Alfakalcidol

Alfakalcidol
Nazivi
	IUPAC naziv (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Metil-1-[(2R)-6-metilheptan-2-il]-2,3,3a,5,6,7-heksahidro-1H-inden-4-iliden]etiliden]-4-metilidencikloheksae-1,3-diol
	Drugi nazivi 1-Hidroksiholekalciferol
Identifikacija
CAS broj	41294-56-8 ;
3D model (Jmol)	interaktivna slika;
ChemSpider	4445376 ;
DrugBank	DB01436 ;
ECHA InfoCard	100.050.253
KEGG	D01518 ;
PubChem C ID	5282181;
UNII	URQ2517572 ;
	SMILES O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CCCC(C)C)C; ; ; ; ; ;
Svojstva
Hemijska formula	C27H44O2
Molarna masa	400,64 g/mol
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Alfakalcidol (1-hidroksiholelalciferol) je analog vitamina D koji se koristi kao suplement hrane.

Alfakalcidol ima manji uticaj na metabolizam kalcijuma od kalcitriola,^[4] ali je efektivniji u povišavanju nivoa paratiroidnog hormona^[5] i pogledu uticaja na imunski sistem, uključujući regulatorne T ćelije.^[6]^[7]

Reference[uredi | uredi izvor]

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Biological effects of various regimes of 25-hydroxyvitamin D3 (calcidiol) administration on bone mineral metabolism in postmenopausal women, Clin Cases Miner Bone Metab. 2009 May–Aug; 6(2): 169–173
^ Oral calcitriol versus oral alfacalcidol for the treatment of secondary hyperparathyroidism in patients receiving hemodialysis: a randomized, crossover trial Архивирано на сајту Wayback Machine (6. јул 2011), Can J ,Clin Pharmacol Vol 15 (1) Winter 2008:e36 -e43; January 9, 2008
^ Alfacalcidol treatment restores derailed immune-regulation in patients with undifferentiated connective tissue disease, Autoimmunity Reviews, August 2010;
^ of alfacalcidol compared to vitamin D plus calcium in lumbar bone mineral density in postmenopausal osteoporosis, Rheumatol Int. 2006 Mar;26(5):445-53. Epub 2005 Nov 10

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