CXCL11

Из Википедије, слободне енциклопедије
Иди на навигацију Иди на претрагу
Hemokin (C-X-C motiv) ligand 11
PDB prikaz baziran na 1rjt.
Dostupne strukture
1rjt
Identifikatori
Simboli CXCL11; H174; I-TAC; IP-9; IP9; MGC102770; SCYB11; SCYB9B; b-R1
Vanjski ID OMIM604852 MGI1860203 HomoloGene3944 GeneCards: CXCL11 Gene
Pregled RNK izražavanja
PBB GE CXCL11 210163 at tn.png
PBB GE CXCL11 211122 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6373 56066
Ensembl ENSG00000169248 n/a
UniProt O14625 n/a
RefSeq (mRNA) NM_005409 NM_019494
RefSeq (protein) NP_005400 NP_062367
Lokacija (UCSC) Chr 4:
77.17 - 77.18 Mb
n/a
PubMed pretraga [1] [2]

CXCL11, hemokin (C-X-C motiv) ligand 11,[1] je mali citokin i CXC hemokin familije. Om se takođe zove Interferon-inducirani T-ćelijski alfa hemoatraktant (I-TAC) i Interferon-gama-inducirani protein 9 (IP-9). On je visoko izražen u perifernim krvnim leukocitima, pankreasu i jetri, u umerenim nivoima u timus, slezini i plućima, i u niskim nivoima u tankim crevima, posteljici i prostati.[2] Ekspresiju CXCL11 gena je u velikoj meri indukuju IFN-γ i IFN-β, i u maloj meri doprinosi IFN-α.[3] Ovaj hemokin dejstvuje putem interakcija sa hemokin receptorom CXCR3 na površini njegovih ciljnih ćelija, sa većim afinitetom nego drugi ligandi za ovaj receptor, CXCL9 i CXCL10.[2][4] CXCL11 je hemotaksan za aktivirane T ćelije. Njegov gen je lociran na ljudskom hromozomu 4 zajedno sa mnogim drugim članovima CXC hemokin familije.[5][6][7]

Reference[уреди]

  1. ^ „Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11”. 
  2. 2,0 2,1 Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K (1998). „Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3”. J. Exp. Med. 187 (12): 2009—21. PMC 2212354Слободан приступ. PMID 9625760. doi:10.1084/jem.187.12.2009. 
  3. ^ Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM (1996). „Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha”. J. Biol. Chem. 271 (37): 22878—84. PMID 8798467. doi:10.1074/jbc.271.37.22878. 
  4. ^ Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (1999). „Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)”. J. Invest. Dermatol. 112 (5): 716—22. PMID 10233762. doi:10.1046/j.1523-1747.1999.00581.x. 
  5. ^ Erdel M, Laich A, Utermann G, Werner ER, Werner-Felmayer G (1998). „The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)”. Cytogenet. Cell Genet. 81 (3-4): 271—2. PMID 9730616. doi:10.1159/000015043. 
  6. ^ O'Donovan N, Galvin M, Morgan JG (1999). „Physical mapping of the CXC chemokine locus on human chromosome 4”. Cytogenet. Cell Genet. 84 (1-2): 39—42. PMID 10343098. doi:10.1159/000015209. 
  7. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

Literatura[уреди]

