Trombocit faktor 4

Trombocit faktor 4 (hemokin (C-X-C motif) ligand 4)
Trombocit faktor 4 (hemokin (C-X-C motif) ligand 4)
	PDB prikaz baziran na 1f9q.
Dostupne strukture
	1f9q, 1f9r, 1f9s, 1pfm, 1pfn, 1rhp
Identifikatori
Simboli	PF4; CXCL4; MGC138298; SCYB4
Vanjski ID	OMIM: 173460 MGI: 1888711 HomoloGene: 87791 GeneCards: PF4 Gene
Ontologija gena
Molekularna funkcija	• hemokinska aktivnost; • vezivanje heparina;
Celularna komponenta	• ekstracelularni region; • ekstracelularni prostor;
Biološki proces	• imunski odgovor; • negativna regulacija angiogeneze; • citokin i hemokin posredovani signalni put; • aktivacija trombocita; • hemotaksa leukocita; • negativna regulacija diferencijacije megakariocita;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	5196
Ensembl	ENSG00000163737
UniProt	P02776
RefSeq (mRNA)	NM_002619
RefSeq (protein)	NP_002610
Lokacija (UCSC)	Chr 4:; 75.07 - 75.07 Mb
PubMed pretraga	[1]

Trombocit faktor 4 (PF4), ili hemokin (C-X-C motiv) ligand 4 (CXCL4), je mali citokin iz CXC hemokin familije. Ovaj hemokin se oslobađa iz alfa-granula aktiviranih trombocita u toku trombocit agregacije. On promoviše koagulaciju krvi putem dejstva na heparin-slične molekula. Iz tog razloga, za njega je predviđeno da igra ulogu in zarastanju rana i inflamacija.^[1] Njegova glavna fiziološka uloga je neutralizacija heparin-sličnih molekula na endotelnoj površini krvnih sudova, čime se inhibira lokalna antitrombin III aktivnost i promoviše koagulacija.^[2] On se obično nalazi u kompleksu sa proteoglikanom.^[3]

PF4 je izaziva hemotaksu neutrofila, fibroblasta i monocita, i interaguje sa varijantom hemokin receptora CXCR3, poznatom kao CXCR3B.^[4] Gen za ljudski PF4 je lociran na ljudskom hromozomu 4.^[5]

Heparin:PF4 kompleks je antigen u heparin-indukovanoj trombocitopeniji, idiosinkratičnoj autoimunoj reakciji na administraciju antikoagulanta heparina.^[6] PF4 autoantitela su bila nađena kod pacijenata sa trombozom i osobinama poput HIT ali ne pre administracije heparina.^[7]

Vidi još[уреди | уреди извор]

Reference[уреди | уреди извор]

^ Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M (1990). „Structural and functional comparison of the genes for human platelet factor 4 and PF4alt”. Blood. 76 (2): 336—44. PMID 1695112.
^ „Entrez Gene: PF4 platelet factor 4 (chemokine (C-X-C motif) ligand 4)”.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
^ Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, Sagrinati C, Mazzinghi B, Orlando C, Maggi E, Marra F, Romagnani S, Serio M, Romagnani P (2003). „An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4”. J Exp Med. 197 (11): 1537—49. PMC 2193908 . PMID 12782716. doi:10.1084/jem.20021897.
^ O'Donovan N, Galvin M, Morgan J (1999). „Physical mapping of the CXC chemokine locus on human chromosome 4”. Cytogenet Cell Genet. 84 (1-2): 39—42. PMID 10343098. doi:10.1159/000015209.
^ Warkentin TE (2007). „Drug-induced immune-mediated thrombocytopenia--from purpura to thrombosis”. N. Engl. J. Med. 356 (9): 891—3. PMID 17329695. doi:10.1056/NEJMp068309.
^ Warkentin TE, Makris M, Jay RM, Kelton JG (2008). „A spontaneous prothrombotic disorder resembling heparin-induced thrombocytopenia”. Am. J. Med. 121 (7): 632—6. PMID 18589060. doi:10.1016/j.amjmed.2008.03.012.

Literatura[уреди | уреди извор]

