Devazepid

Из Википедије, слободне енциклопедије
Devazepid
Devazepide.svg
IUPAC ime
N-(1-methyl- 2-oxo- 5-phenyl- 3H-1,4-benzodiazepin-3-yl)- 1H-indole -2-carboxamide
Identifikatori
CAS broj 103420-77-5 ДаY
ATC kod none
PubChem CID 59751
IUPHAR/BPS 878
KEGG D02693 ДаY
ChEMBL CHEMBL153326 ДаY
Hemijski podaci
Formula C25H20N4O2
Molarna masa 408.452 g/mol
  (verify)

Devazepid (L-364,718, MK-329) je lek koji je strukturni derivat benzodiazepinske familije, ali se po dejstvu veoma razlikuje od većine benzodiazepina. On nema afiniteta za GABAA receptore i umesto toga deluje kao holecistokininski antagonist koji je selektivan za CCKA tip receptora.[1] On povećava apetit i ubrzava želudačano pražnjenje,[2][3] i smatra se da on potencijalno može da služi kao lek za niz gastrointestinalnih problema, među kojima su dispepsija, gastropareza i gastroezofagealna refluksna bolest.[4] On je u širokoj upotrebi u naučnim istraživanjima CCKA receptora.[5][6][7]

Devazepide Scheme.svg

Reference[уреди]

  1. Hill DR, Woodruff GN. Differentiation of central cholecystokinin receptor binding sites using the non-peptide antagonists MK-329 and L-365,260. Brain Research. 1990 Sep 3;526(2):276-83. PMID 2257485
  2. Cooper SJ, Dourish CT. Multiple cholecystokinin (CCK) receptors and CCK-monoamine interactions are instrumental in the control of feeding. Physiology and Behaviour. 1990 Dec;48(6):849-57. PMID 1982361
  3. Cooper SJ, Dourish CT, Clifton PG. CCK antagonists and CCK-monoamine interactions in the control of satiety. American Journal of Clinical Nutrition. 1992 Jan;55(1 Suppl):291S-295S. PMID 1728842
  4. Scarpignato C, Varga G, Corradi C. Effect of CCK and its antagonists on gastric emptying. Journal of Physiology Paris. 1993;87(5):291-300. PMID 8298606
  5. Weller A. The ontogeny of postingestive inhibitory stimuli: examining the role of CCK. Developmental Psychobiology. 2006 Jul;48(5):368-79. PMID 16770766
  6. Savastano DM, Covasa M. Intestinal nutrients elicit satiation through concomitant activation of CCK(1) and 5-HT(3) receptors. Physiology and Behaviour. 2007 Oct 22;92(3):434-42. PMID 17531277
  7. Evans, B. E.; Rittle, K. E.; DiPardo, R. M.; Freidinger, R. M.; Whitter,W. L.; People,W. T.; Lendell, G. F.; Veber, D. F.; Anderson, P. S.; Chang, R. S. L.; Lotti, V. J.; Cerino, D. J.; Chen, T. B.; Kling, P. J.; Kunkel, K. A.; Springer, J. P.; Hirschfield, J. (1988). J. Med. Chem. 31: 2235 http://dx.doi.org/10.1021/jm00120a002. 

Spoljašnje veze[уреди]