Alfred G. Gilman

Alfred G. Gilman
Gilman 1994.
Lični podaci
Datum rođenja	(1941-07-01)1. jul 1941.
Mesto rođenja	Nju Hejven, SAD
Datum smrti	23. decembar 2015.(2015-12-23) (74 god.)
Mesto smrti	Dalas, SAD
Obrazovanje	Univerzitet Jejl, Univerzitet Virdžinije, Case Western Reserve University
Naučni rad
Polje	Farmakologija
Institucija	Case Western Reserve University
Poznat po	G-protein
Nagrade	Nobelova nagrada za fiziologiju ili medicinu (1994)

Alfred Gudman Gilman (engl. Alfred Goodman Gilman; Nju Hejven, 1. jul 1941 — Dalas, 23. decembar 2015) bio je američki biohemičar i farmakolog, koji se proslavio otkrićem G-proteina i ulogom proteina u prenosu signala u ćelijama. Za ovo otkriće dodeljena mu je Nobelova nagrada za fiziologiju ili medicinu, zajedno sa Martinom Rodbelom 1994.

Galerija

1994. Poster dobitnika Nobelove nagrade za Fiziologiju i medicinu

Bibliografija

• Seeds, N. W.; Gilman, A. G. (1971). „Norepinephrine stinulated increase of cyclic AMP levels in developing mouse brain cell cultures”. Science. 174 (4006): 292. Bibcode:1971Sci...174..292S. PMID 4330303. S2CID 98674465. doi:10.1126/science.174.4006.292. .
• Gilman, A. G.; Nirenberg, M. (1971-12-10). „Regulation of adenosine 3',5'-cyclic monophosphate metabolism in cultured neuroblastoma cells”. Nature. 234 (5328): 356—8. Bibcode:1971Natur.234..356G. PMID 4332686. S2CID 4169292. doi:10.1038/234356a0. .
• Secrist Ja, 3rd; Barrio, J. R.; Leonard, N. J.; Villar-Palasi, C.; Gilman, A. G. (1972-07-21). „Fluorescent modification of adenosine 3',5'-monophosphate: Spectroscopic properties and activity in enzyme systems”. Science. 177 (45): 279—80. Bibcode:1972Sci...177..279S. PMID 4339302. S2CID 23752942. doi:10.1126/science.177.4045.279. .
• Sternweis, P. C.; Northup, J. K.; Smigel, M. D.; Gilman, A. G. (1981-11-25). „The regulatory component of adenylate cyclase. Purification and properties”. The Journal of Biological Chemistry. 256 (22): 11517—26. PMID 6271754. doi:10.1016/S0021-9258(19)68431-0 . .
• Hanski, E.; Sternweis, P. C.; Northup, J. K.; Dromerick, A. W.; Gilman, A. G. (1981-12-25). „The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein”. The Journal of Biological Chemistry. 256 (24): 12911—9. PMID 6273414. doi:10.1016/S0021-9258(18)42983-3 . .
• Schleifer, L. S.; Kahn, R. A.; Hanski, E.; Northup, J. K.; Sternweis, P. C.; Gilman, A. G. (1982-01-10). „Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase”. The Journal of Biological Chemistry. 257 (1): 20—3. PMID 6273425. doi:10.1016/S0021-9258(19)68316-X . .
• Northup, J. K.; Smigel, M. D.; Gilman, A. G. (1982-10-10). „The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding”. The Journal of Biological Chemistry. 257 (19): 11416—23. PMID 6288684. doi:10.1016/S0021-9258(18)33775-X . .
• Manning, D. R.; Gilman, A. G. (1983-06-10). „The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins”. The Journal of Biological Chemistry. 258 (11): 7059—63. PMID 6304074. doi:10.1016/S0021-9258(18)32332-9 . .
• Northup, J. K.; Sternweis, P. C.; Gilman, A. G. (1983-09-25). „The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (Beta) subunit”. The Journal of Biological Chemistry. 258 (18): 11361—8. PMID 6309843. doi:10.1016/S0021-9258(17)44426-7 . .
• Northup, J. K.; Smigel, M. D.; Sternweis, P. C.; Gilman, A. G. (1983-09-25). „The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (Alpha) subunit”. The Journal of Biological Chemistry. 258 (18): 11369—76. PMID 6309844. doi:10.1016/S0021-9258(17)44427-9 . .
• Hurley, J. B.; Simon, M. I.; Teplow, D. B.; Robishaw, J. D.; Gilman, A. G. (1984-11-16). „Homologies between signal transducing G proteins and ras gene products”. Science. 226 (4676): 860—2. Bibcode:1984Sci...226..860H. PMID 6436980. doi:10.1126/science.6436980. .
• Gilman, A. G. (mart 1984). „G proteins and dual control of adenylate cyclase”. Cell. 36 (3): 577—9. PMID 6321035. S2CID 36861537. doi:10.1016/0092-8674(84)90336-2. CS1 održavanje: Format datuma (veza).
• Bokoch, G. M.; Gilman, A. G. (1984). „Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin”. Cell. 39 (2 Pt 1): 301—308. PMID 6094010. S2CID 10507727. doi:10.1016/0092-8674(84)90008-4. .
