ABT-670

Из Википедије, слободне енциклопедије
ABT-670
(IUPAC) ime
3-metil-N-(1-oksi-3',4',5',6'-tetrahidro-2'H-[2,4'-bipiridin]-1'-ilmetil)benzamid
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 16094676
ChemSpider[3] 17252978
ChEMBL[4] CHEMBL219182 YesY
Hemijski podaci
Formula C19H23N3O2 
Mol. masa 325,404 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

ABT-670 je lek koji deluje kao potentan, oralno biodostupan dopaminski agonist koji je selektivan za D4 podtip. On je razvijen kao mogući tretman za impotenciju,[5] mada je njegova sadašnja primena ograničena na naučna istraživanja.[6]

Vidi još[уреди]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining“. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ^ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. ^ Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, Nelson SL, Cowart MD, Nakane M (2006). „Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridine-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction“. Journal of medicinal chemistry 49 (25): 7450–65. DOI:10.1021/jm060662k. PMID 17149874. 
  6. ^ Richards N, Wayman C, Allers KA. Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection. Neuroscience Letters. 3 September 2009 doi:10.1016/j.neulet.2009.08.078