Dimenhidrinat

Dimenhidrinat
Klinički podaci
Prodajno ime	Amosyt, Anautine, Andramine, Antemin
Drugs.com	Monografija
Način primene	Oralno, intramaskularno, intravenozno
Farmakokinetički podaci
Poluvreme eliminacije	1 - 4 h
Identifikatori
CAS broj	523-87-5
ATC kod	R06AA02 (WHO)
PubChem	CID 441281
DrugBank	DB00985
ChemSpider	390044
ChEBI	CHEBI:4604
ChEMBL	CHEMBL1200406
Hemijski podaci
Formula	C24H28ClN5O3
Molarna masa	469,964
	SMILES CN1C2=C([N-]C(Cl)=N2)C(=O)N(C)C1=O.C[NH+](C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1; ;
	InChI InChI=1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10,13) ; Key:DKHVTDUUNTVKOW-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	2.045 °C (3.713 °F)

Dimenhidrinat je organsko jedinjenje, koje sadrži 24 atoma ugljenika i ima molekulsku masu od 469,964 Da.^[1]^[2]^[3]^[4]^[5]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	5
Broj donora vodonika	1
Broj rotacionih veza	6
Particioni koeficijent^[6] (ALogP)	2,5
Rastvorljivost^[7] (logS, log(mol/L))	-7,8
Polarna površina^[8] (PSA, Å²)	81,3

Reference

^ Takeda N, Morita M, Hasegawa S, Horii A, Kubo T, Matsunaga T: Neuropharmacology of motion sickness and emesis. A review. Acta Otolaryngol Suppl. Takeda, N.; Morita, M.; Hasegawa, S.; Horii, A.; Kubo, T.; Matsunaga, T. (1993). . „Neuropharmacology of motion sickness and emesis. A review”. Acta Oto-Laryngologica. Supplementum. 501: 10—5. PMID 8447218. doi:10.3109/00016489309126205.
^ Halpert AG, Olmstead MC, Beninger RJ: Mechanisms and abuse liability of the anti-histamine dimenhydrinate. Neurosci Biobehav Rev. Halpert, A. G.; Olmstead, M. C.; Beninger, R. J. (јануар 2002). . „Mechanisms and abuse liability of the anti-histamine dimenhydrinate”. Neuroscience and Biobehavioral Reviews. 26 (1): 61—7. PMID 11835984. doi:10.1016/s0149-7634(01)00038-0.
^ Jaju BP, Wang SC: Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: a search for the locus of their antimotion sickness action. Jaju, B. P.; Wang, S. C. (март 1971). . „Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: A search for the locus of their antimotion sickness action”. The Journal of Pharmacology and Experimental Therapeutics. 176 (3): 718—724. PMID 4329456. doi:10.1016/S0022-3565(25)28835-8. .
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). . „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). . „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Dimenhydrinate

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Takeda N, Morita M, Hasegawa S, Horii A, Kubo T, Matsunaga T: Neuropharmacology of motion sickness and emesis. A review. Acta Otolaryngol Suppl. Takeda, N.; Morita, M.; Hasegawa, S.; Horii, A.; Kubo, T.; Matsunaga, T. (1993). . „Neuropharmacology of motion sickness and emesis. A review”. Acta Oto-Laryngologica. Supplementum. 501: 10—5. PMID 8447218. doi:10.3109/00016489309126205.

[2] Halpert AG, Olmstead MC, Beninger RJ: Mechanisms and abuse liability of the anti-histamine dimenhydrinate. Neurosci Biobehav Rev. Halpert, A. G.; Olmstead, M. C.; Beninger, R. J. (јануар 2002). . „Mechanisms and abuse liability of the anti-histamine dimenhydrinate”. Neuroscience and Biobehavioral Reviews. 26 (1): 61—7. PMID 11835984. doi:10.1016/s0149-7634(01)00038-0.

[3] Jaju BP, Wang SC: Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: a search for the locus of their antimotion sickness action. Jaju, B. P.; Wang, S. C. (март 1971). . „Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: A search for the locus of their antimotion sickness action”. The Journal of Pharmacology and Experimental Therapeutics. 176 (3): 718—724. PMID 4329456. doi:10.1016/S0022-3565(25)28835-8. .

[4] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[5] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[6] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[7] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). . „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[8] Ertl, P.; Rohde, B.; Selzer, P. (2000). . „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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