• Harris, B. A.; Robishaw, J. D.; Mumby, S. M.; Gilman, A. G. (1985-09-20). „Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase”. Science. 229 (4719): 1274—7. Bibcode:1985Sci...229.1274H. PMID 3839937. doi:10.1126/science.3839937. .
• Mattera, R.; Graziano, M. P.; Yatani, A.; Zhou, Z.; Graf, R.; Codina, J.; Birnbaumer, L.; Gilman, A. G.; Brown, A. M. (1989-02-10). „Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels”. Science. 243 (4892): 804—7. Bibcode:1989Sci...243..804M. PMID 2536957. doi:10.1126/science.2536957. .
• Krupinski, J.; Coussen, F.; Bakalyar, H. A.; Tang, W. J.; Feinstein, P. G.; Orth, K.; Slaughter, C.; Reed, R. R.; Gilman, A. G. (1989-06-30). „Adenylyl cyclase amino acid sequence: Possible channel- or transporter-like structure”. Science. 244 (4912): 1558—64. Bibcode:1989Sci...244.1558K. PMID 2472670. doi:10.1126/science.2472670. .
• Tang, W. J.; Gilman, A. G. (1991-12-06). „Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits”. Science. 254 (5037): 1500—3. Bibcode:1991Sci...254.1500T. PMID 1962211. doi:10.1126/science.1962211. .
• Taussig, R.; Iñiguez-Lluhi, J. A.; Gilman, A. G. (1993-07-09). „Inhibition of adenylyl cyclase by Gi alpha”. Science. 261 (5118): 218—21. Bibcode:1993Sci...261..218T. PMID 8327893. doi:10.1126/science.8327893. .
• Wickman, K. D.; Iñiguez-Lluhl, J. A.; Davenport, P. A.; Taussig, R.; Krapivinsky, G. B.; Linder, M. E.; Gilman, A. G.; Clapham, D. E. (1994-03-17). „Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel”. Nature. 368 (6468): 255—7. Bibcode:1994Natur.368..255W. PMID 8145826. S2CID 4367498. doi:10.1038/368255a0. .
• Coleman, D. E.; Berghuis, A. M.; Lee, E.; Linder, M. E.; Gilman, A. G.; Sprang, S. R. (1994). „Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis”. Science. 265 (5177): 1405—1412. Bibcode:1994Sci...265.1405C. PMID 8073283. doi:10.1126/science.8073283. .
• Tang, W. J.; Gilman, A. G. (1995-06-23). „Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin”. Science. 268 (5218): 1769—72. Bibcode:1995Sci...268.1769T. PMID 7792604. doi:10.1126/science.7792604. .
• Mixon, M. B.; Lee, E.; Coleman, D. E.; Berghuis, A. M.; Gilman, A. G.; Sprang, S. R. (1995-11-10). „Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis”. Science. 270 (5238): 954—60. Bibcode:1995Sci...270..954M. PMID 7481799. S2CID 86608235. doi:10.1126/science.270.5238.954. .
• Wall, M. A.; Coleman, D. E.; Lee, E.; Iñiguez-Lluhi, J. A.; Posner, B. A.; Gilman, A. G.; Sprang, S. R. (1995-12-15). „The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2”. Cell. 83 (6): 1047—58. PMID 8521505. S2CID 18993038. doi:10.1016/0092-8674(95)90220-1. .
• Berman, D. M.; Wilkie, T. M.; Gilman, A. G. (1996). „GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits”. Cell. 86 (3): 445—452. PMID 8756726. S2CID 12427406. doi:10.1016/s0092-8674(00)80117-8. .
• Sunahara, R. K.; Tesmer, J. J.; Gilman, A. G.; Sprang, S. R. (1997-12-12). „Crystal structure of the adenylyl cyclase activator Gsalpha”. Science. 278 (5345): 1943—7. Bibcode:1997Sci...278.1943S. PMID 9395396. doi:10.1126/science.278.5345.1943. .
• Tesmer, J. J.; Sunahara, R. K.; Gilman, A. G.; Sprang, S. R. (1997-12-12). „Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.”. Science. 278 (5345): 1907—16. Bibcode:1997Sci...278.1907T. PMID 9417641. doi:10.1126/science.278.5345.1907. .

Literatura

• Rasmussen, Søren G. F.; Devree, Brian T.; Zou, Yaozhong; Kruse, Andrew C.; Chung, Ka Young; Kobilka, Tong Sun; Thian, Foon Sun; Chae, Pil Seok; Pardon, Els; Calinski, Diane; Mathiesen, Jesper M.; Shah, Syed T. A.; Lyons, Joseph A.; Caffrey, Martin; Gellman, Samuel H.; Steyaert, Jan; Skiniotis, Georgios; Weis, William I.; Sunahara, Roger K.; Kobilka, Brian K. (2011). „Crystal structure of the β2 adrenergic receptor–Gs protein complex”. Nature. 477 (7366): 549—555. Bibcode:2011Natur.477..549R. PMC 3184188 . PMID 21772288. doi:10.1038/nature10361. 
• (jezik: engleski) Authors' summary on the structure (Science) (Pristupljeno 26 Nov. 2007)

Spoljašnje veze

• (jezik: engleski) Nobel Prize Autobiography
• (jezik: engleski) The Official Site of Louisa Gross Horwitz Prize
• (jezik: engleski) Alfred Gilman profile at NNDB