Devazepid
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| IUPAC ime | |
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N-(1-methyl- 2-oxo- 5-phenyl- 3H-1,4-benzodiazepin-3-yl)- 1H-indole -2-carboxamide
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| Identifikatori | |
| CAS broj | 103420-77-5  |
| ATC kod | none |
| PubChem | CID 59751 |
| IUPHAR/BPS | 878 |
| KEGG | D02693 |
| ChEMBL | CHEMBL153326 |
| Hemijski podaci | |
| Formula | C25H20N4O2 |
| Molarna masa | 408.452 g/mol |
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Devazepid (L-364,718, MK-329) je lek koji je strukturni derivat benzodiazepinske familije, ali se po dejstvu veoma razlikuje od većine benzodiazepina. On nema afiniteta za GABAA receptore i umesto toga deluje kao holecistokininski antagonist koji je selektivan za CCKA tip receptora.[1] On povećava apetit i ubrzava želudačano pražnjenje,[2][3] i smatra se da on potencijalno može da služi kao lek za niz gastrointestinalnih problema, među kojima su dispepsija, gastropareza i gastroezofagealna refluksna bolest.[4] On je u širokoj upotrebi u naučnim istraživanjima CCKA receptora.[5][6][7]
Reference[уреди]
- ^ Hill DR, Woodruff GN. Differentiation of central cholecystokinin receptor binding sites using the non-peptide antagonists MK-329 and L-365,260. Brain Research. 1990 Sep 3;526(2):276-83. PMID 2257485
- ^ Cooper SJ, Dourish CT. Multiple cholecystokinin (CCK) receptors and CCK-monoamine interactions are instrumental in the control of feeding. Physiology and Behaviour. 1990 Dec;48(6):849-57. PMID 1982361
- ^ Cooper SJ, Dourish CT, Clifton PG. CCK antagonists and CCK-monoamine interactions in the control of satiety. American Journal of Clinical Nutrition. 1992 Jan;55(1 Suppl):291S-295S. PMID 1728842
- ^ Scarpignato C, Varga G, Corradi C. Effect of CCK and its antagonists on gastric emptying. Journal of Physiology Paris. 1993;87(5):291-300. PMID 8298606
- ^ Weller A. The ontogeny of postingestive inhibitory stimuli: examining the role of CCK. Developmental Psychobiology. 2006 Jul;48(5):368-79. PMID 16770766
- ^ Savastano DM, Covasa M. Intestinal nutrients elicit satiation through concomitant activation of CCK(1) and 5-HT(3) receptors. Physiology and Behaviour. 2007 Oct 22;92(3):434-42. PMID 17531277
- ^ Evans, B. E.; Rittle, K. E.; DiPardo, R. M.; Freidinger, R. M.; Whitter,W. L.; People,W. T.; Lendell, G. F.; Veber, D. F.; Anderson, P. S.; Chang, R. S. L.; Lotti, V. J.; Cerino, D. J.; Chen, T. B.; Kling, P. J.; Kunkel, K. A.; Springer, J. P.; Hirschfield, J. (1988). J. Med. Chem. 31: 2235 http://dx.doi.org/10.1021/jm00120a002. Недостаје или је празан параметар
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