Melatoninski receptor 1B — разлика између измена

С Википедије, слободне енциклопедије
Интерактиван преглед историје
← Старија изменаНовија измена →
Садржај обрисан Садржај додат
ВизуелноВикитекст
Ред 4: Ред 4:
==Funkcija==
==Funkcija==
MT<sub>2</sub> [[protein]] je jedan od dve forme receptora sa visokim afinitetom za [[melatonin]], primarni hormon [[Epifiza|epifize]]. On je [[integralni membranski protein]] koji je [[G protein spregnuti receptor]], 7-[[transmembranski receptor]]. On je prisutan prvenstveno u retini i [[mozak|mozgu]]. Smatra se da on učestvuje u [[Светла фаза фотосинтезе|od svetla zavisnim funkcijama]] u [[retina|retini]] i da posreduje neurobiološke efekte melatonina.<ref name="entrez"/>
MT<sub>2</sub> [[protein]] je jedan od dve forme receptora sa visokim afinitetom za [[melatonin]], primarni hormon [[Epifiza|epifize]]. On je [[integralni membranski protein]] koji je [[G protein spregnuti receptor]], 7-[[transmembranski receptor]]. On je prisutan prvenstveno u retini i [[mozak|mozgu]]. Smatra se da on učestvuje u [[Светла фаза фотосинтезе|od svetla zavisnim funkcijama]] u [[retina|retini]] i da posreduje neurobiološke efekte melatonina.<ref name="entrez"/>

== Klinički značaj ==
Nekoliko studija je identifikovalo da su mutacije -{MTNR1B}- receptora vezane za povišeni prosečne nivoe [[krvni šećer|krvnog šećera]], i za oko 20 procenata povišen rizik razvoja [[Дијабетес|tip 2 dijabetesa]].<ref name="SN">{{cite web | url = http://www.sciencedaily.com/releases/2008/06/080609085957.htm | title = Gene That Regulates Glucose Levels And Increases Risk For Diabetes Identified | author = | authorlink = | coauthors = | date = 2008-06-28 | format = | work = | publisher = ScienceDaily | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2009-01-18}}; {{cite web | url = http://www.sciencedaily.com/releases/2008/12/081207133817.htm | title = Body Clock Linked To Diabetes And High Blood Sugar In New Genome-wide Study | author = | authorlink = | coauthors = | date = 2008-12-08 | format = | work = | publisher = ScienceDaily | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2009-01-18}}; {{cite web | url = http://www.sciencedaily.com/releases/2009/01/090116073601.htm | title = Is There A Relationship Between Sleep-wake Rhythm And Diabetes? A New Gene Variant Influences Fasting Glucose Levels Via The Melatonin Metabolism | author = | authorlink = | coauthors = | date = 2009-01-16 | format = | work = | publisher = ScienceDaily | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2009-01-18}}</ref><ref name="Nat_Genet_2009">{{cite journal | author = Prokopenko I, Langenberg C, Florez JC, ''et al.'' | title = Variants in MTNR1B influence fasting glucose levels | journal = Nat. Genet. | volume = 41 | issue = 1 | pages = 77–81 | year = 2009 | month = January | pmid = 19060907 | doi = 10.1038/ng.290 | url = | pmc = 2682768 }}; {{cite journal | author = Lyssenko V, Nagorny CL, Erdos MR, ''et al.'' | title = Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion | journal = Nat. Genet. | volume = 41 | issue = 1 | pages = 82–8 | year = 2009 | month = January | pmid = 19060908 | doi = 10.1038/ng.288 | url = }}; {{cite journal | author = Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, ''et al.'' | title = A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk | journal = Nat. Genet. | volume = 41 | issue = 1 | pages = 89–94 | year = 2009 | month = January | pmid = 19060909 | doi = 10.1038/ng.277 | url = }}</ref><ref name="pmid19088850">{{cite journal | author = Staiger H, Machicao F, Schäfer SA, ''et al.'' | title = Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function | journal = PLoS ONE | volume = 3 | issue = 12 | pages = e3962 | year = 2008 | pmid = 19088850 | pmc = 2597741 | doi = 10.1371/journal.pone.0003962 | url = | editor1-last = Maedler | editor1-first = Kathrin }}</ref> -{MTNR1B}- [[iRNK]] je izražena u ljudskim [[Лангерхансова острвца|Langerhansovim ostrvcima]], i [[imunocitohemija]] potvrđuje da je prvenstveno lociran u [[Бета ћелије|beta ćelija]]ma.<ref name="Nat_Genet_2009" />


