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Aktivacija centralnih 5--{HT}-<sub>1A</sub> receptora inicira oslobađanje ili inhibiciju [[norepinefrin]]a u zavisnosti od vrste, verovatno iz -{[[locus coeruleus]]}- regiona, što zatim dovodi do redukcije ili povišenja neuronskog tona [[Mišić sfinkter zenice|sfinkter mišića zenice]] modulacijom [[Sinapse|postsinaptičkih]] [[Alfa-2 adrenergički receptor|α<sub>2</sub>-adrenergički receptora]] unutar Edinger-Vestfalnog jezgra, što dovodi do [[Midrijaza|dilatacije zenica]] kod [[glodari|glodara]], i [[mioza|kontrakcije zenica]] kod [[primat]]a uključujući [[čovek|ljude]].<ref name="pmid15087245">{{cite journal | author = Yu Y, Ramage AG, Koss MC. | title = Pharmacological studies of 8-OH-DPAT-induced pupillary dilation in anesthetized rats. | journal = Eur J Pharmacol. | volume = 489 | issue = 3 | pages = 207–213 | year = 2004 | pmid = 15087245 | doi = 10.1016/j.ejphar.2004.03.007 }}</ref><ref name="pmid8982715">{{cite journal | author = Prow MR, Martin KF, Heal DJ | title = 8-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation | journal = Eur J Pharmacol. | volume = 317 | issue = 1 | pages = 21–8 | year = 1996 | pmid = 8982715 | doi = 10.1016/S0014-2999(96)00693-0 }}</ref><ref name="pmid7697953">{{cite journal | author = Fanciullacci M, Sicuteri R, Alessandri M, Geppetti P | title = Buspirone, but not sumatriptan, induces miosis in humans: relevance for a serotoninergic pupil control | journal = Clinical Pharmacology and Therapeutics | volume = 57 | issue = 3 | pages = 349–55 | date=March 1995| pmid = 7697953 | doi = 10.1016/0009-9236(95)90161-2 }}</ref>
Aktivacija centralnih 5--{HT}-<sub>1A</sub> receptora inicira oslobađanje ili inhibiciju [[norepinefrin]]a u zavisnosti od vrste, verovatno iz -{[[locus coeruleus]]}- regiona, što zatim dovodi do redukcije ili povišenja neuronskog tona [[Mišić sfinkter zenice|sfinkter mišića zenice]] modulacijom [[Sinapse|postsinaptičkih]] [[Alfa-2 adrenergički receptor|α<sub>2</sub>-adrenergički receptora]] unutar Edinger-Vestfalnog jezgra, što dovodi do [[Midrijaza|dilatacije zenica]] kod [[glodari|glodara]], i [[mioza|kontrakcije zenica]] kod [[primat]]a uključujući [[čovek|ljude]].<ref name="pmid15087245">{{cite journal | author = Yu Y, Ramage AG, Koss MC. | title = Pharmacological studies of 8-OH-DPAT-induced pupillary dilation in anesthetized rats. | journal = Eur J Pharmacol. | volume = 489 | issue = 3 | pages = 207–213 | year = 2004 | pmid = 15087245 | doi = 10.1016/j.ejphar.2004.03.007 }}</ref><ref name="pmid8982715">{{cite journal | author = Prow MR, Martin KF, Heal DJ | title = 8-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation | journal = Eur J Pharmacol. | volume = 317 | issue = 1 | pages = 21–8 | year = 1996 | pmid = 8982715 | doi = 10.1016/S0014-2999(96)00693-0 }}</ref><ref name="pmid7697953">{{cite journal | author = Fanciullacci M, Sicuteri R, Alessandri M, Geppetti P | title = Buspirone, but not sumatriptan, induces miosis in humans: relevance for a serotoninergic pupil control | journal = Clinical Pharmacology and Therapeutics | volume = 57 | issue = 3 | pages = 349–55 | date=March 1995| pmid = 7697953 | doi = 10.1016/0009-9236(95)90161-2 }}</ref>

