Zofenopril
 | |
| IUPAC ime | |
|---|---|
(2S,4S)-1-((S)-3-(benzoiltio)-2-metilpropanoil)-4-(feniltio)pirolidin-2-karboksilna kiselina | |
| Klinički podaci | |
| Drugs.com | Internacionalno ime leka |
| Način primene | Oralno |
| Identifikatori | |
| CAS broj | 81872-10-8  |
| ATC kod | C09AA15 (WHO) |
| PubChem | CID 92400 |
| ChemSpider | 83422 |
| UNII | 290ZY759PI |
| KEGG | D08688 |
| ChEMBL | CHEMBL331378 |
| Hemijski podaci | |
| Formula | C22H23NO4S2 |
| Molarna masa | 429,552 g/mol |
| |
| |
Zofenopril (Zofenoprilum) je inhbitor angiotenzin konvertujućeg enzima (ACE) sa kardioprotektivnim svojstvima, koji se koristi za tretman hipertenzije.[1]
U manjim kliničkim studijama je utvrđeno da je zofenopril znatno efektivniji od starijih antihipertenziva atenolola i enalaprila, i da uzrokuje manji broj nuspojava.[2][3]
Osobine[uredi | uredi izvor]
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 6 |
| Broj donora vodonika | 1 |
| Broj rotacionih veza | 8 |
| Particioni koeficijent[4] (ALogP) | 3,9 |
| Rastvorljivost[5] (logS, log(mol/L)) | -5,8 |
| Polarna površina[6] (PSA, Å2) | 125,3 |
Reference[uredi | uredi izvor]
- ^ Ambrosioni E (2007). „Defining the role of zofenopril in the management of hypertension and ischemic heart disorders”. Am J Cardiovasc Drugs. 7 (1): 17—24. PMID 17355163. doi:10.2165/00129784-200707010-00002.
- ^ Nilsson P (2007). „Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension”. Blood Press Suppl. 2: 25—30. PMID 18046976.
- ^ Mallion, JM (2007). „An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension”. Blood Press Suppl. 2: 13—8. PMID 18046974.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura[uredi | uredi izvor]
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze[uredi | uredi izvor]
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
