zeng XP, Richelson E (1997). „Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene.“. J. Biol. Chem. 272 (2): 1315–22. DOI:10.1074/jbc.272.2.1315. PMID 8995438. 
  • Boudin H, Pélaprat D, Rostène W, et al. (1998). „Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra.“. J. Neurosci. 18 (20): 8473–84. PMID 9763490. 
  • Ye X, Mehlen P, Rabizadeh S, et al. (1999). „TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.“. J. Biol. Chem. 274 (42): 30202–8. DOI:10.1074/jbc.274.42.30202. PMID 10514511. 
  • Wang L, Friess H, Zhu Z, et al. (2000). „Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease.“. Clin. Cancer Res. 6 (2): 566–71. PMID 10690540. 
  • Cusack B, Jansen K, McCormick DJ, et al. (2000). „A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist.“. Biochem. Pharmacol. 60 (6): 793–801. DOI:10.1016/S0006-2952(00)00409-3. PMID 10930533. 
  • Oakley RH, Laporte SA, Holt JA, et al. (2001). „Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.“. J. Biol. Chem. 276 (22): 19452–60. DOI:10.1074/jbc.M101450200. PMID 11279203. 
  • Leplatois P, Josse A, Guillemot M, et al. (2001). „Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor.“. Eur. J. Biochem. 268 (18): 4860–7. DOI:10.1046/j.0014-2956.2001.02407.x. PMID 11559354. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.“. Nature 414 (6866): 865–71. DOI:10.1038/414865a. PMID 11780052. 
  • Lundquist JT, Büllesbach EE, Golden PL, Dix TA (2002). „Topography of the neurotensin (NT)(8-9) binding site of human NT receptor-1 probed with NT(8-13) analogs.“. J. Pept. Res. 59 (2): 55–61. PMID 11906607. 
  • Somaï S, Gompel A, Rostène W, Forgez P (2002). „Neurotensin counteracts apoptosis in breast cancer cells.“. Biochem. Biophys. Res. Commun. 295 (2): 482–8. DOI:10.1016/S0006-291X(02)00703-9. PMID 12150975. 
  • Martin S, Navarro V, Vincent JP, Mazella J (2002). „Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line.“. Gastroenterology 123 (4): 1135–43. DOI:10.1053/gast.2002.36000. PMID 12360476. 
  • Toy-Miou-Leong M, Cortes CL, Beaudet A, et al. (2004). „Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation.“. J. Biol. Chem. 279 (13): 12636–46. DOI:10.1074/jbc.M303384200. PMID 14699144. 
  • Magazin M, Poszepczynska-Guigné E, Bagot M, et al. (2004). „Sezary syndrome cells unlike normal circulating T lymphocytes fail to migrate following engagement of NT1 receptor.“. J. Invest. Dermatol. 122 (1): 111–8. DOI:10.1046/j.0022-202X.2003.22131.x. PMID 14962098. 
  • Brun P, Mastrotto C, Beggiao E, et al. (2005). „Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation.“. Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G621–9. DOI:10.1152/ajpgi.00140.2004. PMID 15764810. 

Spoljašnje veze[уреди]