CP 47,497

Из Википедије, слободне енциклопедије
CP 47,497
(IUPAC) ime
2-[(1R,3S)-3-hidroksicikloheksil]- 5-(2-metiloktan-2-il)fenol
Klinički podaci
Identifikatori
CAS broj 70434-82-1
70434-92-3 (C8 homolog)
ATC kod nije dodeljen
PubChem[1][2] 125835
ChEMBL[3] CHEMBL163701 YesY
Hemijski podaci
Formula C21H34O2 
Mol. masa 318,492 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Ilegalan u Nemačkoj i Francuskoj, Klasa B (UK)

CP 47,497 ili (C7)-CP 47,497 je agonist kanabinoidnog receptora, koji je razvilo preduzeće Pfizer tokom 1980-tih.[4] Ovaj materijal ima analgetsko dejstvo i koristi se u naučnim istraživanjima. Ono je potentan CB1 agonist sa Kd vrednošću od 2,1 nM.[5][6][7]

Vidi još[уреди]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  4. ^ Weissman A, Milne GM, Melvin LS Jr. Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol. Journal of Pharmacology and Experimental Therapeutics. 1982 Nov;223(2):516-23. PMID 6290642
  5. ^ Shim JY, Welsh WJ, Howlett AC. Homology model of the CB1 cannabinoid receptor: sites critical for nonclassical cannabinoid agonist interaction. Biopolymers. 2003;71(2):169-89. PMID 12767117
  6. ^ Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168. Springer. ISBN 3-540-22565-X
  7. ^ Little PJ, et al. Pharmacology and stereoselectivity of structurally novel cannabinoids in mice. Journal of Pharmacology and Experimental Therapeutics 1988; 247:1046–1051.

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