SNAP-94847

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SNAP-94847
SNAP-94847 structure.png
IUPAC ime
N-(3-[1-([4-(3,4-difluorofenoksi)fenil]metil)(4-piperidil)]-4-metilfenil)-2-metilpropanamid
Identifikatori
ATC kod none
Hemijski podaci
Formula C29H32F2N2O2
Molarna masa 478,572
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SNAP-94847 je lek koji se koristi u naučnim istraživanjima. On je selektivni nepeptidni antagonist melanin-koncentrirajućeg hormonskog receptora MCH1. U životinjskim studijama je pokazano da proizvodi anksiolitičke i antidepresivne efekte.[1][2] On isto tako redukuje unos hrane, tako da on potencijalno ima i anoreksno dejstvo.[3]

Reference[уреди]

  1. {{cite journal |vauthors=David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R |title=Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=321 |issue=1 |pages=237–48 |year=2007 |pmid=17237257 |doi=10.1124/jpet.106.109678 |url=}}
  2. Smith DG, Hegde LG, Wolinsky TD, Miller S, Papp M, Ping X, Edwards T, Gerald CP, Craig DA (2009). „The effects of stressful stimuli and hypothalamic-pituitary-adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP 94847 in rodents”. Behavioural Brain Research. 197 (2): 284—91. PMID 18793675. doi:10.1016/j.bbr.2008.08.026. 
  3. Nair SG, Adams-Deutsch T, Pickens CL, Smith DG, Shaham Y (2009). „Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats”. Psychopharmacology. 205 (1): 129—40. PMID 19340414. doi:10.1007/s00213-009-1523-6. 

Spoljašnje veze[уреди]

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