Interleukin 11
Interleukin 11 | |||||||||||
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Identifikatori | |||||||||||
Simboli | IL11; AGIF; IL-11 | ||||||||||
Vanjski ID | OMIM: 147681 MGI: 107613 HomoloGene: 535 GeneCards: IL11 Gene | ||||||||||
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Pregled RNK izražavanja | |||||||||||
podaci | |||||||||||
Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 3589 | 16156 | |||||||||
Ensembl | ENSG00000095752 | ENSMUSG00000004371 | |||||||||
UniProt | P20809 | Q3V0U3 | |||||||||
Ref. Sekv. (iRNK) | NM_000641 | NM_008350 | |||||||||
Ref. Sekv. (protein) | NP_000632 | NP_032376 | |||||||||
Lokacija (UCSC) |
Chr 19: 60.57 - 60.57 Mb |
Chr 7: 4.38 - 4.38 Mb | |||||||||
PubMed pretraga | [1] | [2] |
Interleukin 11 (IL-11) je protein koji je kod ljudi kodiran IL11 genom.[1][2]
IL-11 je multifunkcionalni citokin koji je prvo izolovan 1990. godine iz kičmene moždine-izvedenih stromalnih ćelija. On je ključni regulator of više evenata hematopoeze, pogotovu stimulacije sazrevanja megakariocita.[3] On je isto poznat pod imenima inhibitorni faktor adipogeneze (AGIF)[4] i oprelvekin.
U poređenju sa drugim interleukinima, IL-11 je relativno slabo karakterisan.
Struktura[uredi | uredi izvor]
Ljudski IL-11 gen, koji sadrži 5 eksona i 4 introna, je lociran na hromozomu 19,[1] i kodira 23 kDa protein. IL-11 is je član IL-6 citokinske familije, koja je osobena po upotrebi zajedničkog koreceptora gp130. Signal specifičnost daje IL-11R alfa podjedinica.
Signalizacija[uredi | uredi izvor]
Prenos signala se inicira nakon IL-11 vezivanja za IL-11R alfa i gp130, što omogućava homodimerizaciju gp130 molekula. Ovo omogućava gp130-asociranoj JAK kinazi da se aktivira i da fosforiliše intracelularne tirozinove ostatke na gp130.[5][6]
Funkcija[uredi | uredi izvor]
Za IL-11 je bilo pokazano da poboljšava oporavak trombocita nakon hemoterapijom-uzrokovane trombocitopenije, inducira akutnu fazu proteina, modulira antigen-antitelo odziv, učestvuje u regulaciji proliferacije i diferencijacije koštanih ćelija, i možda može biti korišćen kao terapeutik za osteoporozu. IL-11 stimuliše rast određenih limfocita, i u modelu na glodarima, stimuliše povećanje kortikalne debljine i jačanje dugačkih kostiju. Pored toga što ima limfopoetske/hematopoetske i osteotrofske osobine, on funkcioniše u mnogim drugim tkivima, uključujući mozak, creva i testise.
Reference[uredi | uredi izvor]
- ^ a b McKinley D, Wu Q, Yang-Feng T, Yang YC (1992). „Genomic sequence and chromosomal location of human interleukin-11 gene (IL11)”. Genomics. 13 (3): 814—9. PMID 1386338. doi:10.1016/0888-7543(92)90158-O.
- ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
- ^ Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O'Hara RM, Leary AC, Sibley B, Clark SC, Williams DA (1990). „Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine”. Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7512—6. PMID 2145578. doi:10.1073/pnas.87.19.7512.
- ^ Kawashima I, Ohsumi J, Mita-Honjo K, Shimoda-Takano K, Ishikawa H, Sakakibara S, Miyadai K, Takiguchi Y (1991). „Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11”. FEBS Lett. 283 (2): 199—202. PMID 1828438. doi:10.1016/0014-5793(91)80587-S.
- ^ Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F (2003). „Principles of interleukin (IL)-6-type cytokine signalling and its regulation”. Biochem. J. 374 (Pt 1): 1—20. PMC 1223585 . PMID 12773095. doi:10.1042/BJ20030407.
- ^ Thomas J. Kindt; Richard A. Goldsby; Barbara Anne Osborne; Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1429202114.
Literatura[uredi | uredi izvor]
- Yang YC, Yin T (1993). „Interleukin-11 and its receptor.”. Biofactors. 4 (1): 15—21. PMID 1292471.