Agonisti 5--{HT}-<sub>1A</sub> receptora kao što su [[buspiron]]<ref>{{cite journal |last=Cohn |first=JB |coauthors=Rickels K |year=1989 |title=A pooled, double-blind comparison of the effects of buspirone, diazepam and placebo in women with chronic anxiety |journal=Curr Med Res Opin. |volume=11 |issue=5 |pages=304–320 |pmid=2649317 |doi=10.1185/03007998909115213 |doi_brokendate=2010-01-04 }}</ref> i [[flesinoksan]]<ref name="pmid9169298">{{cite journal | author = Cryan JF, Redmond AM, Kelly JP, Leonard BE. | title = The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat. | journal = Eur Neuropsychopharmacol. | volume = 7 | issue = 2 | pages = 109–114 | year = 1997 | pmid = 9169298 | doi = 10.1016/S0924-977X(96)00391-4 }}</ref> su delotvorni u olakšavanju [[anksioznost|anksioznosti]]<ref name="pmid9724773">{{cite journal | author = Parks CL, Robinson PS, Sibille E, Shenk T, Toth M | title = Increased anxiety of mice lacking the serotonin1A receptor | journal = Proc Natl Acad Sci U S A. | volume = 195 | issue = 18 | pages = 10734–9 | year = 1998 | pmid = 9724773 | doi = 10.1073/pnas.95.18.10734 | pmc = 27964 }}</ref> i [[klinička depresija|depresije]].<ref name="pmid2883013">{{cite journal | author = Kennett GA, Dourish CT, Curzon G | title = Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression | journal = Eur J Pharmacol. | volume = 134 | issue = 3 | pages = 265–74 | year = 1987 | pmid = 2883013 | doi = 10.1016/0014-2999(87)90357-8 }}</ref> [[Buspiron]] i [[tandospiron]] su trenutno odobreni za te indikacije u mnogim zemljama. Drugi, poput [[gepiron]]a,<ref name="pmid15643103">{{cite journal | author = Keller MB, Ruwe FJ, Janssens CJ, Sitsen JM, Jokinen R, Janczewski J | title = Relapse prevention with gepirone ER in outpatients with major depression | journal = Journal of Clinical Psychopharmacology | volume = 25 | issue = 1 | pages = 79–84 | date=February 2005| pmid = 15643103 | doi = 10.1097/01.jcp.0000150221.53877.d9| url = http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0271-0749&volume=25&issue=1&spage=79}}</ref> [[flesinoksan]]a,<ref name="pmid9169298">{{cite journal | author = Cryan JF, Redmond AM, Kelly JP, Leonard BE | title = The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat | journal = European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology | volume = 7 | issue = 2 | pages = 109–14 | date=May 1997| pmid = 9169298 | url = http://linkinghub.elsevier.com/retrieve/pii/S0924-977X(96)00391-4 | doi=10.1016/S0924-977X(96)00391-4}}</ref> [[flibanserin]]a,<ref>{{cite journal|author = Invernizzi RW, Sacchetti G, Parini S, Acconcia S, Samanin R | url=http://www.nature.com/bjp/journal/v139/n7/full/0705341a.html | title= Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors. | journal= Br J Pharmacol.| volume=139| issue=7| pages= 1281–8| date=August 2003| doi= 10.1038/sj.bjp.0705341|pmid = 12890707|pmc = 1573953}}</ref> i -{[[PRX-00023]]}-<ref name="pmid17263189">{{cite journal | author = de Paulis T. | title = Drug evaluation: PRX-00023, a selective 5-HT1A receptor agonist for depression. | journal = Curr Opin Investig Drugs. | volume = 8 | issue = 1 | pages = 78–86 | year = 2007 | pmid = 17263189 }}</ref> su takođe bili ispitivani, mada još uvek nisu potpuno razvijeni i odobreni. Neki od [[atipični antipsihotici|atipičnih antipsihotika]] kao što je [[aripiprazol]]<ref name="pmid17242925">{{cite journal
|author = Stark, AD et al. | title = Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT2A receptors: functional receptor-binding and in vivo electrophysiological studies. | journal = Psychopharmacology (Berl) | volume = 190 | issue = 3 | pages = 373–382 | doi = 10.1007/s00213-006-0621-y | pmid = 17242925 | year = 2007}}</ref> su takođe [[parcijalni agonist]]i 5--{HT}-<sub>1A</sub> receptora i ponekad se koriste u niskim dozama kao zamena za standardne [[antidepresivi|antidepresive]] kao što su [[selektivni inhibitori preuzimanja serotonina]] (SSRI).<ref>{{cite journal|last=Vega|first=JAW|coauthors=Mortimer AM, Tyson PJ|date=May 2003|title=Conventional Antipsychotic Prescription in Unipolar Depression, I: An Audit and Recommendations for Practice |journal=The Journal of Clinical Psychiatry|volume=64|issue=5|pages=568–574|publisher=Physicians Postgraduate Press|issn=1555-2101|url=http://www.psychiatrist.com/abstracts/abstracts.asp?abstract=200305/050311.htm|accessdate=2009-05-28|pmid=12755661|doi=10.4088/JCP.v64n0512}}</ref>


