S1PR2

Sfingozin-1-fosfatni receptor 2
Sfingozin-1-fosfatni receptor 2
Dostupne strukture
	1ZTI
Identifikatori
Simboli	S1PR2; AGR16; EDG-5; EDG5; Gpcr13; H218; LPB2; S1P2
Vanjski ID	OMIM: 605111 MGI: 99569 HomoloGene: 3118 IUPHAR: S1P2 GeneCards: S1PR2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G-protein spregnutog receptora; • aktivnost faktora guanil-nukleotidne razmene; • vezivanje masne kiseline;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom;
Biološki proces	• metabolički proces energetske rezerve; • signalni put G-protein spregnutog receptora; • pozitivna regulacija kalcijumskog jonskog transporta u citozol;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	9294
Ensembl	ENSG00000175898
UniProt	O95136
RefSeq (mRNA)	NM_004230.3
RefSeq (protein)	NP_004221.3
Lokacija (UCSC)	Chr 19:; 10.33 - 10.34 Mb
PubMed pretraga	[1]

Sfingozin-1-fosfatni receptor 2 (S1PR2, S1P₂) je ljudski gen koji kodira G protein spregnuti receptor za koji se vezuje lipidni signalni molekul sfingozin 1-fosfat (S1P).^[1]

Funkcija[уреди | уреди извор]

Ova protein učestvuje u sfingozin 1-fosfatom indukovanoj ćelijskoj proliferaciji, opstanku, i transkripcionoj aktivaciji.^[1]

Reference[уреди | уреди извор]

^ ^а ^б „Entrez Gene: S1PR2, sphingosine-1-phosphate receptor 2”.

Literatura[уреди | уреди извор]

Spiegel S (2000). „Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.”. Ann. N. Y. Acad. Sci. 905: 54—60. PMID 10818441. doi:10.1111/j.1749-6632.2000.tb06537.x.
Takuwa Y (2002). „[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]”. Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496—502. PMID 11915348.
MacLennan AJ; Browe CS; Gaskin AA; et al. (1994). „Cloning and characterization of a putative G-protein coupled receptor potentially involved in development.”. Mol. Cell. Neurosci. 5 (3): 201—9. PMID 8087418. doi:10.1006/mcne.1994.1024.
Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). „Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.”. Biochem. Biophys. Res. Commun. 227 (2): 608—14. PMID 8878560. doi:10.1006/bbrc.1996.1553.
Van Brocklyn JR; Tu Z; Edsall LC; et al. (1999). „Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.”. J. Biol. Chem. 274 (8): 4626—32. PMID 9988698. doi:10.1074/jbc.274.8.4626.
Ancellin N, Hla T (1999). „Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.”. J. Biol. Chem. 274 (27): 18997—9002. PMID 10383399. doi:10.1074/jbc.274.27.18997.
Windh RT; Lee MJ; Hla T; et al. (1999). „Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.”. J. Biol. Chem. 274 (39): 27351—8. PMID 10488065. doi:10.1074/jbc.274.39.27351.
An S, Zheng Y, Bleu T (2000). „Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.”. J. Biol. Chem. 275 (1): 288—96. PMID 10617617. doi:10.1074/jbc.275.1.288.
Himmel HM; Meyer Zu Heringdorf D; Graf E; et al. (2000). „Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes.”. Mol. Pharmacol. 58 (2): 449—54. PMID 10908314.
Hla T (2001). „Sphingosine 1-phosphate receptors.”. 64 (1-4): 135—142. PMID 11331101.
Mazurais D; Robert P; Gout B; et al. (2002). „Cell type-specific localization of human cardiac S1P receptors.”. J. Histochem. Cytochem. 50 (5): 661—70. PMID 11967277.
Osada M; Yatomi Y; Ohmori T; et al. (2003). „Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist.”. Biochem. Biophys. Res. Commun. 299 (3): 483—7. PMID 12445827. doi:10.1016/S0006-291X(02)02671-2.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Vogler R; Sauer B; Kim DS; et al. (2003). „Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.”. J. Invest. Dermatol. 120 (4): 693—700. PMID 12648236. doi:10.1046/j.1523-1747.2003.12096.x.
Kaneider NC; Lindner J; Feistritzer C; et al. (2005). „The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.”. Faseb J. 18 (11): 1309—11. PMID 15208267. doi:10.1096/fj.03-1050fje.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Sanchez T; Thangada S; Wu MT; et al. (2005). „PTEN as an effector in the signaling of antimigratory G protein-coupled receptor.”. Proc. Natl. Acad. Sci. U.S.A. 102 (12): 4312—7. PMID 15764699. doi:10.1073/pnas.0409784102.
Sanchez T; Skoura A; Wu MT; et al. (2007). „Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN.”. Arterioscler. Thromb. Vasc. Biol. 27 (6): 1312—8. PMID 17431187. doi:10.1161/ATVBAHA.107.143735.

Vidi još[уреди | уреди извор]

Lizofosfolipidni receptor

Spoljašnje veze[уреди | уреди извор]

„Lysophospholipid Receptors: S₁P₂”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
Lysophospholipid+receptors на US National Library of Medicine Medical Subject Headings (MeSH)

[entrez-1] а ^б „Entrez Gene: S1PR2, sphingosine-1-phosphate receptor 2”.

[1]