CX3CL1

Из Википедије, слободне енциклопедије
Hemokin (C-X3-C motiv) ligand 1
Dostupne strukture
1b2t, 1f2l
Identifikatori
Simboli CX3CL1; NTN; ABCD-3; C3Xkine; CXC3; CXC3C; NTT; SCYD1; fractalkine; neurotactin
Vanjski ID OMIM601880 MGI1097153 HomoloGene2251 GeneCards: CX3CL1 Gene
Pregled RNK izražavanja
PBB GE CX3CL1 823 at tn.png
PBB GE CX3CL1 203687 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6376 20312
Ensembl ENSG00000006210 ENSMUSG00000031778
UniProt P78423 Q8C9Y1
RefSeq (mRNA) NM_002996 NM_009142
RefSeq (protein) NP_002987 NP_033168
Lokacija (UCSC) Chr 16:
55.96 - 55.98 Mb
Chr 8:
97.66 - 97.67 Mb
PubMed pretraga [1] [2]

CX3CL1, hemokin (C-X3-C motiv) ligand 1, je veliki citokin protein sa 373 aminokiseline. On sadrži više domena. Ovo je jedini član CX3C hemokin familije. On je poznat pod imenima fraktalkin (kod ljudi) i neurotaktin (kod miševa).[1][2] Polipeptidna struktura CXC3L1 se razlikuje od tipične strukture drugih hemokina. Na primer, razmak između karakterističnih N-terminalnih cisteina je različit; postoje tri aminokiseline između inicijalnog para cisteina u CX3CL1, koji se ne javljaju u CC hemokinima. Postoji samo jedna aminokiselina u tom segmentu CXC hemokina. CX3CL1 se proizvodi kao dugački protein (sa 373 aminokiseline kod ljudi) sa produženim poput mucina stablom i hemokin domenom na vrhu. Mucinu-slično stablo dozvoljava mu da se veže na površinu pojedinih ćelija. Rastvorna (90 kD) verzija ovog hemokina takođe je bila primećena. Rastvorni CX3CL1 je potencijalni hemoatraktant T ćelija i monocita, dok hemokin vezan za ćeliju promoviše snažnu adheziju leukocita na aktivirane endotelne ćelije, gde je on prvenstveno izražen.[2] CX3CL1 izaziva svoje adhezivne i migratorne funkcije putem interakcija sa hemokin receptorom CX3CR1.[3] Njegov gene je lociran na ljudskom hromozom 16 zajedno sa nekim CC hemokinima poznatim kao CCL17 i CCL22.[2][4][5]

Reference[уреди]

  1. Pan; et al. (1997). „Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation”. Nature. 387: 611—617. 
  2. 2,0 2,1 2,2 „A new class of membrane-bound chemokine with a CX3C motif”. Nature. 385: 640—644. 1997. 
  3. Imai; et al. (1997). „Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion”. Cell. 91: 521—530. 
  4. Nomiyama; et al. (1998). „Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13. Cytogenet”. Cell Genet. 81: 10—11. 
  5. Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

Literatura[уреди]

  • Umehara H, Bloom ET, Okazaki T; et al. (2004). „Fractalkine in vascular biology: from basic research to clinical disease.”. Arterioscler. Thromb. Vasc. Biol. 24 (1): 34—40. doi:10.1161/01.ATV.0000095360.62479.1F. PMID 12969992. 
  • Umehara H, Tanaka M, Sawaki T; et al. (2006). „Fractalkine in rheumatoid arthritis and allied conditions.”. Mod Rheumatol. 16 (3): 124—30. doi:10.1007/s10165-006-0471-9. PMID 16767549. 
  • Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene. 138 (1-2): 171—4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Bazan JF, Bacon KB, Hardiman G; et al. (1997). „A new class of membrane-bound chemokine with a CX3C motif.”. Nature. 385 (6617): 640—4. doi:10.1038/385640a0. PMID 9024663. 
  • Pan Y, Lloyd C, Zhou H; et al. (1997). „Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation.”. Nature. 387 (6633): 611—7. doi:10.1038/42491. PMID 9177350. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.”. Gene. 200 (1-2): 149—56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Imai T, Hieshima K, Haskell C; et al. (1997). „Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion.”. Cell. 91 (4): 521—30. doi:10.1016/S0092-8674(00)80438-9. PMID 9390561. 
  • Nomiyama H, Imai T, Kusuda J; et al. (1998). „Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13.”. Cytogenet. Cell Genet. 81 (1): 10—1. doi:10.1159/000015000. PMID 9691168. 
  • Combadiere C, Salzwedel K, Smith ED; et al. (1998). „Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1.”. J. Biol. Chem. 273 (37): 23799—804. doi:10.1074/jbc.273.37.23799. PMID 9726990. 
  • Meucci O, Fatatis A, Simen AA; et al. (1998). „Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity.”. Proc. Natl. Acad. Sci. U.S.A. 95 (24): 14500—5. doi:10.1073/pnas.95.24.14500. PMC 24402слободно за читање. PMID 9826729. 
  • Mizoue LS, Bazan JF, Johnson EC, Handel TM (1999). „Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1.”. Biochemistry. 38 (5): 1402—14. doi:10.1021/bi9820614. PMID 9931005. 
  • Papadopoulos EJ, Sassetti C, Saeki H; et al. (1999). „Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation.”. Eur. J. Immunol. 29 (8): 2551—9. doi:10.1002/(SICI)1521-4141(199908)29:08<2551::AID-IMMU2551>3.0.CO;2-T. PMID 10458770. 
  • Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). „Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.”. Genomics. 60 (3): 295—308. doi:10.1006/geno.1999.5927. PMID 10493829. 
  • Tong N, Perry SW, Zhang Q; et al. (2000). „Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system.”. J. Immunol. 164 (3): 1333—9. PMID 10640747. 
  • Faure S, Meyer L, Costagliola D; et al. (2000). „Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1.”. Science. 287 (5461): 2274—7. doi:10.1126/science.287.5461.2274. PMID 10731151. 
  • Hoover DM, Mizoue LS, Handel TM, Lubkowski J (2000). „The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement.”. J. Biol. Chem. 275 (30): 23187—93. doi:10.1074/jbc.M002584200. PMID 10770945. 
  • Meucci O, Fatatis A, Simen AA, Miller RJ (2000). „Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival.”. Proc. Natl. Acad. Sci. U.S.A. 97 (14): 8075—80. doi:10.1073/pnas.090017497. PMC 16672слободно за читање. PMID 10869418. 
  • Papadopoulos EJ, Fitzhugh DJ, Tkaczyk C; et al. (2000). „Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin.”. Eur. J. Immunol. 30 (8): 2355—61. doi:10.1002/1521-4141(2000)30:8<2355::AID-IMMU2355>3.0.CO;2-#. PMID 10940926. 
  • Lucas AD, Chadwick N, Warren BF; et al. (2001). „The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo.”. Am. J. Pathol. 158 (3): 855—66. PMC 1850344слободно за читање. PMID 11238035. 
  • Garton KJ, Gough PJ, Blobel CP; et al. (2001). „Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).”. J. Biol. Chem. 276 (41): 37993—8001. doi:10.1074/jbc.M106434200. PMID 11495925.