Bikfalvi A, Gimenez-Gallego G (2004). „The control of angiogenesis and tumor invasion by platelet factor-4 and platelet factor-4-derived molecules.”. Semin. Thromb. Hemost. 30 (1): 137—44. PMID 15034805. doi:10.1055/s-2004-822978.
Maurer AM, Zhou B, Han ZC (2007). „Roles of platelet factor 4 in hematopoiesis and angiogenesis.”. Growth Factors. 24 (4): 242—52. PMID 17381065. doi:10.1080/08977190600988225.
Deuel TF, Keim PS, Farmer M, Heinrikson RL (1977). „Amino acid sequence of human platelet factor 4.”. Proc. Natl. Acad. Sci. U.S.A. 74 (6): 2256—8. PMC 432148 . PMID 267922. doi:10.1073/pnas.74.6.2256.
Walz DA; Wu VY; de Lamo R; et al. (1978). „Primary structure of human platelet factor 4.”. Thromb. Res. 11 (6): 893—8. PMID 601757. doi:10.1016/0049-3848(77)90117-7.
Nath N, Lowery CT, Niewiarowski S (1975). „Antigenic and antiheparin properties of human platelet factor 4 (PF4).”. Blood. 45 (4): 537—50. PMID 803847.
Hermodson M, Schmer G, Kurachi K (1977). „Isolation, crystallization, and primary amino acid sequence of human platelet factor 4.”. J. Biol. Chem. 252 (18): 6276—9. PMID 893407.
Maione TE; Gray GS; Petro J; et al. (1990). „Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides.”. Science. 247 (4938): 77—9. PMID 1688470. doi:10.1126/science.1688470.
Eisman R; Surrey S; Ramachandran B; et al. (1990). „Structural and functional comparison of the genes for human platelet factor 4 and PF4alt.”. Blood. 76 (2): 336—44. PMID 1695112.
Han ZC, Bellucci S, Tenza D, Caen JP (1990). „Negative regulation of human megakaryocytopoiesis by human platelet factor 4 and beta thromboglobulin: comparative analysis in bone marrow cultures from normal individuals and patients with essential thrombocythaemia and immune thrombocytopenic purpura.”. Br. J. Haematol. 74 (4): 395—401. PMID 2140694. doi:10.1111/j.1365-2141.1990.tb06325.x.
Poncz M; Surrey S; LaRocco P; et al. (1987). „Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line.”. Blood. 69 (1): 219—23. PMID 3098319.
Griffin CA; Emanuel BS; LaRocco P; et al. (1987). „Human platelet factor 4 gene is mapped to 4q12----q21.”. Cytogenet. Cell Genet. 45 (2): 67—9. PMID 3622011. doi:10.1159/000132431.
Senior RM; Griffin GL; Huang JS; et al. (1983). „Chemotactic activity of platelet alpha granule proteins for fibroblasts.”. J. Cell Biol. 96 (2): 382—5. PMC 2112304 . PMID 6187750. doi:10.1083/jcb.96.2.382.
Morgan FJ, Begg GS, Chesterman CN (1980). „Complete covalent structure of human platelet factor 4.”. Thromb. Haemost. 42 (5): 1652—60. PMID 6445090.
Deuel TF; Senior RM; Chang D; et al. (1981). „Platelet factor 4 is chemotactic for neutrophils and monocytes.”. Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4584—7. PMC 319837 . PMID 6945600. doi:10.1073/pnas.78.7.4584.
Brown KJ, Parish CR (1994). „Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor.”. Biochemistry. 33 (46): 13918—27. PMID 7524669. doi:10.1021/bi00250a047.
Mayo KH; Roongta V; Ilyina E; et al. (1995). „NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer.”. Biochemistry. 34 (36): 11399—409. PMID 7547867. doi:10.1021/bi00036a012.
Barker S, Mayo KH (1995). „Quarternary structure amplification of protein folding differences observed in 'native' platelet factor-4.”. FEBS Lett. 357 (3): 301—4. PMID 7835432. doi:10.1016/0014-5793(94)01384-D.
Zhang X; Chen L; Bancroft DP; et al. (1994). „Crystal structure of recombinant human platelet factor 4.”. Biochemistry. 33 (27): 8361—6. PMID 8031770. doi:10.1021/bi00193a025.
Horne MK (1993). „The effect of secreted heparin-binding proteins on heparin binding to platelets.”. Thromb. Res. 70 (1): 91—8. PMID 8511754. doi:10.1016/0049-3848(93)90226-E.
Kolset SO; Mann DM; Uhlin-Hansen L; et al. (1996). „Serglycin-binding proteins in activated macrophages and platelets.”. J. Leukoc. Biol. 59 (4): 545—54. PMID 8613703.

Spoljašnje veze[уреди | уреди извор]

Platelet+factor+4 на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M (1990). „Structural and functional comparison of the genes for human platelet factor 4 and PF4alt”. Blood. 76 (2): 336—44. PMID 1695112.

[2] „Entrez Gene: PF4 platelet factor 4 (chemokine (C-X-C motif) ligand 4)”.

[3] Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[4] Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, Sagrinati C, Mazzinghi B, Orlando C, Maggi E, Marra F, Romagnani S, Serio M, Romagnani P (2003). „An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4”. J Exp Med. 197 (11): 1537—49. PMC 2193908 . PMID 12782716. doi:10.1084/jem.20021897.

[5] O'Donovan N, Galvin M, Morgan J (1999). „Physical mapping of the CXC chemokine locus on human chromosome 4”. Cytogenet Cell Genet. 84 (1-2): 39—42. PMID 10343098. doi:10.1159/000015209.

[6] Warkentin TE (2007). „Drug-induced immune-mediated thrombocytopenia--from purpura to thrombosis”. N. Engl. J. Med. 356 (9): 891—3. PMID 17329695. doi:10.1056/NEJMp068309.

[7] Warkentin TE, Makris M, Jay RM, Kelton JG (2008). „A spontaneous prothrombotic disorder resembling heparin-induced thrombocytopenia”. Am. J. Med. 121 (7): 632—6. PMID 18589060. doi:10.1016/j.amjmed.2008.03.012.

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