==Literatura==
==Literatura==

Верзија на датум 13. јул 2011. у 17:56

5-hidroksitriptaminski (serotoninski) receptor 1A
Identifikatori
Simboli HTR1A; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1
Vanjski ID OMIM: 109760 MGI: 96273 HomoloGene: 20148 IUPHAR: 5-HT1A GeneCards: HTR1A Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3350 15550
Ensembl ENSG00000178394 ENSMUSG00000021721
UniProt P08908 Q8BGS4
RefSeq (mRNA) NM_000524 NM_008308
RefSeq (protein) NP_000515 NP_032334
Lokacija (UCSC) Chr 5:
63.29 - 63.29 Mb		 Chr 13:
106.56 - 106.57 Mb
PubMed pretraga [1] [2]

5-HT1A receptor je tip 5-HT receptora za koji se vezuje endogeni neurotransmiter serotonin (5-hidroksitriptamin, 5-HT). On je G protein-spregnuti receptor (GPCR) koji je spregnut sa Gi/Go i posreduje inhibitornu neurotransmisiju. Akronim HTR1A označava humani gen koji kodira ovaj receptor.[1][2]

Distribucija

5-HT1A receptor najšire rasprostranjen od svih 5-HT receptora. U centralnom nervnom sistemu, 5-HT1A receptori se nalaze u cerebralnom kortesu, hipokampusu, septumu, amigdali, i rafovom jezgru u visokim koncentracijama, dok su u manjim količinama takođe prisutni u basal ganglia i talamusu.[3][4][5]

Funkcija

Neuromodulacija

5-HT1A receptorski agonisti snižavaju krvni pritisak i brzinu srca centralnim mehanizmom, indukcijom periferne vazodilaticije, i stimulacijom vagus nerva.[6] Ti efekti su rezultat aktivacije 5-HT1A receptora u rostralnoj ventrolateralnoj meduli.[6] Simpatolitički antihipertenzivni lek urapidil je antagonist α1-adrenergičkog receptora i agonist α2-adrenergičkog receptora, kao i agonist 5-HT1A receptora. Poznato je da ova zadnja osobina doprinosi njegovim sveukupnom terapeutskom dejstvu.[7][8] Vazodilatacija krvnih sudova kože centralnom 5-HT1A aktivacijom povećava toplotnu disipaciju sa organizma u okolnu sredinu, posledica čega je sniženje telesne temperature.[9][10]

