Metil aminolevulinat

Metil aminolevulinat
IUPAC ime
	metil 5-amino-4-okso-pentanoat
Klinički podaci
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Identifikatori
CAS broj	33320-16-0
ATC kod	L01XD03 (WHO)
PubChem	CID 16052023
DrugBank	DB00992
ChemSpider	13180320
ChEMBL	CHEMBL1096562
Hemijski podaci
Formula	C6H11NO3
Molarna masa	145,156 g/mol
	SMILES O=C(CC(N)C(=O)OC)C; ;
	InChI InChI=1S/C6H11NO3/c1-4(8)3-5(7)6(9)10-2/h5H,3,7H2,1-2H3 ; Key:FLQHIIVXMKXKFT-UHFFFAOYSA-N ;

Metil aminolevulinat (MAL, Metviks) je prolek koji se metaboliše do protoporfirina IX. On se koristi u fotodinamičkoj terapiji. Metviks krema se primenjuje topikalno.

Odobrenja i indikacije

Metil aminolevulinat je odobren u mnogim zemljama za tretman nemelanomnog raka kože.^[1] Ovaj lek je odobren u Novom Zelandu za tretmant karcinoma bazalnih ćelija.^[2]

On ima izvesne prednosti u odnosu na Levulan.^[3]

Reference

^ "New 5 Year Metvix-PDT Data Demonstrate Long-Term Efficacy & Reliability For NM Skin Cancer Treatment" 2006^{[мртва веза]}
^ "Methyl aminolevulinate photodynamic therapy (MAL PDT)"
^ Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy Photochemistry and Photobiology, Sep/Oct 2009 by O'Connor, Aisling E, Gallagher, William M, Byrne, Annette T

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[1] "New 5 Year Metvix-PDT Data Demonstrate Long-Term Efficacy & Reliability For NM Skin Cancer Treatment" 2006^{[мртва веза]}

[2] "Methyl aminolevulinate photodynamic therapy (MAL PDT)"

[3] Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy Photochemistry and Photobiology, Sep/Oct 2009 by O'Connor, Aisling E, Gallagher, William M, Byrne, Annette T

[1]

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