Receptor paratiroidnog hormona 1

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Receptor paratiroidnog hormona 1

Prikaz baziran na 1BL1
Dostupne strukture
1BL1, 3C4M, 3H3G, 3L2J
Identifikatori
Simboli PTH1R; PFE; PTHR; PTHR1
Vanjski ID OMIM168468 MGI97801 HomoloGene267 IUPHAR: PTH1 GeneCards: PTH1R Gene
Pregled RNK izražavanja
PBB GE PTHR1 205911 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5745 19228
Ensembl ENSG00000160801 ENSMUSG00000032492
UniProt Q03431 P41593
RefSeq (mRNA) NM_000316.2 NM_001083935.1
RefSeq (protein) NP_000307.1 NP_001077404.1
Lokacija (UCSC) Chr 3:
46.92 - 46.95 Mb
Chr 9:
110.62 - 110.65 Mb
PubMed pretraga [1] [2]

Receptor paratiroidnog hormona 1 je protein koji je kod ljudi kodiran PTH1R genom. PTH1R deluje kao receptor za paratiroidni hormon (PTH) i za paratiroidnom hormonu srodan protein (PTHrP, ili PTHLH).

Funkcija[уреди]

Ovaj „klasični“ PTH receptor je izražen u visokim nivoima u kostima i bubrezima. On reguliše homeostazu jona kalcijuma putem aktivacije adenilat ciklaze i fosfolipaze C.[1][2] U kostima, on je izražen na površini osteoblasta. Kad je receptor aktiviran putem vezivanja PTH, osteoblasti izražavaju RANKL (receptorski aktivator za nuklearni faktor κB ligand), koji se vezuje za RANK (Receptorski aktivator za nuklearni faktor kB) na osteoklastima. Time se osteoklasti aktiviraju da povećaju brzinu resorpcije.

Mehanizam[уреди]

On je član sekretinske familije G protein spregnutih receptora. Aktivnost ovog receptora je poredovana Gs tipom G proteina koji aktiviraju adenilil ciklazu. Osim toga, oni mogu da aktiviraju fosfatidilinozitol-kalcijumski sistem sekundarnih glasnika.

Interakcije[уреди]

Receptor paratiroidnog hormona 1 formira interakcije sa regulatornim kofaktorom 2 natrijum-vodonične razmene[3] i regulatorom 1 natrijum-vodoničnog antiportera 3.[3]

Reference[уреди]

  1. ^ Mannstadt M, Jüppner H, Gardella TJ (1999). „Receptors for PTH and PTHrP: their biological importance and functional properties“. Am. J. Physiol. 277 (5 Pt 2): F665–75. PMID 10564229. 
  2. ^ Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). „G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells“. Mol. Endocrinol. 10 (5): 566–74. DOI:10.1210/me.10.5.566. PMID 8732687. 
  3. ^ а б Mahon, Matthew J; Donowitz Mark, Yun C Chris, Segre Gino V (Jun. 2002). „Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling“. Nature (England) 417 (6891): 858–61. DOI:10.1038/nature00816. ISSN 0028-0836. PMID 12075354. 

Literatura[уреди]

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