Aktivacija centralnih 5-HT1A receptora inicira oslobađanje ili inhibiciju norepinefrina u zavisnosti od vrste, verovatno iz locus coeruleus regiona, što zatim dovodi do redukcije ili povišenja neuronskog tona sfinkter mišića zenice modulacijom postsinaptičkih α2-adrenergički receptora unutar Edinger-Vestfalnog jezgra, što dovodi do dilatacije zenica kod glodara, i kontrakcije zenica kod primata uključujući ljude.[11][12][13]

Agonisti 5-HT1A receptora kao što su buspiron[14] i flesinoksan[15] su delotvorni u olakšavanju anksioznosti[16] i depresije.[17] Buspiron i tandospiron su trenutno odobreni za te indikacije u mnogim zemljama. Drugi, poput gepirona,[18] flesinoksana,[15] flibanserina,[19] i PRX-00023[20] su takođe bili ispitivani, mada još uvek nisu potpuno razvijeni i odobreni. Neki od atipičnih antipsihotika kao što je aripiprazol[21] su takođe parcijalni agonisti 5-HT1A receptora i ponekad se koriste u niskim dozama kao zamena za standardne antidepresive kao što su selektivni inhibitori preuzimanja serotonina (SSRI).[22]

Literatura

  1. ^ Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ (новембар 1989). „Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia”. Genomics. 5 (4): 940—4. PMID 2591972. doi:10.1016/0888-7543(89)90138-9. 
  2. ^ „Entrez Gene: HTR1A 5-hydroxytryptamine (serotonin) receptor 1A”. 
  3. ^ Ito H, Halldin C, Farde L. (1999). „Localization of 5-HT1A receptors in the living human brain using [carbonyl-11C]WAY-100635: PET with anatomic standardization technique.”. J Nucl Med. 40 (1): 102—9. PMID 9935065. 
  4. ^ Glennon RA, Dukat M, Westkaemper RB (01. 01. 2000). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Приступљено 11. 04. 2008. 
  5. ^ de Almeida J, Mengod G. (2008). „Serotonin 1A receptors in human and monkey prefrontal cortex are mainly expressed in pyramidal neurons and in a GABAergic interneuron subpopulation: implications for schizophrenia and its treatment.”. J Neurochem. 107 (2): 488—496. PMID 18761712. doi:10.1111/j.1471-4159.2008.05649.x. 
  6. ^ а б Dabiré H. (1991). „Central 5-hydroxytryptamine (5-HT) receptors in blood pressure regulation.”. Therapie. 46 (6): 421—9. PMID 1819150. 
  7. ^ Ramage AG (април 1991). „The mechanism of the sympathoinhibitory action of urapidil: role of 5-HT1A receptors”. Br. J. Pharmacol. 102 (4): 998—1002. PMC 1917978 Слободан приступ. PMID 1855130. 
  8. ^ Kolassa N, Beller KD, Sanders KH. (1989). „Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil.”. Am J Cardiol. 64 (7): 7D—10D. PMID 2569265. doi:10.1016/0002-9149(89)90688-7. 
  9. ^ Ootsuka Y, Blessing WW. (2006). „Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits.”. Brain Res. 1073-1074: 252—61. PMID 16455061. doi:10.1016/j.brainres.2005.12.031. 
  10. ^ Rusyniak DE, Zaretskaia MV, Zaretsky DV, DiMicco JA. (2007). „3,4-Methylenedioxymethamphetamine- and 8-hydroxy-2-di-n-propylamino-tetralin-induced hypothermia: role and location of 5-hydroxytryptamine 1A receptors.”. J Pharmacol Exp Ther. 323 (2): 477—487. PMID 17702902. doi:10.1124/jpet.107.126169. 
