Neuropeptidni Y receptor Y2
| Neuropeptidni Y receptor Y2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | NPY2R; | ||||||||||
| Vanjski ID | OMIM: 162642 MGI: 108418 HomoloGene: 701 IUPHAR: Y2 GeneCards: NPY2R Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4887 | 18167 | |||||||||
| Ensembl | ENSG00000185149 | ENSMUSG00000028004 | |||||||||
| UniProt | P49146 | Q8BWV1 | |||||||||
| RefSeq (mRNA) | NM_000910 | NM_008731 | |||||||||
| RefSeq (protein) | NP_000901 | NP_032757 | |||||||||
| Lokacija (UCSC) |
Chr 4: 156.35 - 156.36 Mb |
Chr 3: 82.62 - 82.63 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Neuropeptidni Y receptor tip 2 je protein koji je kod ljudi kodiran NPY2R genom.[1][2]
Selektivni ligandi[уреди | уреди извор]
Agonisti[уреди | уреди извор]
- Neuropeptid Y (endogeni agonist, nije podtip selektivan)
- Neuropeptidni Y fragment 13-36 (NPY2 selektivni agonist)
- 2-Tiouridin 5'-trifosfat
- Peptid YY
- Peptid YY 3-36 fragment[3]
Antagonisti[уреди | уреди извор]
Vidi još[уреди | уреди извор]
Literatura[уреди | уреди извор]
- ^ Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (1995). „Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor”. J Biol Chem. 270 (39): 22661—4. PMID 7559383. doi:10.1074/jbc.270.39.22661.
- ^ „Entrez Gene: NPY2R neuropeptide Y receptor Y2”.
- ^ Murphy KG, Dhillo WS, Bloom SR (2006). „Gut peptides in the regulation of food intake and energy homeostasis”. Endocrine Reviews. 27 (7): 719—27. PMID 17077190. doi:10.1210/er.2006-0028.
Dodatna literatura[уреди | уреди извор]
- Wan CP, Lau BH (1997). „Neuropeptide Y receptor subtypes.”. Life Sci. 56 (13): 1055—64. PMID 9001438. doi:10.1016/0024-3205(95)00041-4.
- Parker E, Van Heek M, Stamford A (2002). „Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.”. Eur. J. Pharmacol. 440 (2-3): 173—87. PMID 12007534. doi:10.1016/S0014-2999(02)01427-9.
- Herzog H; Hort YJ; Ball HJ; et al. (1992). „Cloned human neuropeptide Y receptor couples to two different second messenger systems.”. Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5794—8. PMC 402104
. PMID 1321422. doi:10.1073/pnas.89.13.5794. - Gerald C; Walker MW; Vaysse PJ; et al. (1995). „Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.”. J. Biol. Chem. 270 (45): 26758—61. PMID 7592910. doi:10.1074/jbc.270.45.26758.
- Lynch JW; Lemos VS; Bucher B; et al. (1994). „A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line.”. J. Biol. Chem. 269 (11): 8226—33. PMID 8132547.
- Gehlert DR; Beavers LS; Johnson D; et al. (1996). „Expression cloning of a human brain neuropeptide Y Y2 receptor.”. Mol. Pharmacol. 49 (2): 224—8. PMID 8632753.
- Yan H; Yang J; Marasco J; et al. (1996). „Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.”. Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4661—5. PMC 39335 . PMID 8643460. doi:10.1073/pnas.93.10.4661.
- Ammar DA; Eadie DM; Wong DJ; et al. (1997). „Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene.”. Genomics. 38 (3): 392—8. PMID 8975716. doi:10.1006/geno.1996.0642.
- Snow BE; Hall RA; Krumins AM; et al. (1998). „GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.”. J. Biol. Chem. 273 (28): 17749—55. PMID 9651375. doi:10.1074/jbc.273.28.17749.
- Caberlotto L; Fuxe K; Rimland JM; et al. (1998). „Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain.”. Neuroscience. 86 (1): 167—78. PMID 9692752. doi:10.1016/S0306-4522(98)00039-6.
- Goumain M; Voisin T; Lorinet AM; et al. (2001). „The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning.”. Mol. Pharmacol. 60 (1): 124—34. PMID 11408607.
- Cox HM, Tough IR (2002). „Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.”. Br. J. Pharmacol. 135 (6): 1505—12. PMC 1573267 . PMID 11906964. doi:10.1038/sj.bjp.0704604.
- Uddman R; Möller S; Nilsson T; et al. (2003). „Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues.”. Peptides. 23 (5): 927—34. PMID 12084524. doi:10.1016/S0196-9781(02)00003-7.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Hyland NP; Sjöberg F; Tough IR; et al. (2004). „Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues.”. Br. J. Pharmacol. 139 (4): 863—71. PMC 1573894 . PMID 12813010. doi:10.1038/sj.bjp.0705298.
- Hung CC; Pirie F; Luan J; et al. (2004). „Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.”. Diabetes. 53 (9): 2461—6. PMID 15331560. doi:10.2337/diabetes.53.9.2461.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Spoljašnje veze[уреди | уреди извор]
- „Neuropeptide Y Receptors: Y2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.