Oleuropein
| Oleuropein | |
|---|---|
 |
|
| IUPAC ime |
|
| Identifikacija | |
| CAS registarski broj | 32619-42-4  |
| PubHem | 5281544 |
| HemPauk | 4444876 |
| SMILES |
|
| InChI |
|
| Svojstva | |
| Molekulska formula | C25H32O13 |
| Molarna masa | 540,51 g/mol |
| Tačna masa | 540,1842898 u |
|
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala |
|
| Infobox references | |
Oleuropein je hemijsko jedinjenje pristno u maslinovom lišću. Ono se javlja zajedno sa blisko srodnim jedinjenjima kao što su 10-hidroksioleuropein, ligstrozid, i 10-hidroksiligstrozid. Sva ta jedinjenja su tirozolni estri elenolinske kiseline koja su dalje hidroksilovana i glikozilovana. On je jedan od glavnih prirodnih fenola prisutnih u arganskom ulju.[1] On je takođe prisutan u lišću kaline.
Oleuropein i njegov metabolit hidroksitirozol imaju moćno antioksidansno dejstvo in vivo i in vitro. Oleuropein je jedno od jedinjenja koja daju ekstra devičanskom maslinovom ulju njegov gorak, opor ukus. Preparati oleuropeina imaju više farmakoloških dejstava,[2][3] jedno od kojih je ojačavanje imunskog sistema. Ispitivanja na pacovima sugerišu da oleuropein pojačava termogenezu putem povišenaj sadržaja termogenina u smeđem adipoznom tkivu i sekreciju noradrenalina i adrenalina.[4]
Reference [уреди]
- ^ Phenols and Polyphenols from Argania spinosa. Z. Charrouf and D. Guillaume, American Journal of Food Technology, 2007, 2, pages 679-683, doi:10.3923/ajft.2007.679.683
- ^ Haris Omar, Syed (2010). „Oleuropein in Olive and its Pharmacological Effects“. Scientia Pharmaceutica 78 (2): 133–54. DOI:10.3797/scipharm.0912-18.
- ^ Sudjana, Aurelia N.; D’Orazio, Carla; Ryan, Vanessa; Rasool, Nooshin; Ng, Justin; Islam, Nabilah; Riley, Thomas V.; Hammer, Katherine A. (2009). „Antimicrobial activity of commercial Olea europaea (olive) leaf extract“. International Journal of Antimicrobial Agents 33 (5): 461–3. DOI:10.1016/j.ijantimicag.2008.10.026. PMID 19135874.
- ^ Oi-Kano, Yuriko; Kawada, Teruo; Watanabe, Tatsuo; Koyama, Fumihiro; Watanabe, Kenichi; Senbongi, Reijirou; Iwai, Kazuo (2008). „Oleuropein, a Phenolic Compound in Extra Virgin Olive Oil, Increases Uncoupling Protein 1 Content in Brown Adipose Tissue and Enhances Noradrenaline and Adrenaline Secretions in Rats“. Journal of Nutritional Science and Vitaminology 54 (5): 363–70. DOI:10.3177/jnsv.54.363. PMID 19001767.
Vidi još [уреди]
Literatura [уреди]
- Tripoli, Elisa; Giammanco, Marco; Tabacchi, Garden; Di Majo, Danila; Giammanco, Santo; La Guardia, Maurizio (2009). „The phenolic compounds of olive oil: Structure, biological activity and beneficial effects on human health“. Nutrition Research Reviews 18 (1): 98–112. DOI:10.1079/NRR200495. PMID 19079898.
- Walter Jr, WM; Fleming, HP; Etchells, JL (1973). „Preparation of antimicrobial compounds by hydrolysis of oleuropein from green olives“. Applied microbiology 26 (5): 773–6. PMC 379900. PMID 4762396.
- Andreadou, Ioanna; Iliodromitis, Efstathios K.; Mikros, Emmanuel; Constantinou, Maria; Agalias, Apostolos; Magiatis, Prokopios; Skaltsounis, Alexios Leandros; Kamber, Elli et al. (2006). „The Olive Constituent Oleuropein Exhibits Anti-Ischemic, Antioxidative, and Hypolipidemic Effects in Anesthetized Rabbits“. The Journal of Nutrition 136 (8): 2213–9. PMID 16857843.
- Leehuang, S; Huang, P; Zhang, D; Lee, J; Bao, J; Sun, Y; Chang, Y; Zhang, J et al. (2007). „Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. Integrase inhibition“. Biochemical and Biophysical Research Communications 354 (4): 872–8. DOI:10.1016/j.bbrc.2007.01.071. PMC 2790717. PMID 17275783.
- Lee-Huang S, Huang P, Huang P (2004 July 11–16). „Anti-HIV activity of olive leaf extract and synergism with HAART“. Int Conf AIDS 15th. Bangkok.
|
||||||||
