TC-1698

TC-1698 je lek koji deluje kao parcijalni agonist na α7 tipu neuronskog nikotinskog acetilholinskog receptora.^[1] On ima neuroprotektivne efekte u žibotinjskim studijama,^[2] i korišten je kao vodeće jedinjenje za razvoj potentnih derivata.^[3]

Reference[уреди | уреди извор]

^ Romanelli, M.; Gratteri, P.; Guandalini, L.; Martini, E.; Bonaccini, C.; Gualtieri, F. (2007). „Central nicotinic receptors: structure, function, ligands, and therapeutic potential”. ChemMedChem. 2 (6): 746—767. PMID 17295372. doi:10.1002/cmdc.200600207.
^ Marrero, M.; Papke, R.; Bhatti, B.; Shaw, S.; Bencherif, M. (2004). „The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo3.2.2nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase”. The Journal of Pharmacology and Experimental Therapeutics. 309 (1): 16—27. PMID 14722323. doi:10.1124/jpet.103.061655.
^ Bhatti, B.; Strachan, J.; Breining, S.; Miller, C.; Tahiri, P.; Crooks, P.; Deo, N.; Day, C.; Caldwell, W. (2008). „Synthesis of 2-(pyridin-3-yl)-1-azabicyclo3.2.2nonane, 2-(pyridin-3-yl)-1-azabicyclo2.2.2octane, and 2-(pyridin-3-yl)-1-azabicyclo3.2.1octane, a class of potent nicotinic acetylcholine receptor-ligands”. The Journal of Organic Chemistry. 73 (9): 3497—3507. PMID 18363376. doi:10.1021/jo800028q.