==References==
==References==

Верзија на датум 24. јул 2012. у 15:35

Melatoninski receptor 1B
Identifikatori
Simboli MTNR1B; FGQTL2; MEL-1B-R; MT2
Vanjski ID OMIM: 600804 MGI: 2181726 HomoloGene: 4350 IUPHAR: MT2 GeneCards: MTNR1B Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 4544 244701
Ensembl ENSG00000134640 ENSMUSG00000050901
UniProt P49286 Q3SXF8
RefSeq (mRNA) NM_005959.3 NM_145712.2
RefSeq (protein) NP_005950.1 NP_663758.2
Lokacija (UCSC) Chr 11:
92.7 - 92.72 Mb		 Chr 9:
15.67 - 15.68 Mb
PubMed pretraga [1] [2]

Melatoninski receptor 1B (MTNR1B) je protein koji je kod ljudi kodiran MTNR1B genom.[1][2]

Funkcija

MT2 protein je jedan od dve forme receptora sa visokim afinitetom za melatonin, primarni hormon epifize. On je integralni membranski protein koji je G protein spregnuti receptor, 7-transmembranski receptor. On je prisutan prvenstveno u retini i mozgu. Smatra se da on učestvuje u od svetla zavisnim funkcijama u retini i da posreduje neurobiološke efekte melatonina.[1]

Klinički značaj

Nekoliko studija je identifikovalo da su mutacije MTNR1B receptora vezane za povišeni prosečne nivoe krvnog šećera, i za oko 20 procenata povišen rizik razvoja tip 2 dijabetesa.[3][4][5] MTNR1B iRNK je izražena u ljudskim Langerhansovim ostrvcima, i imunocitohemija potvrđuje da je prvenstveno lociran u beta ćelijama.[4]

References

  1. ^ а б „Entrez Gene: MTNR1B melatonin receptor 1B”. 
  2. ^ Reppert SM, Godson C, Mahle CD, Weaver DR, Slaugenhaupt SA, Gusella JF (1995). „Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor”. Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8734—8. PMC 41041 Слободан приступ. PMID 7568007. doi:10.1073/pnas.92.19.8734.  Непознати параметар |month= игнорисан (помоћ)
  3. ^ „Gene That Regulates Glucose Levels And Increases Risk For Diabetes Identified”. ScienceDaily. 2008-06-28. Приступљено 2009-01-18. ; „Body Clock Linked To Diabetes And High Blood Sugar In New Genome-wide Study”. ScienceDaily. 2008-12-08. Приступљено 2009-01-18. ; „Is There A Relationship Between Sleep-wake Rhythm And Diabetes? A New Gene Variant Influences Fasting Glucose Levels Via The Melatonin Metabolism”. ScienceDaily. 2009-01-16. Приступљено 2009-01-18. 
  4. ^ а б Prokopenko I, Langenberg C, Florez JC; et al. (2009). „Variants in MTNR1B influence fasting glucose levels”. Nat. Genet. 41 (1): 77—81. PMC 2682768 Слободан приступ. PMID 19060907. doi:10.1038/ng.290.  Непознати параметар |month= игнорисан (помоћ); Lyssenko V, Nagorny CL, Erdos MR; et al. (2009). „Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion”. Nat. Genet. 41 (1): 82—8. PMID 19060908. doi:10.1038/ng.288.  Непознати параметар |month= игнорисан (помоћ); Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C; et al. (2009). „A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk”. Nat. Genet. 41 (1): 89—94. PMID 19060909. doi:10.1038/ng.277.  Непознати параметар |month= игнорисан (помоћ)
  5. ^ Staiger H, Machicao F, Schäfer SA; et al. (2008). Maedler, Kathrin, ур. „Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function”. PLoS ONE. 3 (12): e3962. PMC 2597741 Слободан приступ. PMID 19088850. doi:10.1371/journal.pone.0003962. 

