Limfotoksin alfa

Limfotoksin alfa (TNF superfamilija, član 1)
Limfotoksin alfa (TNF superfamilija, član 1)
	PDB prikaz baziran na 1tnr.
Dostupne strukture
	1tnr
Identifikatori
Simboli	LTA; LT; TNFB; TNFSF1
Vanjski ID	OMIM: 153440 MGI: 104797 HomoloGene: 497 GeneCards: LTA Gene
Ontologija gena
Molekularna funkcija	• aktivnost endopeptidaze cisteinskog tipa; • citokinska aktivnost; • vezivanje za receptor faktora nekroze tumora;
Celularna komponenta	• ekstracelularni prostor; • membrana;
Biološki proces	• proteoliza; • indukcija apoptoze; • imunski odgovor; • humoralni imunski odgovor; • prenos signala; • interćelijska signalizacija; • razvoj limfnih čvorova;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	4049
Ensembl	ENSG00000204496
UniProt	P01374
RefSeq (mRNA)	NM_000595
RefSeq (protein)	NP_000586
Lokacija (UCSC)	Chr 6:; 31.65 - 31.65 Mb
PubMed pretraga	[1]

Limfotoksin-alfa je protein koji je kod ljudi kodiran LTA genom.^[1]^[2]

Limfotoksin alfa, član familije faktora nekroze tumora, je citokin koga proizvode limfociti. LTA je visoko induktivan i izlučiv. On postoji kao homotrimerni molekul. LTA formira heterotrimere sa limfotoksinom-beta, čime se limfotoksin-alfa učvršćuje za ćelijsku površinu. LTA posreduje širok niz inflamatornih, imunostimulatornih, i antiviralnih odgovora. LTA takođe učestvuje u formaciji sekundarnih limfoidnih organa tokom razvoja, i ima ulogu u apoptozi.^[3]

Interakcije[уреди | уреди извор]

Za limfotoksin alfa je bilo pokazano da interaguje sa LTB.^[4]^[5]^[6]

Vidi još[уреди | уреди извор]

Limfotoksin

Reference[уреди | уреди извор]

^ Nedwin GE, Naylor SL, Sakaguchi AY, Smith D, Jarrett-Nedwin J, Pennica D, Goeddel DV, Gray PW (1985). „Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization”. Nucleic Acids Res. 13 (17): 6361—73. PMC 321958 . PMID 2995927. doi:10.1093/nar/13.17.6361.
^ Aggarwal BB, Eessalu TE, Hass PE (1986). „Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon”. Nature. 318 (6047): 665—7. PMID 3001529.
^ „Entrez Gene: LTA lymphotoxin alpha (TNF superfamily, member 1)”.
^ Williams-Abbott, L; Walter B N; et al. (1997). „The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand”. J. Biol. Chem. UNITED STATES. 272 (31): 19451—6. ISSN 0021-9258. PMID 9235946. doi:10.1074/jbc.272.31.19451.
^ Browning, J L; Sizing I D; et al. (1997). „Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes”. J. Immunol. UNITED STATES. 159 (7): 3288—98. ISSN 0022-1767. PMID 9317127.
^ Browning, J L; Dougas I; et al. (1995). „Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors”. J. Immunol. UNITED STATES. 154 (1): 33—46. ISSN 0022-1767. PMID 7995952.

Literatura[уреди | уреди извор]

Körner H, Sedgwick JD (1997). „Tumour necrosis factor and lymphotoxin: molecular aspects and role in tissue-specific autoimmunity.”. Immunol. Cell Biol. 74 (5): 465—72. PMID 8912010. doi:10.1038/icb.1996.77.
Wang Q (2005). „Molecular genetics of coronary artery disease.”. Curr. Opin. Cardiol. 20 (3): 182—8. PMC 1579824 . PMID 15861005. doi:10.1097/01.hco.0000160373.77190.f1.
Copeland KF (2006). „Modulation of HIV-1 transcription by cytokines and chemokines.”. Mini reviews in medicinal chemistry. 5 (12): 1093—101. PMID 16375755. doi:10.2174/138955705774933383.
Elewaut D, Ware CF (2007). „The unconventional role of LT alpha beta in T cell differentiation.”. Trends Immunol. 28 (4): 169—75. PMID 17336158. doi:10.1016/j.it.2007.02.005.

[pmid2995927-1] Nedwin GE, Naylor SL, Sakaguchi AY, Smith D, Jarrett-Nedwin J, Pennica D, Goeddel DV, Gray PW (1985). „Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization”. Nucleic Acids Res. 13 (17): 6361—73. PMC 321958 . PMID 2995927. doi:10.1093/nar/13.17.6361.

[pmid3001529-2] Aggarwal BB, Eessalu TE, Hass PE (1986). „Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon”. Nature. 318 (6047): 665—7. PMID 3001529.

[3] „Entrez Gene: LTA lymphotoxin alpha (TNF superfamily, member 1)”.

[pmid9235946-4] Williams-Abbott, L; Walter B N; et al. (1997). „The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand”. J. Biol. Chem. UNITED STATES. 272 (31): 19451—6. ISSN 0021-9258. PMID 9235946. doi:10.1074/jbc.272.31.19451.

[pmid9317127-5] Browning, J L; Sizing I D; et al. (1997). „Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes”. J. Immunol. UNITED STATES. 159 (7): 3288—98. ISSN 0022-1767. PMID 9317127.

[pmid7995952-6] Browning, J L; Dougas I; et al. (1995). „Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors”. J. Immunol. UNITED STATES. 154 (1): 33—46. ISSN 0022-1767. PMID 7995952.

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