Melanokortinski 3 receptor

Из Википедије, слободне енциклопедије
Melanokortin 3 receptor
Identifikatori
Simboli MC3R; MC3
Vanjski ID OMIM155540 MGI96929 HomoloGene7412 IUPHAR: MC3 GeneCards: MC3R Gene
Pregled RNK izražavanja
PBB GE MC3R 221442 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 4159 17201
Ensembl ENSG00000124089 ENSMUSG00000038537
UniProt P41968 Q3ZAT4
RefSeq (mRNA) NM_019888 NM_008561
RefSeq (protein) NP_063941 NP_032587
Lokacija (UCSC) Chr 20:
54.26 - 54.26 Mb
Chr 2:
171.94 - 171.94 Mb
PubMed pretraga [1] [2]

Melanokortin receptor 3 je protein koji je kod ljudi kodiran MC3R genom.[1][2]


MC3 je G-protein spregnuti receptor za melanocit-stimulišući hormon i adrenokortikotropski hormon koji je izražen u tkivima izvan adrenalnog korteksa i melanocita. MC3R gen je lociran u istom regionu kao i locus za benignu neonatalnu epilepsiju. Miševi koji su deficitarni u ovom genu imaju povišenu masu masnog tkiva uprkos umanjenog unosa hrane, što sugestira ulogu ovog genskog produkta u regulaciji energijske homeostaze.[2]

Vidi još[уреди]

Literatura[уреди]

  1. Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T (1993). „Molecular cloning of a novel melanocortin receptor”. J Biol Chem 268 (11): 8246—50. PMID 8463333. 
  2. 2,0 2,1 „Entrez Gene: MC3R melanocortin 3 receptor”. 

Dodatna literatura[уреди]

  • Magenis RE, Smith L, Nadeau JH; et al. (1994). „Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human.”. Mamm. Genome 5 (8): 503—8. doi:10.1007/BF00369320. PMID 7949735. 
  • Konda Y, Gantz I, DelValle J; et al. (1994). „Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor.”. J. Biol. Chem. 269 (18): 13162—6. PMID 8175743. 
  • Gantz I, Tashiro T, Barcroft C; et al. (1994). „Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization.”. Genomics 18 (1): 166—7. doi:10.1006/geno.1993.1448. PMID 8276410. 
  • Yang YK, Ollmann MM, Wilson BD; et al. (1997). „Effects of recombinant agouti-signaling protein on melanocortin action.”. Mol. Endocrinol. 11 (3): 274—80. doi:10.1210/me.11.3.274. PMID 9058374. 
  • Tota MR, Smith TS, Mao C; et al. (1999). „Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors.”. Biochemistry 38 (3): 897—904. doi:10.1021/bi9815602. PMID 9893984. 
  • McNulty JC, Thompson DA, Bolin KA; et al. (2002). „High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein.”. Biochemistry 40 (51): 15520—7. doi:10.1021/bi0117192. PMID 11747427. 
  • Deloukas P, Matthews LH, Ashurst J; et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature 414 (6866): 865—71. doi:10.1038/414865a. PMID 11780052. 
  • Lee YS, Poh LK, Loke KY (2002). „A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity.”. J. Clin. Endocrinol. Metab. 87 (3): 1423—6. doi:10.1210/jc.87.3.1423. PMID 11889220. 
  • Qian S, Chen H, Weingarth D; et al. (2002). „Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice.”. Mol. Cell. Biol. 22 (14): 5027—35. doi:10.1128/MCB.22.14.5027-5035.2002. PMC 139785. PMID 12077332. 
  • Boucher N, Lanouette CM, Larose M; et al. (2003). „A +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence.”. Mol. Med. 8 (3): 158—65. PMC 2039979. PMID 12142547. 
  • Wong J, Love DR, Kyle C; et al. (2002). „Melanocortin-3 receptor gene variants in a Maori kindred with obesity and early onset type 2 diabetes.”. Diabetes Res. Clin. Pract. 58 (1): 61—71. doi:10.1016/S0168-8227(02)00126-2. PMID 12161058. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Rached M, Buronfosse A, Begeot M, Penhoat A (2004). „Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity.”. Biochim. Biophys. Acta 1689 (3): 229—34. doi:10.1016/j.bbadis.2004.03.009. PMID 15276649. 
  • Tao YX, Segaloff DL (2004). „Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.”. J. Clin. Endocrinol. Metab. 89 (8): 3936—42. doi:10.1210/jc.2004-0367. PMID 15292330. 
  • Lapinsh M, Veiksina S, Uhlén S; et al. (2005). „Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.”. Mol. Pharmacol. 67 (1): 50—9. doi:10.1124/mol.104.002857. PMID 15470082. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Mandrika I, Petrovska R, Wikberg J (2005). „Melanocortin receptors form constitutive homo- and heterodimers.”. Biochem. Biophys. Res. Commun. 326 (2): 349—54. doi:10.1016/j.bbrc.2004.11.036. PMID 15582585. 
  • de Krom M, de Rijke CE, Hendriks J; et al. (2006). „Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients.”. Psychiatr. Genet. 15 (4): 237. doi:10.1097/00041444-200512000-00003. PMID 16314751. 
  • Chen M, Aprahamian CJ, Celik A; et al. (2006). „Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction.”. Biochemistry 45 (4): 1128—37. doi:10.1021/bi0521792. PMID 16430209. 
  • „Melanocortin Receptors: MC3. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.