- Bhatia M, Davenport V, Cairo MS (2007). „The role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with solid tumors, lymphoma, acute myeloid leukemia and bone marrow failure syndromes.”. Leuk. Lymphoma. 48 (1): 9—15. PMID 17325843. doi:10.1080/10428190600909115.
- McKinley D, Wu Q, Yang-Feng T, Yang YC (1992). „Genomic sequence and chromosomal location of human interleukin-11 gene (IL11).”. Genomics. 13 (3): 814—9. PMID 1386338. doi:10.1016/0888-7543(92)90158-O.
- Kawashima, I.; J, Ohsumi; Mita-Honjo K (1991). „Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11.”. FEBS Lett. 283 (2): 199—202. PMID 1828438. doi:10.1016/0014-5793(91)80587-S.
- Paul, S. R.; F, Bennett; JA, Calvetti (1990). „Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.”. Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7512—6. PMID 2145578. doi:10.1073/pnas.87.19.7512.
- Wang XY, Fuhrer DK, Marshall MS, Yang YC (1996). „Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells.”. J. Biol. Chem. 270 (47): 27999—8002. PMID 7499280.
- Chérel, M.; M, Sorel; B, Lebeau (1995). „Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11.”. Blood. 86 (7): 2534—40. PMID 7670098.
- Yamaguchi, M.; N, Miki; M, Ono (1995). „Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer.”. Endocrinology. 136 (3): 1072—8. PMID 7867561. doi:10.1210/en.136.3.1072.
- Mehler, M. F.; R, Rozental; M, Dougherty (1993). „Cytokine regulation of neuronal differentiation of hippocampal progenitor cells.”. Nature. 362 (6415): 62—5. PMID 8383296. doi:10.1038/362062a0.
- Morris, J. C.; S, Neben; F, Bennett (1996). „Molecular cloning and characterization of murine interleukin-11.”. Exp. Hematol. 24 (12): 1369—76. PMID 8913282.
- Neddermann P, Graziani R, Ciliberto G, Paonessa G (1997). „Functional expression of soluble human interleukin-11 (IL-11) receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130.”. J. Biol. Chem. 271 (48): 30986—91. PMID 8940087. doi:10.1074/jbc.271.48.30986.
- Barton VA, Hudson KR, Heath JK (1999). „Identification of three distinct receptor binding sites of murine interleukin-11.”. J. Biol. Chem. 274 (9): 5755—61. PMID 10026196. doi:10.1074/jbc.274.9.5755.
- Tacken, I.; H, Dahmen; O, Boisteau (1999). „Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis.”. Eur. J. Biochem. 265 (2): 645—55. PMID 10504396. doi:10.1046/j.1432-1327.1999.00755.x.
- Mahboubi K, Biedermann BC, Carroll JM, Pober JS (2000). „IL-11 activates human endothelial cells to resist immune-mediated injury.”. J. Immunol. 164 (7): 3837—46. PMID 10725745.
- Barton VA, Hall MA, Hudson KR, Heath JK (2000). „Interleukin-11 signals through the formation of a hexameric receptor complex.”. J. Biol. Chem. 275 (46): 36197—203. PMID 10948192. doi:10.1074/jbc.M004648200.
- Curti, A.; A, Tafuri; MR, Ricciardi (2002). „Interleukin-11 induces proliferation of human T-cells and its activity is associated with downregulation of p27(kip1).”. Haematologica. 87 (4): 373—80. PMID 11940481.
- Van der Meeren A; MA, Mouthon; MH, Gaugler (2002). „Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice: interactive effect with thrombopoietin.”. Radiat. Res. 157 (6): 642—9. PMID 12005542. doi:10.1667/0033-7587(2002)157[0642:AORHIA]2.0.CO;2.
- McCloy, M. P.; IA, Roberts; LJ, Howarth (2002). „Interleukin-11 levels in healthy and thrombocytopenic neonates.”. Pediatr. Res. 51 (6): 756—60. PMID 12032273.
- Bartz H, Büning-Pfaue F, Türkel O, Schauer U (2002). „Respiratory syncytial virus induces prostaglandin E2, IL-10 and IL-11 generation in antigen presenting cells.”. Clin. Exp. Immunol. 129 (3): 438—45. PMID 12197884. doi:10.1046/j.1365-2249.2002.01927.x.
Spoljašnje veze[uredi | uredi izvor]
- Interleukin-11 na US National Library of Medicine Medical Subject Headings (MeSH)