  11. ^ Yu Y, Ramage AG, Koss MC. (2004). „Pharmacological studies of 8-OH-DPAT-induced pupillary dilation in anesthetized rats.”. Eur J Pharmacol. 489 (3): 207—213. PMID 15087245. doi:10.1016/j.ejphar.2004.03.007. 
  12. ^ Prow MR, Martin KF, Heal DJ (1996). „8-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation”. Eur J Pharmacol. 317 (1): 21—8. PMID 8982715. doi:10.1016/S0014-2999(96)00693-0. 
  13. ^ Fanciullacci M, Sicuteri R, Alessandri M, Geppetti P (март 1995). „Buspirone, but not sumatriptan, induces miosis in humans: relevance for a serotoninergic pupil control”. Clinical Pharmacology and Therapeutics. 57 (3): 349—55. PMID 7697953. doi:10.1016/0009-9236(95)90161-2. 
  14. ^ Cohn, JB (1989). „A pooled, double-blind comparison of the effects of buspirone, diazepam and placebo in women with chronic anxiety”. Curr Med Res Opin. 11 (5): 304—320. PMID 2649317. doi:10.1185/03007998909115213 (неактивно 2010-01-04).  Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ)
  15. ^ а б Cryan JF, Redmond AM, Kelly JP, Leonard BE. (1997). „The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat.”. Eur Neuropsychopharmacol. 7 (2): 109—114. PMID 9169298. doi:10.1016/S0924-977X(96)00391-4.  Грешка код цитирања: Неисправна ознака <ref>; назив „pmid9169298” је дефинисано више пута с различитим садржајем
  16. ^ Parks CL, Robinson PS, Sibille E, Shenk T, Toth M (1998). „Increased anxiety of mice lacking the serotonin1A receptor”. Proc Natl Acad Sci U S A. 195 (18): 10734—9. PMC 27964 Слободан приступ. PMID 9724773. doi:10.1073/pnas.95.18.10734. 
  17. ^ Kennett GA, Dourish CT, Curzon G (1987). „Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression”. Eur J Pharmacol. 134 (3): 265—74. PMID 2883013. doi:10.1016/0014-2999(87)90357-8. 
  18. ^ Keller MB, Ruwe FJ, Janssens CJ, Sitsen JM, Jokinen R, Janczewski J (фебруар 2005). „Relapse prevention with gepirone ER in outpatients with major depression”. Journal of Clinical Psychopharmacology. 25 (1): 79—84. PMID 15643103. doi:10.1097/01.jcp.0000150221.53877.d9. 
  19. ^ Invernizzi RW, Sacchetti G, Parini S, Acconcia S, Samanin R (август 2003). „Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors.”. Br J Pharmacol. 139 (7): 1281—8. PMC 1573953 Слободан приступ. PMID 12890707. doi:10.1038/sj.bjp.0705341. 
  20. ^ de Paulis T. (2007). „Drug evaluation: PRX-00023, a selective 5-HT1A receptor agonist for depression.”. Curr Opin Investig Drugs. 8 (1): 78—86. PMID 17263189. 
  21. ^ Stark, AD; et al. (2007). „Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT2A receptors: functional receptor-binding and in vivo electrophysiological studies.”. Psychopharmacology (Berl). 190 (3): 373—382. PMID 17242925. doi:10.1007/s00213-006-0621-y. 
  22. ^ Vega, JAW (мај 2003). „Conventional Antipsychotic Prescription in Unipolar Depression, I: An Audit and Recommendations for Practice”. The Journal of Clinical Psychiatry. Physicians Postgraduate Press. 64 (5): 568—574. ISSN 1555-2101. PMID 12755661. doi:10.4088/JCP.v64n0512. Приступљено 2009-05-28.  Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ)

