Beklometazon dipropionat

S Vikipedije, slobodne enciklopedije
Beklometazon dipropionat
Klinički podaci
Prodajno imeAerobec, Aldecin, Anceron, Andion
Drugs.comdipropionate.html Monografija
Način primeneNazalno, respiratorno (inhalacija), topikalno
Farmakokinetički podaci
Poluvreme eliminacije2,8 h
IzlučivanjeFekalno
Identifikatori
CAS broj5534-09-8 ДаY
ATC kodA07EA07 (WHO), R03BA01
PubChemCID 21700
DrugBankDB00394 ДаY
ChemSpider20396 ДаY
KEGGC07813 ДаY
ChEBICHEBI:3002 ДаY
ChEMBLCHEMBL1200500 ДаY
Hemijski podaci
FormulaC28H37ClO7
Molarna masa521,042
  • [H][C@@]12C[C@H](C)[C@](OC(=O)CC)(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
  • InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1
  • Key:KUVIULQEHSCUHY-XYWKZLDCSA-N ДаY
Fizički podaci
Tačka topljenja117—120 °C (243—248 °F)

Beklometazon dipropionat koji je u prodaji pod imenom Qvar, između ostalih, kortikosteroidni je lek.[1] On je dostupan u inhalacionom obliku, kao kream, pilule, i nazalni sprej.[2] Inhalaciona forma se koristi u dugoročnom tretmanu astme.[1] Krem se može koristiti za lečenje dermatitisa i psorijaze.[3] Pilule se koriste u tretmanu ulcerativnog kolitisa.[4] Nazalni sprej se koristi za tretman alergijskog rinitisa i nazalnih polipa.[5]

Osobine[uredi | uredi izvor]

Beklometazon dipropionat je organsko jedinjenje, koje sadrži 28 atoma ugljenika i ima molekulsku masu od 521,042 Da.[6][7][8][9][10][11][12][13][14]

Osobina Vrednost
Broj akceptora vodonika 7
Broj donora vodonika 1
Broj rotacionih veza 8
Particioni koeficijent[15] (ALogP) 4,1
Rastvorljivost[16] (logS, log(mol/L)) -6,4
Polarna površina[17] (PSA, Å2) 107,0

Reference[uredi | uredi izvor]

  1. ^ а б „Beclomethasone Dipropionate”. The American Society of Health-System Pharmacists. Pristupljeno 2. 12. 2015. 
  2. ^ „List of products: BECLOMETASONE DIPROPIONATE”. MHRA. Pristupljeno 6. 12. 2015. 
  3. ^ „Beclometasone dipropionate 0.25 mg/g Cream” (PDF). MHRA. Pristupljeno 6. 12. 2015. 
  4. ^ „Clipper” (PDF). MHRA. Pristupljeno 6. 12. 2015. 
  5. ^ „Beclomethasone Dipropionate eent”. The American Society of Health-System Pharmacists. Pristupljeno 2. 12. 2015. 
  6. ^ Willey RF, Milne LJ, Crompton GK, Grant IW: Beclomethasone dipropionate aerosol and oropharyngeal candidiasis. Br J Dis Chest. 1976 Jan;70(1):32-8. PMID 1259918
  7. ^ Salzman GA, Pyszczynski DR: Oropharyngeal candidiasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler alone and with Aerochamber. J Allergy Clin Immunol. 1988 Feb;81(2):424-8. PMID 3339197
  8. ^ Fukushima C, Matsuse H, Tomari S, Obase Y, Miyazaki Y, Shimoda T, Kohno S: Oral candidiasis associated with inhaled corticosteroid use: comparison of fluticasone and beclomethasone. Ann Allergy Asthma Immunol. 2003 Jun;90(6):646-51. PMID 12839324
  9. ^ Astegiano M, Pagano N, Sapone N, Simondi D, Bertolusso L, Bresso F, Demarchi B, Pellicano R, Bonardi R, Marconi S, Rizzetto M: Efficacy and safety of oral beclomethasone dipropionate for ileal or ileal-right colon Crohn's disease of mild-to-moderate activity or in remission: Retrospective study. Biomed Pharmacother. 2007 Jul;61(6):370-6. Epub 2007 Mar 12. PMID 17399941
  10. ^ McDonald GB: Oral beclomethasone dipropionate: a topically active corticosteroid for the treatment of gastrointestinal graft-versus-host disease following allogeneic hematopoietic cell transplantation. Expert Opin Investig Drugs. 2007 Oct;16(10):1709-24. PMID 17922633
  11. ^ Hockenbery DM, Cruickshank S, Rodell TC, Gooley T, Schuening F, Rowley S, David D, Brunvand M, Berryman B, Abhyankar S, Bouvier M, McDonald GB: A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease. Blood. 2007 May 15;109(10):4557-63. Epub 2007 Jan 23. PMID 17244684
  12. ^ Castilla C, Perez-Simon JA, Sanchez-Guijo FM, Diez-Campelo M, Ocio E, Perez-Persona E, Lopez-Villar O, Vazquez L, Caballero D, San Miguel JF: Oral beclomethasone dipropionate for the treatment of gastrointestinal acute graft-versus-host disease (GVHD). Biol Blood Marrow Transplant. 2006 Sep;12(9):936-41. PMID 16920559
  13. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  14. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  15. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  16. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  17. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura[uredi | uredi izvor]

Spoljašnje veze[uredi | uredi izvor]


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