CXCL11
| Hemokin (C-X-C motiv) ligand 11 | |||||||||||
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| Dostupne strukture | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | CXCL11; H174; I-TAC; IP-9; IP9; MGC102770; SCYB11; SCYB9B; b-R1 | ||||||||||
| Vanjski ID | OMIM: 604852 MGI: 1860203 HomoloGene: 3944 GeneCards: CXCL11 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Vrsta | Čovek | Miš | |||||||||
| Entrez | 6373 | 56066 | |||||||||
| Ensembl | ENSG00000169248 | n/a | |||||||||
| UniProt | O14625 | n/a | |||||||||
| RefSeq (mRNA) | NM_005409 | NM_019494 | |||||||||
| RefSeq (protein) | NP_005400 | NP_062367 | |||||||||
| Lokacija (UCSC) |
Chr 4: 77.17 - 77.18 Mb | n/a | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
CXCL11, hemokin (C-X-C motiv) ligand 11,[1] je mali citokin i CXC hemokin familije. Om se takođe zove Interferon-inducirani T-ćelijski alfa hemoatraktant (I-TAC) i Interferon-gama-inducirani protein 9 (IP-9). On je visoko izražen u perifernim krvnim leukocitima, pankreasu i jetri, u umerenim nivoima u timus, slezini i plućima, i u niskim nivoima u tankim crevima, posteljici i prostati.[2] Ekspresiju CXCL11 gena je u velikoj meri indukuju IFN-γ i IFN-β, i u maloj meri doprinosi IFN-α.[3] Ovaj hemokin dejstvuje putem interakcija sa hemokin receptorom CXCR3 na površini njegovih ciljnih ćelija, sa većim afinitetom nego drugi ligandi za ovaj receptor, CXCL9 i CXCL10.[2][4] CXCL11 je hemotaksan za aktivirane T ćelije. Njegov gen je lociran na ljudskom hromozomu 4 zajedno sa mnogim drugim članovima CXC hemokin familije.[5][6][7]
Reference[uredi | uredi izvor]
- ^ „Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11”.
- ^ a b Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K (1998). „Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3”. J. Exp. Med. 187 (12): 2009—21. PMC 2212354
. PMID 9625760. doi:10.1084/jem.187.12.2009.
- ^ Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM (1996). „Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha”. J. Biol. Chem. 271 (37): 22878—84. PMID 8798467. doi:10.1074/jbc.271.37.22878.
- ^ Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (1999). „Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)”. J. Invest. Dermatol. 112 (5): 716—22. PMID 10233762. doi:10.1046/j.1523-1747.1999.00581.x.
- ^ Erdel M, Laich A, Utermann G, Werner ER, Werner-Felmayer G (1998). „The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)”. Cytogenet. Cell Genet. 81 (3-4): 271—2. PMID 9730616. doi:10.1159/000015043.
- ^ O'Donovan N, Galvin M, Morgan JG (1999). „Physical mapping of the CXC chemokine locus on human chromosome 4”. Cytogenet. Cell Genet. 84 (1-2): 39—42. PMID 10343098. doi:10.1159/000015209.
- ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
Literatura[uredi | uredi izvor]
- Rani MR; Foster GR; Leung S; et al. (1996). „Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha.”. J. Biol. Chem. 271 (37): 22878—84. PMID 8798467. doi:10.1074/jbc.271.37.22878.
- Jacobs KA; Collins-Racie LA; Colbert M; et al. (1997). „A genetic selection for isolating cDNAs encoding secreted proteins.”. Gene. 198 (1-2): 289—96. PMID 9370294. doi:10.1016/S0378-1119(97)00330-2.
- Cole KE; Strick CA; Paradis TJ; et al. (1998). „Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3.”. J. Exp. Med. 187 (12): 2009—21. PMC 2212354 . PMID 9625760. doi:10.1084/jem.187.12.2009.
- Erdel M; Laich A; Utermann G; et al. (1998). „The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10).”. Cytogenet. Cell Genet. 81 (3-4): 271—2. PMID 9730616. doi:10.1159/000015043.
- Luo Y; Kim R; Gabuzda D; et al. (1999). „The CXC-chemokine, H174: expression in the central nervous system.”. J. Neurovirol. 4 (6): 575—85. PMID 10065899. doi:10.3109/13550289809114224.
- Tensen CP; Flier J; Van Der Raaij-Helmer EM; et al. (1999). „Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).”. J. Invest. Dermatol. 112 (5): 716—22. PMID 10233762. doi:10.1046/j.1523-1747.1999.00581.x.
- Laich A, Meyer M, Werner ER, Werner-Felmayer G (1999). „Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1).”. J. Interferon Cytokine Res. 19 (5): 505—13. PMID 10386863. doi:10.1089/107999099313956.
- Tensen CP; Flier J; Rampersad SS; et al. (1999). „Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene.”. Biochim. Biophys. Acta. 1446 (1-2): 167—72. PMID 10395932.
- Loetscher P; Pellegrino A; Gong JH; et al. (2001). „The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3.”. J. Biol. Chem. 276 (5): 2986—91. PMID 11110785. doi:10.1074/jbc.M005652200.
- Lambeir AM; Proost P; Durinx C; et al. (2001). „Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family.”. J. Biol. Chem. 276 (32): 29839—45. PMID 11390394. doi:10.1074/jbc.M103106200.
- Hensbergen PJ; van der Raaij-Helmer EM; Dijkman R; et al. (2001). „Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity.”. Eur. J. Biochem. 268 (18): 4992—9. PMID 11559369. doi:10.1046/j.0014-2956.2001.02433.x.
- Mohan K, Ding Z, Hanly J, Issekutz TB (2002). „IFN-gamma-inducible T cell alpha chemoattractant is a potent stimulator of normal human blood T lymphocyte transendothelial migration: differential regulation by IFN-gamma and TNF-alpha.”. J. Immunol. 168 (12): 6420—8. PMID 12055261.
- Basu S; Schaefer TM; Ghosh M; et al. (2003). „Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines.”. Cytokine. 18 (3): 140—8. PMID 12126650. doi:10.1006/cyto.2002.0875.
- Salmaggi A; Gelati M; Dufour A; et al. (2003). „Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis.”. J. Interferon Cytokine Res. 22 (6): 631—40. PMID 12162873. doi:10.1089/10799900260100114.
- Rani MR; Hibbert L; Sizemore N; et al. (2002). „Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene.”. J. Biol. Chem. 277 (41): 38456—61. PMID 12169689. doi:10.1074/jbc.M203204200.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Kao J; Kobashigawa J; Fishbein MC; et al. (2003). „Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease.”. Circulation. 107 (15): 1958—61. PMID 12695288. doi:10.1161/01.CIR.0000069270.16498.75.
- Satish L, Yager D, Wells A (2003). „Glu-Leu-Arg-negative CXC chemokine interferon gamma inducible protein-9 as a mediator of epidermal-dermal communication during wound repair.”. J. Invest. Dermatol. 120 (6): 1110—7. PMID 12787142. doi:10.1046/j.1523-1747.2003.12230.x.
- Klunker S; Trautmann A; Akdis M; et al. (2003). „A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis.”. J. Immunol. 171 (2): 1078—84. PMID 12847282.
- Xanthou G, Duchesnes CE, Williams TJ, Pease JE (2003). „CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.”. Eur. J. Immunol. 33 (8): 2241—50. PMID 12884299. doi:10.1002/eji.200323787.
Spoljašnje veze[uredi | uredi izvor]
- Platelet+factor+11 на US National Library of Medicine Medical Subject Headings (MeSH)
