Midazolam

Midazolam
Klinički podaci
Prodajno ime	Dormicum, Versed
Drugs.com	Monografija
Način primene	Parenteralno, oralno
Farmakokinetički podaci
Poluvreme eliminacije	1,8 - 6,4 h
Izlučivanje	Renalno
Identifikatori
CAS broj	59467-70-8
ATC kod	N05CD08 (WHO)
PubChem	CID 4192
IUPHAR/BPS	3342
DrugBank	DB00683
ChemSpider	4047
KEGG	C07524
ChEMBL	CHEMBL655
Hemijski podaci
Formula	C18H13ClFN3
Molarna masa	325,767
	SMILES CC1=NC=C2CN=C(C3=CC=CC=C3F)C3=C(C=CC(Cl)=C3)N12; ;
	InChI InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3 ; Key:DDLIGBOFAVUZHB-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	159 °C (318 °F)

Midazolam je organsko jedinjenje, koje sadrži 18 atoma ugljenika i ima molekulsku masu od 325,767 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]

Osobine[уреди | уреди извор]

Osobina	Vrednost
Broj akceptora vodonika	2
Broj donora vodonika	0
Broj rotacionih veza	1
Particioni koeficijent^[9] (ALogP)	4,1
Rastvorljivost^[10] (logS, log(mol/L))	-6,4
Polarna površina^[11] (PSA, Å²)	30,2

Reference[уреди | уреди извор]

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^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Lee Y, Wang JJ, Yang YL, Chen A, Lai HY. Midazolam vs ondansetron for preventing postoperative nausea and vomiting: A randomised controlled trial. Anaesthesia. 2007;62:18–22.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.