AMG-3

Из Википедије, слободне енциклопедије
AMG-3
AMG-3.png
IUPAC ime
(6aR,10aR)-3-(2-heksil-1,3-ditiolan-2-il)-6,6,9-trimetil-6a,7,10,10a-tetrahidrobenzo[c]hromen-1-ol
Identifikatori
PubChem CID 10002952
ChemSpider 8178532 ДаY
ChEMBL CHEMBL476325 ДаY
Hemijski podaci
Formula C25H36O2S2
Molarna masa 432,681 g/mol
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AMG-3 je analgetik koji je kanabinoidni agonist. On je derivat Δ8THC koji je supstituisan sa ditiolanskom grupom u 3-poziciji bočnog lanca.[1] AMG-3 je potentan agonist CB1 i CB2 receptora sa Ki od 0,32 nM na CB1 i 0,52 nM na CB2.[2][3]

Reference[уреди]

  1. Mavromoustakos T, Theodoropoulou E, Zervou M, Kourouli T, Papahatjis D. Structure elucidation and conformational properties of synthetic cannabinoids (-)-2-(6a,7,10,10a-tetrahydro-6,6,9-trimethyl-1-hydroxy-6H-dibenzo[b,d]pyranyl)-2-hexyl-1,3-dithiolane and its methylated analog. Journal of Pharmaceutical and Biomedical Analysis. 1999 Jan;18(6):947-56. PMID 9925329
  2. Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219
  3. Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753
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