CCL17

Из Википедије, слободне енциклопедије
Hemokin (C-C motiv) ligand 17
PDB prikaz baziran na 1nr2.
Dostupne strukture
1nr2, 1nr4
Identifikatori
Simboli CCL17; A-152E5.3; ABCD-2; MGC138271; MGC138273; SCYA17; TARC
Vanjski ID OMIM601520 MGI1329039 HomoloGene2246 GeneCards: CCL17 Gene
Pregled RNK izražavanja
PBB GE CCL17 207900 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6361 20295
Ensembl ENSG00000102970 ENSMUSG00000031780
UniProt Q92583 n/a
RefSeq (mRNA) NM_002987 NM_011332
RefSeq (protein) NP_002978 NP_035462
Lokacija (UCSC) Chr 16:
56.01 - 56.01 Mb
Chr 8:
97.7 - 97.7 Mb
PubMed pretraga [1] [2]

CCL17, hemokin (C-C motiv) ligand 17, je mali citokin iz CC hemokin familije koji je takođe poznat kao timusom i activacijom regulisani hemokin (TARC). CCL17 je izražen konstitutivno u timusu, ali samo tranzijentno u fitohemaglutinin-stimulisanim perifernim krvnim mononuklearnim ćelijama.[1] Ovaj hemokin se specifično vezuje i indukuje hemotaksu u T ćelijama. On dejstvuje putem interakcija sa hemokin receptorom CCR4.[1][2] Gen za CCL17 je lociran na hromozomu 16 kod ljudi, zajedno sa hemokinima CCL22 i CX3CL1.[3][4][5]

Reference[уреди]

  1. 1,0 1,1 Imai T, Yoshida T, Baba M, Nishimura M, Kakizaki M, Yoshie O (1996). „Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector”. J. Biol. Chem. 271 (35): 21514—21. doi:10.1074/jbc.271.35.21514. PMID 8702936. 
  2. Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (1997). „The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4”. J. Biol. Chem. 272 (23): 15036—42. doi:10.1074/jbc.272.23.15036. PMID 9169480. 
  3. Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1997). „Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13”. Genomics 40 (1): 211—3. doi:10.1006/geno.1996.4552. PMID 9070951. 
  4. Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). „Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13”. Cytogenet. Cell Genet. 81 (1): 10—1. doi:10.1159/000015000. PMID 9691168. 
  5. Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

Literatura[уреди]

  • Saeki H, Tamaki K (2006). „Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases.”. J. Dermatol. Sci. 43 (2): 75—84. doi:10.1016/j.jdermsci.2006.06.002. PMID 16859899. 
  • Imai T, Yoshida T, Baba M; et al. (1996). „Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector.”. J. Biol. Chem. 271 (35): 21514—21. doi:10.1074/jbc.271.35.21514. PMID 8702936. 
  • Nomiyama H, Imai T, Kusuda J; et al. (1997). „Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13.”. Genomics 40 (1): 211—3. doi:10.1006/geno.1996.4552. PMID 9070951. 
  • Imai T, Baba M, Nishimura M; et al. (1997). „The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.”. J. Biol. Chem. 272 (23): 15036—42. doi:10.1074/jbc.272.23.15036. PMID 9169480. 
  • Imai T, Chantry D, Raport CJ; et al. (1998). „Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.”. J. Biol. Chem. 273 (3): 1764—8. doi:10.1074/jbc.273.3.1764. PMID 9430724. 
  • Bernardini G, Hedrick J, Sozzani S; et al. (1998). „Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor.”. Eur. J. Immunol. 28 (2): 582—8. doi:10.1002/(SICI)1521-4141(199802)28:02<582::AID-IMMU582>3.0.CO;2-A. PMID 9521068. 
  • Nomiyama H, Imai T, Kusuda J; et al. (1998). „Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13.”. Cytogenet. Cell Genet. 81 (1): 10—1. doi:10.1159/000015000. PMID 9691168. 
  • Struyf S, Proost P, Sozzani S; et al. (1998). „Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor.”. J. Immunol. 161 (6): 2672—5. PMID 9743322. 
  • Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). „Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.”. Genomics 60 (3): 295—308. doi:10.1006/geno.1999.5927. PMID 10493829. 
  • Garlisi CG, Xiao H, Tian F; et al. (1999). „The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8.”. Eur. J. Immunol. 29 (10): 3210—5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID 10540332. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). „Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.”. Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491—6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. 
  • Ghia P, Transidico P, Veiga JP; et al. (2001). „Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells.”. Blood 98 (3): 533—40. doi:10.1182/blood.V98.3.533. PMID 11468146. 
  • Morita A, Kikuoka S, Horikawa T; et al. (2002). „Evaluation of human thymus and activation-regulated chemokine concentrations in blood using a new sandwich ELISA based on monoclonal antibodies.”. Clin. Chim. Acta 322 (1-2): 67—75. doi:10.1016/S0009-8981(02)00131-6. PMID 12104083. 
  • Basu S, Schaefer TM, Ghosh M; et al. (2003). „Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines.”. Cytokine 18 (3): 140—8. doi:10.1006/cyto.2002.0875. PMID 12126650. 
  • D'Ambrosio D, Albanesi C, Lang R; et al. (2002). „Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion.”. J. Immunol. 169 (5): 2303—12. PMID 12193695. 
  • Matsumoto N, Mukae H, Nakamura-Uchiyama F; et al. (2002). „Elevated levels of thymus and activation-regulated chemokine (TARC) in pleural effusion samples from patients infested with Paragonimus westermani.”. Clin. Exp. Immunol. 130 (2): 314—8. doi:10.1046/j.1365-2249.2002.01985.x. PMC 1906524. PMID 12390321. 
  • Zheng X, Nakamura K, Tojo M; et al. (2003). „TGF-beta1-mediated regulation of thymus and activation-regulated chemokine (TARC/CCL17) synthesis and secretion by HaCaT cells co-stimulated with TNF-alpha and IFN-gamma.”. J. Dermatol. Sci. 30 (2): 154—60. doi:10.1016/S0923-1811(02)00071-3. PMID 12413771. 
  • Kakinuma T, Nakamura K, Wakugawa M; et al. (2003). „IL-4, but not IL-13, modulates TARC (thymus and activation-regulated chemokine)/CCL17 and IP-10 (interferon-induced protein of 10kDA)/CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line.”. Cytokine 20 (1): 1—6. doi:10.1006/cyto.2002.1965. PMID 12441140. 
  • Uchida T, Suto H, Ra C; et al. (2003). „Preferential expression of T(h)2-type chemokine and its receptor in atopic dermatitis.”. Int. Immunol. 14 (12): 1431—8. doi:10.1093/intimm/dxf109. PMID 12456591. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 


Spoljašnje veze[уреди]