Dodatna literatura

  • el Mestikawy S, Fargin A, Raymond JR; et al. (1991). „The 5-HT1A receptor: an overview of recent advances”. Neurochem. Res. 16 (1): 1—10. PMID 2052135. doi:10.1007/BF00965820. 
  • Hensler JG (2003). „Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration”. Life Sci. 72 (15): 1665—82. PMID 12559389. doi:10.1016/S0024-3205(02)02482-7. 
  • Van Oekelen D, Luyten WH, Leysen JE (2003). „5-HT2A and 5-HT2C receptors and their atypical regulation properties”. Life Sci. 72 (22): 2429—49. PMID 12650852. doi:10.1016/S0024-3205(03)00141-3. 
  • Lesch KP, Gutknecht L (2005). „Focus on The 5-HT1A receptor: emerging role of a gene regulatory variant in psychopathology and pharmacogenetics”. Int. J. Neuropsychopharmacol. 7 (4): 381—5. PMID 15683551. doi:10.1017/S1461145704004845. 
  • Kalipatnapu S, Chattopadhyay A (2006). „Membrane protein solubilization: recent advances and challenges in solubilization of serotonin1A receptors”. IUBMB Life. 57 (7): 505—12. PMID 16081372. doi:10.1080/15216540500167237. 
  • Varrault A, Bockaert J, Waeber C (1992). „Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis”. Mol. Biol. Cell. 3 (9): 961—9. PMC 275657 Слободан приступ. PMID 1330092. 
  • Levy FO, Gudermann T, Perez-Reyes E; et al. (1992). „Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype”. J. Biol. Chem. 267 (11): 7553—62. PMID 1559993. 
  • Melmer G, Sherrington R, Mankoo B; et al. (1992). „A cosmid clone for the 5HT1A receptor (HTR1A) reveals a TaqI RFLP that shows tight linkage to dna loci D5S6, D5S39, and D5S76”. Genomics. 11 (3): 767—9. PMID 1685484. doi:10.1016/0888-7543(91)90088-V. 
  • Parks CL, Chang LS, Shenk T (1992). „A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region”. Nucleic Acids Res. 19 (25): 7155—60. PMC 332551 Слободан приступ. PMID 1766875. doi:10.1093/nar/19.25.7155. 
  • Gilliam TC, Freimer NB, Kaufmann CA; et al. (1990). „Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia”. Genomics. 5 (4): 940—4. PMID 2591972. doi:10.1016/0888-7543(89)90138-9. 
  • Kobilka BK, Frielle T, Collins S; et al. (1987). „An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins”. Nature. 329 (6134): 75—9. PMID 3041227. doi:10.1038/329075a0. 
  • Fargin A, Raymond JR, Lohse MJ; et al. (1988). „The genomic clone G-21, which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor”. Nature. 335 (6188): 358—60. PMID 3138543. doi:10.1038/335358a0. 
  • Nakhai B, Nielsen DA, Linnoila M, Goldman D (1995). „Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28”. Biochem. Biophys. Res. Commun. 210 (2): 530—6. PMID 7755630. doi:10.1006/bbrc.1995.1692. 
  • Aune TM, McGrath KM, Sarr T; et al. (1993). „Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine”. J. Immunol. 151 (3): 1175—83. PMID 8393041. 
  • Parks CL, Shenk T (1996). „The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1”. J. Biol. Chem. 271 (8): 4417—30. PMID 8626793. doi:10.1074/jbc.271.8.4417. 
  • Stockmeier CA, Shapiro LA, Dilley GE; et al. (1998). „Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity”. J. Neurosci. 18 (18): 7394—401. PMID 9736659. 
  • Kawanishi Y, Harada S, Tachikawa H; et al. (1998). „Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia”. Am. J. Med. Genet. 81 (5): 434—9. PMID 9754630. doi:10.1002/(SICI)1096-8628(19980907)81:5<434::AID-AJMG13>3.0.CO;2-D. 
  • Salim K, Fenton T, Bacha J; et al. (2002). „Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation”. J. Biol. Chem. 277 (18): 15482—5. PMID 11854302. doi:10.1074/jbc.M201539200. 

Spoljašnje veze

  • „5-HT1A”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
Преузето из „https://sr.wikipedia.org/w/index.php?title=5-HT1A_receptor&oldid=4548428”