  • Rani MR; Foster GR; Leung S; et al. (1996). „Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha.”. J. Biol. Chem. 271 (37): 22878—84. PMID 8798467. doi:10.1074/jbc.271.37.22878. 
  • Jacobs KA; Collins-Racie LA; Colbert M; et al. (1997). „A genetic selection for isolating cDNAs encoding secreted proteins.”. Gene. 198 (1-2): 289—96. PMID 9370294. doi:10.1016/S0378-1119(97)00330-2. 
  • Cole KE; Strick CA; Paradis TJ; et al. (1998). „Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3.”. J. Exp. Med. 187 (12): 2009—21. PMC 2212354Слободан приступ. PMID 9625760. doi:10.1084/jem.187.12.2009. 
  • Erdel M; Laich A; Utermann G; et al. (1998). „The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10).”. Cytogenet. Cell Genet. 81 (3-4): 271—2. PMID 9730616. doi:10.1159/000015043. 
  • Luo Y; Kim R; Gabuzda D; et al. (1999). „The CXC-chemokine, H174: expression in the central nervous system.”. J. Neurovirol. 4 (6): 575—85. PMID 10065899. doi:10.3109/13550289809114224. 
  • Tensen CP; Flier J; Van Der Raaij-Helmer EM; et al. (1999). „Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).”. J. Invest. Dermatol. 112 (5): 716—22. PMID 10233762. doi:10.1046/j.1523-1747.1999.00581.x. 
  • Laich A, Meyer M, Werner ER, Werner-Felmayer G (1999). „Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1).”. J. Interferon Cytokine Res. 19 (5): 505—13. PMID 10386863. doi:10.1089/107999099313956. 
  • Tensen CP; Flier J; Rampersad SS; et al. (1999). „Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene.”. Biochim. Biophys. Acta. 1446 (1-2): 167—72. PMID 10395932. 
  • Loetscher P; Pellegrino A; Gong JH; et al. (2001). „The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3.”. J. Biol. Chem. 276 (5): 2986—91. PMID 11110785. doi:10.1074/jbc.M005652200. 
  • Lambeir AM; Proost P; Durinx C; et al. (2001). „Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family.”. J. Biol. Chem. 276 (32): 29839—45. PMID 11390394. doi:10.1074/jbc.M103106200. 
  • Hensbergen PJ; van der Raaij-Helmer EM; Dijkman R; et al. (2001). „Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity.”. Eur. J. Biochem. 268 (18): 4992—9. PMID 11559369. doi:10.1046/j.0014-2956.2001.02433.x. 
  • Mohan K, Ding Z, Hanly J, Issekutz TB (2002). „IFN-gamma-inducible T cell alpha chemoattractant is a potent stimulator of normal human blood T lymphocyte transendothelial migration: differential regulation by IFN-gamma and TNF-alpha.”. J. Immunol. 168 (12): 6420—8. PMID 12055261. 
  • Basu S; Schaefer TM; Ghosh M; et al. (2003). „Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines.”. Cytokine. 18 (3): 140—8. PMID 12126650. doi:10.1006/cyto.2002.0875. 
  • Salmaggi A; Gelati M; Dufour A; et al. (2003). „Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis.”. J. Interferon Cytokine Res. 22 (6): 631—40. PMID 12162873. doi:10.1089/10799900260100114. 
  • Rani MR; Hibbert L; Sizemore N; et al. (2002). „Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene.”. J. Biol. Chem. 277 (41): 38456—61. PMID 12169689. doi:10.1074/jbc.M203204200. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Kao J; Kobashigawa J; Fishbein MC; et al. (2003). „Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease.”. Circulation. 107 (15): 1958—61. PMID 12695288. doi:10.1161/01.CIR.0000069270.16498.75. 
  • Satish L, Yager D, Wells A (2003). „Glu-Leu-Arg-negative CXC chemokine interferon gamma inducible protein-9 as a mediator of epidermal-dermal communication during wound repair.”. J. Invest. Dermatol. 120 (6): 1110—7. PMID 12787142. doi:10.1046/j.1523-1747.2003.12230.x. 
  • Klunker S; Trautmann A; Akdis M; et al. (2003). „A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis.”. J. Immunol. 171 (2): 1078—84. PMID 12847282. 
  • Xanthou G, Duchesnes CE, Williams TJ, Pease JE (2003). „CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.”. Eur. J. Immunol. 33 (8): 2241—50. PMID 12884299. doi:10.1002/eji.200323787. 

Spoljašnje veze[уреди]