Literatura

  • Brzezinski A; Brzezinski, Amnon (1997). „Melatonin in humans”. N. Engl. J. Med. 336 (3): 186—95. PMID 8988899. doi:10.1056/NEJM199701163360306. 
  • Reppert SM, Godson C, Mahle CD; et al. (1995). „Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor”. Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8734—8. PMC 41041 Слободан приступ. PMID 7568007. doi:10.1073/pnas.92.19.8734. 
  • Reppert SM, Weaver DR, Ebisawa T; et al. (1996). „Cloning of a melatonin-related receptor from human pituitary”. FEBS Lett. 386 (2–3): 219—24. PMID 8647286. doi:10.1016/0014-5793(96)00437-1. 
  • Niles LP, Wang J, Shen L; et al. (2000). „Melatonin receptor mRNA expression in human granulosa cells”. Mol. Cell. Endocrinol. 156 (1–2): 107—10. PMID 10612428. doi:10.1016/S0303-7207(99)00135-5. 
  • Ebisawa T, Uchiyama M, Kajimura N; et al. (2000). „Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls”. Neurosci. Lett. 280 (1): 29—32. PMID 10696804. doi:10.1016/S0304-3940(99)00981-7. 
  • Roy D, Angelini NL, Fujieda H; et al. (2001). „Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin”. Endocrinology. 142 (11): 4711—20. PMID 11606436. doi:10.1210/en.142.11.4711. 
  • Ayoub MA, Couturier C, Lucas-Meunier E; et al. (2002). „Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer”. J. Biol. Chem. 277 (24): 21522—8. PMID 11940583. doi:10.1074/jbc.M200729200. 
  • Yuan L, Collins AR, Dai J; et al. (2003). „MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells”. Mol. Cell. Endocrinol. 192 (1–2): 147—56. PMID 12088876. doi:10.1016/S0303-7207(02)00029-1. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Slominski A, Pisarchik A, Zbytek B; et al. (2003). „Functional activity of serotoninergic and melatoninergic systems expressed in the skin”. J. Cell. Physiol. 196 (1): 144—53. PMID 12767050. doi:10.1002/jcp.10287. 
  • Ayoub MA, Levoye A, Delagrange P, Jockers R (2004). „Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers”. Mol. Pharmacol. 66 (2): 312—21. PMID 15266022. doi:10.1124/mol.104.000398. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 Слободан приступ. PMID 15489334. doi:10.1101/gr.2596504. 
  • Mazna P, Berka K, Jelinkova I; et al. (2005). „Ligand binding to the human MT2 melatonin receptor: the role of residues in transmembrane domains 3, 6, and 7”. Biochem. Biophys. Res. Commun. 332 (3): 726—34. PMID 15913560. doi:10.1016/j.bbrc.2005.05.017. 
  • Ha E, Choe BK, Jung KH; et al. (2005). „Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean population”. J. Pineal Res. 39 (2): 201—5. PMID 16098099. doi:10.1111/j.1600-079X.2005.00237.x. 
  • Savaskan E, Jockers R, Ayoub M; et al. (2007). „The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease”. Current Alzheimer research. 4 (1): 47—51. PMID 17316165. doi:10.2174/156720507779939823. 
  • Suzuki S, Masui Y, Ohnuki M; et al. (2007). „Induction of metallothionein synthesis by cilostazol in mice and in human cultured neuronal cell lines”. Biol. Pharm. Bull. 30 (4): 791—4. PMID 17409522. doi:10.1248/bpb.30.791. 
  • Qiu XS, Tang NL, Yeung HY; et al. (2007). „Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis”. Spine. 32 (16): 1748—53. PMID 17632395. doi:10.1097/BRS.0b013e3180b9f0ff. 

Spoljašnje veze

Vidi još

Преузето из „https://sr.wikipedia.org/w/index.php?title=Melatoninski_receptor_1B&oldid=5756914”